ARm-om Compound-Specific, Quantitative Characterization of Organic Fluorochemicals in Biological Matrices Kristen J.

^ 226- 02/6 Attachments to Letter to C.

Corporate Toxicology Study Outline July, 1998 MlX-oi n DT22; T-7121.1 FC-129 Title: FC-129 Preliminary ADME Screen in Rats Timeline: In Life Start Date: 7/13/98 In Life End Date: 7/17/98 Purpose: This study is designed to provide preliminary information on the absorption, distribution, metabolism and excretion (ADME) of FC-129.

FINAL MULTI-CITY STUDY FIELD REPORT FOR MOBILE ALABAMA AND PENSACOLA FLORIDA - BATTELLE DUXBURY ACTIVITIES for .

PFOS: A 96-HOUR TOXICITY TEST WITH THE MARINE DIATOM (Skeletonema costatum) FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

PFOS: A 96-HOUR TOXICITY TEST WITH THE FRESHWATER ALGA (Anabaenaflos-aquae) FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

BACK TO MAIN WATER SOLUBILITY IN PURE WATER- SHAKE FLASK METHOD TEST SUBSTANCE________________________________ Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder.

BACK TO MAIN SOLUBILITY IN OCTANOL- SHAKE FLASK METHOD TEST SUBSTANCE______________________ Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder.

/IR 21G -0093 PFOS: AN ACTIVATED SLUDGE, RESPIRATION INHIBITION TEST FINAL REPORT WILDLIFE INTERNATIONAL LTD.

A R 1 2 C - 0 1 ^Attachments to Letter to C.

Experim ent No.: Conducted At: D ates Conducted: Conducted By: Reviewed By: Primary Skin I r r it a t io n T e st w ith T-3421 in A lbino R abbits 0883EB0288 ARUfe-OatZ V % Safety Evaluation Laboratory Riker L ab o rato ries, Inc.

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3M Environmental Laboratory R126-0005 M ethod A nalysis of Potassium Perfluorooctanesulfonate or O ther Fluorochemicals in Serum Extracts U sing H PLC-Electrospray/M ass Spectrometry Method Number: ETS-8-5.1 Author: Lisa Clemen, Robert Wynne Approved By: 'L l Laboratory Manager Adoption Date: 03/01/99 Revision Date: <V / 2 C / Date Group Leader Technical Reviewer Date dh i / m Date 1.0 S c o p e a n d A p p l ic a t io n __________________________________________________________________ 1.1 Scope: This method describes the analysis of serum extracts for fluorochemical surfactants using HPLC-electrospray/mass spectrometry. 1.2 Applicable Compounds: Fluorochemical surfactants or other fluorinated compounds, or other ionizable compounds. 1.3 Matrices: Rabbit, rat, bovine, monkey, and human serum, or other fluids as designated in the validation report.

FINAL REPORT ^ R X L6-055*J RECEIVED QPPT CBiC 2000FEB 22 AHIh3L PROTOCOL 418-008 COMBINED ORAL (GAVAGE) FERTILITY, DEVELOPMENTAL AND PERINATAL/POSTNATAL REPRODUCTION TOXICITY STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: 6295.9 FINAL REPORT DATE: 10 JUNE 1999 000502 PROTOCOL 418-008 COMBINED ORAL (GAVAGE) FERTILITY, DEVELOPMENTAL AND PERINATAL/POSTNATAL REPRODUCTION TOXICITY STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: 6295.9 TABLE OF CONTENTS SUBJECT I.

t\^r&-05Vt, FINAL REPORT PROTOCOL 418-015 ORAL (GAVAGE) PHARMACOKINETIC RECOVERY STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: T-6295.14 FINAL REPORT DATE: 23 JULY 1999 001001 PROTOCOL 418-015 ORAL (GAVAGE) PHARMACOKINETIC RECOVERY STUDY OF PFOS IN RATS SPONSOR'S STUDY NUMBER: T-6295.14 TABLE OF CONTENTS SUBJECT PAGE I.