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Submitted to: BIOSEARCH, INC.

PiR11-OM30 CO RN ING Hazleton MUTAGENICITY TEST ON T-6564 IN AN IN VIVO MOUSE MICRONUCLEUS ASSAY FINAL REPORT AUTHOR Hemalatha Murli, Ph.D.

/IR tf -O 1 BIODEGRADATION (BOD/COD/TOC) TEST SUBSTANCE Identity: Perfluorooctanoic acid, ammonium salt; may also be referred to as PFOA ammonium salt, Ammonium perfluorooctanoate, PFO, FC116, FC-126, FC-169, or FC-143.

CAS Number 754-91-6 3M Company M 6_T77 Voluntary Use and Exposure Information Profile Perfluorooctane sulfonamide I.

C O V M C ^ THE DEVELOPMENT SE R V IC E S COMPANY ORIGINAL SRPT /M a*c-0?

3M 6S1t.2P7a3u3l, 1M11N055144-1000 fofL Z.Z -- lOetlf.

A 2-26 _ l06Lf Handling of FLUOROPOLYMER RESINS 3rd Edition Published by the Fluoropolymers Division of The Society of the Plastics Industry, Inc.

RECEIVE^ oppt cbe 2003 OCT 2 9 AH IP 01 AR226-1542 STATUS REPORT COMBINED REPEATED DOSE TOXICITY STUDY WITH REPRODUCTION/DEVELOPMENTAL TOXICITY SCREENING TEST WITH T-7601 ADMINISTERED BY ORAL GAVAGE IN WISTAR RATS November 4,2003 8:25AM NOTOX Project 385717 NOTOX Substance 113769/B Page 1 of 7 T-7.601 NOTOX Project 385717 Study start: Start mating: Necropsy of males Delivery of litters Necropsy of females and pups Allocation: Group 1 2 3 4 Dose level mg/kg b.w.

AR226-1741 Toxicological Summary PFOS Dietary Chronic Definitive Reproductive Study: Mallard Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro, potassium salt.

Multiple Chemicals 3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 ENVIRONMENTAL STUDIES Click on Study Title to View Report PAGE 1 Environmental Monitoring 1.

Multiple Chemicals 3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 ENVIRONMENTAL STUDIES Click on Study Title to View Report PAGE 1 Environmental Monitoring 1.

PFOA 3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Click on Study Title to View Report Perfluorooctanoic acid PAGE 1, 2 Pharmacokinetic Study 1.

3M FLUOROCHEMICAL SUBMISSIONS February, 2002 - May, 2004 INDEX OF 3M'S 2002-2004 AR-226 DOCKET SUBMISSIONS BY DATE Back to Menu APRIL 2002 Click on Study Title to View Report April 2, 2002 April 2, 2002 Submission Cover Letter Final Report, Oral (Gavage) Two-Generation (One Litter per Generation) Reproduction Study of Ammonium Perfluorooctanoate (APFO) in Rats, Sponsor's Study Number: T-6889.6, March 26, 2002.

Northwest Bioanalytical Study No.