Document k6gjo7XX0qn2ovG4BopKnZ94J

M&SL - 14-99 Review o f APME-Sponsored Kinetics I. A D E - Reported 1Q/2003 II. Proteiji - Binding - 3 manuscripts 3Q/2003 &* III. M odeling - Rat - derived compartment model Hum an model considerations 3Q/2003 7/25/03 GL Kennedy *1*1**8 HIT *?- d3S002 Project: Inhalation Kinetics - Rat Purpose: To relate inhalation exposure to an APFO blood level (for comparison to oral data) General Design: 3 exposure concentrations (1,10,25 mg/m3) 3 weeks of exposure (6 hr/d x 5d/wk) Both sexes Sample immediately before and after exposure daily (used pilot study to determine timing of blood levels) Date Available: August, 2003 i Report Available: October, 2003 7/25/03 GL Kennedy Project: Lactational Transport Kinetics - Rat Purpose: To determine transfer of PFO to offspring from lactating dam (in a quantitative manner) General Design: Oral doses o f 3 ,1 0 .3 0 mg/kg G D 4 - L D 4 , 7, 14, 21 (follow same rats) Collecting maternal blood, milk and offspring blood Analyze for PFOA Data Available: October, 2003 Report Available: December, 2003 7/25/03 GL Kennedy Project: Placental Transport Kinetics - Rat Purpose: To determine transfer of APFO from mother to fetus (in a quantitative maimer) General Design: Oral doses of 3,10,30 mg/kg GD 4- 10; 4-15; 4-21 Collect maternal blood and conceptus/ fetal "blood" (amniotic fluid, placenta in later gestation) Analyze for PFOA Data Available: October, 2003 Report Available: December, 2003 7/25/03 GL Kennedy Project: Effect o f Age of PFOA-Elimination - Rat Purpose: To determine at what age differential excretion o f APFO occurs in male and female rats General Design: Single oral doses (10 mg/kg) Dosed rats at 4 wk, 5 wk, 6 wk, 7 wk, 8 wks of age (separate groups) Blood APFO determined 24 hrs post-dose Data Available: September, 2003 Report Analysis: December, 2003 7/25/03 GL Kennedy S