Document R93VqLz4MDnbJwnxZLxyyLVB

AF.aa.6 _ 1363 O P r im e d ic a Argus Division | 9 0 5 Sheehy Drive, Bldg. A ' Horsham, PA 19044 Tel 2 1 5 . 4 4 3 . 8 7 1 0 ] Fox 21 5 . 4 4 3 . 8 5 8 7 Irh Y OCT 1 3 2000 IMI GSD O IMI fcj October 12, 2000 Marvin T. Case, D.V.M., Ph.D. 3M Toxicology Services 3M Center, Building 220-2E-02 St. Paul, Minnesota 55144-1000 Telephone: (651)733-5180 Telefax: (651)733-1773 RE: Protocol 418-009 - Combined Oral(Gavage) Fertility, Developmental and Perinatal/Postnatal Reproduction Toxicity Study of N-EtFOSE in Rats Dear Dr. Case: Enclosed is a copy of the issued final Report Amendment 1 to the above-referenced protocol. If you have any questions, please do not hesitate to contact me. Sincerely, RGY:rg Enc. Associate Director of Research and Study Director 001711 Primedico C orporation j www.prim edica. Primedica Argus Research Laboratories, Inc 905 Sheehy Drive, Building A Horsham, PA 19044 Telephone: (215) 443-8710 Telefax: (215)443-8587 REPORT AMENDMENT 1 12 OCTOBER 2000 PROTOCOL 418-009 COMBINED ORAL (GAVAGE) FERTILITY, DEVELOPMENTAL AND PERINATAL/POSTNATAL REPRODUCTION TOXICITY STUDY OF N-ETFOSE IN RATS FINAL REPORT Attached is the corrected Text Figure 1 to the above-referenced final report. This change reflects the addition of a notation for the dosage administration of the FI generation rats and did not affect the results of the study. Associate Director of Research and Study Director `O CT-Co Date oa-oo fi. Nancy J. Gongliewski Date [ y Manager of Regulatory Compliance 001712 PROTOCOL 411-009: COMBINED ORAL (GAVAGE) FERTILITY, DEVELOPMENTAL AND PERINATAL/POSTNATAL REPRODUCTION TOXICITY STUDY OF N-EIFOSE IN RATS cc K Cc 418-OOy:PAUt i-H REVISED PAGE