Report E01-1245 PFOS: A Reproduction Study with the Nothern Bobwhite Study Title A nalytical Phase Report for PFOS: A Reproduction Study with T he Northern Bobwhite Data Requirement FIFRA Subdivision E, Section 71-4 OECD Guideline 206 Author Lisa A.

NOTICE: The information provided to the agency contains information that 3M voluntarily has submitted as part of our continuing discussions with the EPA regarding fluorochemistry.

BACK TO MAIN 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE May 2000 Click on Study Title to View Report May 2, 2000 Cell Proliferation Study: In-Life Appendix, "Cell Proliferation Study with N-Ethyl Perfluorooctanesulfona mido Ethanol (N-EtFOSE; 3M T-6316.11), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS; 3M T-6295.16), and N-Ethyl Perfluorooctansulfonamide (PFOSA; 3M T-7091.1) in Rats," TherImmune Research Corporation, TRC 1132-100, May 2, 000 (Appendix 1 to full report).

mm-onaBESTCOPY AVAIlABLE Ji:i 1lillSON Ml OK ' : o n i . m o u vs j i : 11tn; l R E C E IV E D Daniel Baugh Institute of Anatomy Department o f Anatomy Offiee o f the Director and Chairman mC5& ..

STUDY TITLE Extraction o f Potassium Perfluorooctanesulfonate from Quail Serum and Quail Liver for Analysis Using HPLC-Electrospray/Mass Spectrometry DATA REQUIREM ENTS Analytical Method Requirements STUDY DIRECTO R Sean Gallagher STUDY COM PLETED ON September 06, 2001 PERFO RM ING LABO RATO RY / TESTIN G FA C ILITY Centre Analytical Laboratories, Inc.

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TestResults V, : , ;j A R 2 2 6 -2 1 1 7 fik:///Cl/WINDOWS/TEMP/C-8-FC143ter 1-1-70thru8-9-0l.htm \ TestResults Sample Date Range C oncentration Range A ction Level Industrial Hygiene 1/1/70 100% 8/9/01 Sample Dt Sample # D uration Type Employee Name Pers BTO : 08 TEFLON LOC : 100 P/S - MONOMER OPERATOR CONTROL ROOM (08PA/PB/PC) 5/10/99 33692 360 P BARROW, THOMAS L 08PH Chemical Cone U nit Percent C-8/FC-143 <0.01 MPB 1.8% X....S 1of 99 BTO : 08 TEFLON LOC : 101 P/S - TF FIELD OPERATOR (08PA) 1/30/98 27147 360 P LEWIS, JEFFREY BOYD 08PA 2/5/98 27150 360 P SPAUR, MICHAEL E 08PA 8/10/98 27989 360 P PARSONS, TROY ALAN 08PA 11/18/98 28543 360 P 08PA 2/8/99 28855 360 P 08PA 6/3/99 33689 360 P GOBEL, STUART J 08PA 9/9/99 34048 12/15/99 34415 360 P ESKINS, ROBERT M 08PA 360 P DELLINGER, JAMES 08PA 3/6/00 34707 360 P COX.

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AR226-2335 \ & Ann K M asse 06/08/2003 06:30 PM To: Irene A Legiec/AE/DuPont@DuPont, Catherine A Barton/AE/DuPont@DuPont, Charles J Zarzecki/AE/DuPont@DuPont cc: Subject: M A S S BA LA N C E TEAM - EN V IRO N M EN T AL SA M P L IN G T his will be a good meeting for you to attend.

Fluoropolymers Monitoring Technical Group September 18,2003 AR226-2339 EXP000593 Agenda Program Overview - EPA Suggested Priority Change Discussion Landfills Soil Sampling Biota Sampling Possible Sources of Exposure EXP000596 APFO M anufacture // Fluoropolymer Summary Processing * Articles of Commerce EXP000597 APFO Manufacture 99% Reduction in emissions as compared to prior manufacture Air dispersion modeling Water monitoring - Prior Manufacturer - New technology baseline Program Plant Design LOI LOI/other LOI Timing In place Complete Ongoing Ongoing >99% Emissions Rduction APFO M anufacture Air Dispersion Modeling Water Monitoring Fluoropolymer Summary Processing Articles of Commerce EXP000598 LOI ECA \c Non-Fluoropolymer Products Program Timing Commitment to not sell APFO outside fluoropolymer industry LOI Ongoing EXP000599 >99% Emissions Reduction APFO M anufacture Air Dispersion Modeling Water Monitoring Fluoropolymer Summary Processing - Fluoropolymer M anufacture * Dry Resin Processing Articles Aqueous R esin Processing * of Commerce EXP000600 LOI ECA Fluoropolymer Manufacture Global Material Balance 50% Emissions Reduction Commitment 2002 Status - 48% reduction from the baseline Monitoring/Modeling Commitments - Air dispersion modeling - Groundwater - Soil - Landfill Program pre-LOI pre-LOI LOI LOI/other Other Other Timing Complete 2006 12/31/03 Ongoing (Today) (Today) >99% E m ission s Reduction APFO M anufacture Air Dispersion M odeling Water Monitoring Fluoropolymer Summary >50% Emissions Reduction Fluoropolym er M anufacture Air Dispersion M odeling Water Sampling/ Monitoring EXP000602 LOI ECA Processing/Articles o f Commerce Program Timing Articles of commerce testing - "New " Articles of Commerce - "Aged" Articles of Commerce Dispersion processors material balance Incineration testing LOI ECA LOI ECA 12/31/03 2004 12/31/03 6/30/04 0CPOOO6Q4 >99% E m ission s Reduction APFO M anufacture AnDispersion M odeling Water Monitoring LOI EGA Fluoropolymer Summary >50% Emissions Reduction Fluoropolym er M anufacture Air Dispersion M odeling Water Sampling/ Monitoring ---------------------------------------------------------------------------- Articles o f Commerce Testing Dispersion Processors Material Balance Aged Articles o f Commerce Testing Incineration Testing EPA Proposal Delay "Articles of Commerce" testing and goal date and accelerate "Air dispersion modeling" at Fluoropolymer manufacturing sites in order to expedite the process to determine if additional monitoring (and ECA) is needed at these facilities.

AR226-2344 ATTACHMENT 2 SEPTEMBER 2002 THROUGH AUGUST 2003 AIR DISPERSION MODELING ANALYSIS OF APFO EMISSIONS DuPPoanrtkWerassbhuinrgg,toWneWst oVrikrsgiFnaiacility Prepared for: West VirginiaCD7heD0ap1riav2lreiMstsimtooanencn,CotWfooArVfkiErl2enQ5Av3ui0vra4oel-,ni2tSmy9E4e3ntal Protection Prepared by: DuPont EWEnngilvimnireionengrmitnoegnn,TtDaelEcShen1co9tl8ioo9gn8y (DuET) October 17,2003 ASH027184 EXP015749 September 2002MTohdreoluingghAAnualgyussist2o0f0OA3PcAtFoiOrbDeErims1p7ies,2rssi0oio0nn3s 1.

Ohio EPA December 2,2003 ks o to CO o Ul AR226-2350 EXP01582Q O b jectives Provide grounding/update on recent activities Solicit input on upcoming activities 'H****** 8O1000 o <j\ EXP015821 Agenda Water - GIST Final Report Recommendations - Proposed MOU Based on GIST Recommendations - OEPA Requests - DuPont Suggested Modifications Air - Review Recent M odel Results g - Air Permit Update I - Additional Reduction Programs - Air Model Verification Plan EXP015822 Proposed Memorandum of Understanding-West Virginia DEP and Ohio EPA Summary of Activities December 2, 2003 m oxo cUol ASH028048 GIST Report Recommendations Summary Final GIST report issued August, 2003 Continued quarterly/annual monitoring of certain Ohio River public water systems Quarterly/annual monitoring of private water supplies (10 locations) in West Virginia and Ohio - West Virginia: Wash Works 0-2 mile radius and Dry Run Landfill/Letart Landfill 1-mile radius - Ohio: Wash Works 0-2 mile radius - List to include wells, springs, cisterns Conduct C8 monitoring at all DuPont Washington Works facilities according to applicable West Virginia Solid Waste/NPDES, NPDES, g and EPA HSWA (Corrective Action) permit requirements to GO o EXP015824 Proposed MOU -Administrative Details Parties: - West Virginia Department of Environmental Protection - West Virginia Department of Health and Human Resources - Ohio Environmental Protection Agency - E.I. du Pont de Nemours & Company i Objectives: - Continued monitoring and reporting of C8 concentrations in groundwater and surface water - Implement recommendations of the GIST concerning continued sampling and monitoring in WV & Ohio ("in and around the g facilities") g00 - Begin first quarter 2004 o w o E X P 0 1 5825 Proposed MOU -Public Water Syste II Sampling WV Public Water Systems: - Quarterly sampling 1Q2004-4Q2005 at Lubeck PSD, DuPont WW, and GE production wells and finished water (if applicable) - Annual sampling 2004-2005 at Blennerhassett Island State Park, Mason Cty.

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AR226-2595 [Andrew S H a r d e n __________ _______ 08/23/2002 02:40 PM j To: M.

AR226-2815 SPONSOR APME Avenue E. van Niewenhuyse 4 BOX 3 B-l 160 Brussels Belgium TESTITEM AMMONIUM PERFLUOROOCTANOATE (APFO) STUDY TITLE ALGAL INHIBITION TEST DATA REQUIREMENT Directive 92/69/EEC C.3,31st July 1992 OECD Guideline No. 201, 7th June 1984 US EPA/OPPTS 850.5400 Guidelines, April 1996 STUDYDIRECTOR Jacques LUaridon EXPERIMENTAL COMPLETIONDATE 7 March 2003 DATE OFISSUE J<G <eo(^ TEST FACILITY CIT BP 563 - 27005 Evreux - France LABORATORYSTUDY NUMBER 23685 EAA IFM Recherche S.N.C. au Capital de 846.092 7 0 8 0 6 0 46 2 R.C.S.