Document eg6GOzMD1mqYEw6EjbgVbDmy

WASHINGTON WORKS Teflon Polymer Division PERSONAL AND CONFIDENTIAL OTO: W. T. DARNELL T. M. KEMP FROM: R. J. Z I P F E L ^ / ^ CC: J. G. Loschi avo P. Thistleton October 7, 1982 cd(O^c. Jo O lA u a J l* * * - c-8 AecV^ kuouJ . xsv\ o-co* s iiji *JLtsO C -8 ELIMINATION RATES t* c u a . ^A o"t" juo&vjlj C-8 blood data received to date is not adequately defining the long term equilibrium C-8 blood level in our employees, or the elimination rate in employees no longer exposed to C-8. One of the objectives of our present C-8 program is to determine the correlation of C-8 blood levels to personal C-8 exposure levels. These data are critical if we are to determine the future normal C-8 blood levels that our employees will have. (Note: Based on present information C-8 blood levels will always be above the detectable point in the future.) At some later point we will tflu * need to mak ---- ei-- a9 firm assessment as to the safety of this ~~ normal level. " A key point in this study is the determination of human C-8 elimination rates for both males and females. Presently, we are only obtaining these data from the females who left TEFLON in April, 1981. No such data exists for males, who are the employees with the highest C-8 blood levels. According to Haskell Lab the only way to get statistically accurate data is to monitor personnel who are no longer exposed to C-8. It has been proposed by Plant ER and SHE personnel that data presently being collected from the TEFLON males is adequate for this purpose. We feel that due to the complication factors of daily exposure variability and an extremely long half-life (> 12 months) that the determination of the elimination rate from these data could take an additional 5 years. The elimination rate determined via these data will always be questionable as to accuracy. The only way we know, and Haskell Lab concurs, to determine a statistically accurate elimination rate (or half-life) for C-8 is to monitor males who have high C-8 levels and have left TEFLON. This means the monitoring of TEFLON retirees. We believe this point to be very important and critical in our C-8 program. I will be glad to discuss this further with you. AJP001233 RJZ/n sw 1078W 000227 EID080633