Document ykNazy317B2j5znBzddv20xrd

mm-onaBESTCOPY AVAIlABLE Ji:i 1lillSON Ml OK ' : o n i . m o u vs j i : 11tn; l R E C E IV E D Daniel Baugh Institute of Anatomy Department o f Anatomy Offiee o f the Director and Chairman mC5& .. NOV 2 v 1332 TOXIC3iOVlLO 3V Philadelphia, 19107 (215) 928-7820 November 19, 1982 Dr. Franklin D. Griffith Toxicology Services Medical Department 220-2E-02 3M Center St. Paul, Minnesota 55144 Dear Dr. Griffith: I have carefully reviewed the developmental toxicology safety evaluation studies of FC143. This substance has been adequately tested in pregnant rats and rabbits treated by two routes of administration. From the results of these studies, one.clearly concludes that FC143 poses no hazard to the concepta even at dose levels sufficiently high to produce overt toxicity in the dams. In view of these facts, there is no need for further developmental toxicology testing of FC 143 in my opinion. Sincerely, EMJ:sp cc: W.C. McCormick, III ^ E. Marshall Jo i, Ph.D. Professor and firman Director, Danle Baugh Institute of Anatomy C03113