3M General Offices 3M Center St.

ATTACHMENT TO LETTER OF 1/18/05 3M FLUOROCHEMICAL SUBMISSION AZ2r no I 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Multiple Chemicals o "Inter-Species Comparison of Mechanisms Fluorochemical Toxicity following Intraperitoneal dosing of perfluorooctanesulfonate (PFOS, T-6295) or ammonium perfluorooctanoate (APFO, T-6889) in Rats and Guinea Pigs and oral dosing of N-ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316) in Rats," 3M Medical Department Corporate Toxicology, DT15-A, May 24, 2004. 2.

AR226-2199 Chris E Shoop 09/05/2001 11:16 AM To: Debbie J Mulrooney/AE/DuPont@DuPont ' cc: Stephen J Gissy/AE/DuPont@DuPont, Robert L Ritchey/CL/DuPont@DuPont, Robert F Pinchot/DEV/AE/DuPont@DuPont, M.

AR226-2519 Ta-Wei Fu /I 11/12/02 02:13 PM To: Charles J Noelke/AE/DuPont@DuPont cc: Steven H Swearingen/AE/DuPont@DuPont Subject: Eureka!

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AR226-2713 AR226-2713 UDR-TR-2004-00025 FINAL REPORT Laboratory-Scale Thermal Degradation of Fluorocarbon Materials July 2004 Final Report - July 6,2004 Laboratory-Scale Thermal Degradation of Fluorocarbon Materials Takahiro Yamada, Ph.D.

AR226-2867 Copies E.

AR226-2997 STUDY TITLE: CHROMOSOME ABERRATION ASSAY IN CHINESE HAMSTER V79 CELLS IN VITRO WITH REPORT DATA REQUIREMENTS: OECD Guideline 473 EEC Directive 92/69 EPA 40 CFR Ch. 1 (7-1-86 ed. 798.5385) AUTHOR: Dr.

AR226-3052 DuPont HLR &40-96 Local Lymph Node Assay Screen with H21951 The Local Lymph Node Assay (LLNA) screen with H219S1 was conducted in female CBA/JHsd mice.

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AR226-3385 Subchronic, Developmental, and Reproductive Toxicity o f a Fluoroalkylethyl Phosphate Surfactant J.C.

RECYCLED P'S m I v > C-8 T ' - AMMONIUM PEUFLUOROOCTANOATE CHRONOLOGICAL SUMMARY OF REPORTS Month/Year Sources June 1978 3M Co. discussion BVU UA Peonie 130 nu . ui Samples ?

R&el ,,2106 000380 C-8 BLOOD LEVELS IN FEMALES TRANSFERRED OUT OF TEFLON C-8 LEVEL WHEN AGE LEAVING TEFLON 32 0.140 27 0.192 27 0.570 33 1.300 24 0.110 27 0.110 27 0,078 37 2.400 27 5.100 23 0.061 29 0.270 31 0.190 26 0.045 32 * 0.450 27 0,230 25 0.092 33 0,019 28 2.500 C-8 LEVEL AFTER LEAVING TEFLON 0.086 0.120 0.390 0.980 0.086 0.091 0.065 2.000 4,400 0.053 0.240 0.170 0.041 0.410 0.210 0,092 0.019 2.600 NUMBER OF DAYS BETWEEN SAMPLES 143 127 140 126 128 133 148 139 126 128 130 127 96 127 127 126 133 126 % CHANGE IN C-8 BLOOD LEVELS -38.6 -37.5 -31.6 -24.6 -21.8 -17.3 -16.7 -16.7 -13,7 -13.1 -11,1 -10.5 - 8,9 - 8,9 - 8.7 0.0 0.0 + 4.0 AVERAGE = 129 days -15.3 + 11.7* * The downward trend is statistically significant at 0.05 level using the paired-t test. 12/1/81 0337W 000381

AH&&.6- $6(K A preliminary list of published references being considered in the update to the science Prepared following the completion of the environmental and human health risk assessments of the 4 notified polymers.

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