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BACK TO MAIN 3M Company Page 1 of 32 FINAL REPORT Epidemiology, 220-3W-05 Medical Department 3M Company ______________________ St. Paul, MN 55144____________________ Date: March 19,2001 Title: Descriptive Summary of Serum Fluorochemical Levels among Employee Participants of the Year 2000 Decatur Fluorochemical Medical Surveillance Program Study Start Date: March 1,2000 Protocol Number (not applicable) IRB Approval Exempt Expedited X IRB Approval Date: (not applicable as these data are from a medical surveillance program) Principal Investigator: Co-investigators: Study Director: Geary W. Olsen, D.V.M., PhD .1 Perry W. Logan, M.S.2 Cathy A. Simpson, R.N.2 Jean M. Burris, R.N., M.P.H.1 Michele M. Burlew, M.S.1 James K. Lundberg, Ph.D.3 Jeffrey H. Mandel, M.D., M.P.H.1 Jeffrey H. Mandel, M.D., M.P.H.1 1. 3M Medical Department, 220-3W-05, St. Paul, MN 55144-1000 2. 3M Dedatur, EHS&R, P.O. Box 2206, Decatur, Alabama 35609-2206 3. 3M Environmental Laboratory, 2-3E-01, St. Paul, MN 55144-1000 Page l BACK TO MAIN ABSTRACT 3M Company Page 2 of 32 Serum fluorochemical levels were measured for 263 Decatur chemical plant and site employees during the year 2000 fluorochemical medical surveillance program. Except for perfluorooctanoate (PFOA), serum fluorochemical levels were comparable to those reported in a 1998 random sample of 126 Decatur chemical plant and site employees. For example, for all employee participants the serum perfluorooctanesulfonate (PFOS) geometric mean level was 0.94 ppm (95% confidence interval (Cl) 0.82-1.02) in 2000 compared to 0.91 ppm (95% Cl 0.79-1.13) in 1998. However, the serum PFOA geometric mean increased to 1.13 ppm in 2000 (95% Cl 0.99 1.30) from 0.90 ppm (95% Cl 0.72-1.12) in 1998. The largest increase in serum PFOA levels was observed among cell operators whose geometric mean level was 4.12 ppm (95% Cl 2.91-5.84) in 2000 compared to 1.43 ppm (95% Cl 0.42-4.83) in 1998. This was likely due to the increased production of perfluoorooctanoic acid that has occurred at the Decatur site since 1999. Chemical operators engaged in fluorochemical production activities in Building 3 had, on average, higher serum fluorochemical levels than chemical operators and mill operators engaged in Dyneon production activities in Buildings 4,38,51 and 61. For example, chemical operators who worked on the monomer team in Building 3 had PFOS and PFOA geometric mean levels of 2.23 (95% Cl 1.68-2.95) and 3.64 (95% Cl 3.04-4.34), respectively, whereas mill operators in Building 61 had geometric mean levels of 0.69 (95% Cl 0.58-0.83) and 1.32, respectively. There were five employees whose serum PFOA levels exceeded the 3M BiologicaTLimit Value (BLV) of 5 ppm. The highest value was 12.70 ppm. Page 2 BACK TO MAIN 3M Company Page 3 of 32 INTRODUCTION The 3M Decatur fluorochemical medical surveillance program is conducted on a biennial basis. Prior to 1995, total organic fluorine was routinely measured. Serum perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) were assayed in 1995 and 1997 at the Decatur chemical plant (Olsen et al, 1999a). Because the voluntary nature of the medical surveillance program may not provide for a complete understanding of the distribution of serum fluorochemical levels in the Decatur workforce, a random sample of 232 employees was selected for fluorochemical testing in the Fall, 1998. A total of 180 employees (80%) participated (126 chemical plant and 60 film plant employees). These random sample findings have been reported, in detail, elsewhere (Olsen et al, 1999b). The purpose of this report is to provide the results from the year 2000 fluorochemical medical surveillance program and relate these data to previous research, in particular, the 1998 random sample survey. METHODS The fluorochemical medical surveillance program is available, on a voluntary basis, to Decatur chemical plant employees and those site employees who may work in the chemical plant area. Approximately 500 Decatur chemical plant and site employees were eligible to participate; 263 participated. Four film plant employees also requested their blood be tested for fluorochemical levels; their findings are not presented in this report. In addition to the fluorochemical testing program, a standard battery of clinical chemistry^ pulmonary function and urinalysis tests are performed on employees. A group analysis of these clinical data will be reported in conjunction with employee data from Page 3 BACK TO MAIN 3M Company Page 4 of 32 the Antwerp manufacturing plant's 2000 fluorochemical medical surveillance program. This report focuses solely on the employees' serum fluorochemical levels in relation to self-reported responses from a work history questionnaire (see Appendix A) that was administered at the time of the blood collection in the Spring, 2000. Sera samples were extracted using an ion-pairing extraction procedure. The extracts were quantitatively analyzed for PFOS (perfluorooctanesulfonate), PFOA (perfluorooctanoate, which is also known as C8 acid or POAA), PFHS (perfluorohexanesulfonate), PFOSAA (N-ethyl perfluorooctanesulfonamidoacetate), M570 (N-methyl perfluorooctanesulfonamidoacetate), PFOSA (perfluorooctanesulfonateamide) and M556 (perfluorooctanesulfonamidoacetate) using high-pressure liquid chromatography/electrospray tandem mass spectrometry (HPLC/ESMSMS) and evaluated versus an extracted curve from a human serum matrix. Endogenous levels of certain fluorochemical were determined in the standard serum matrix and additional fluorochemical was spiked into the matrix. The total amount of each specific fluorochemical (endogenous + spiked) was used to construct an extracted standard curve. All serum fluorochemical analyses were determined by Northwest Bioanaltyical Laboratory Inc. (Salt Lake City, UT). Employee work history questionnaire data were computerized. A review of the employees job titles by an industrial hygienist (PWL) and an epidemiologist (GWO) categorized the employees' self-reported job titles into eight job classifications: cell operators, chemical operators, engineers/laboratory workers, maintenance, mill operators, waste operators, administrative assistants and managers. These eight job classifications were nearly comparable to those used in the 1998 random sample analysis. The one Page 4 BACK TO MAIN 3M Company Page 5 of 32 difference was that crew supervisors and team leaders that were categorized in the supervisor/manager job classification in 1998 were categorized in the chemical operator category in 2000. Although the job tasks did not change, the term "secretaries" which was used as a job classification in 1998 was defined as "administrative assistants" in 2000. Because the serum distributions for PFOS, PFHS, PFOA, PFOSAA, M570, PFOSA and M556 appeared log normally distributed (see Figures 1 and 2 for PFOS and PFOA), natural log transformations of the fluorochemicals were performed to calculate geometric means [e(sumlnx)/n)] and 95% confidence intervals were calculated for the geometric mean. The random variable X is said to have a log normal distribution if log X is normally distributed, that is, if X is of the form eYwhere Y is normal (i.e., the normal bell shaped curve). The pertinent properties of a log normal distribution can then be derived from properties of the normal distribution. The mean and variance are of the normally distributed Y, that is, of log X. All employee serum values for PFOS, PFHS, PFOA and M570 were above the respective lower limit of quantitation (LLOQ). There were 8 employees who with PFOSAA were determined to be below the LLOQ (0.006 ppm); 111 employees were below the LLOQ for PFOSA (0.001 ppm); and 13 employees were below the LLOQ for M556 (0.0043 ppm). For statistical purposes, serum fluorochemical values that were less than the LLOQ were assumed to be the midpoint between zero and the LLOQ. Therefore, employees with serum values reported at below the LLOQ for PFOSAA, PFOSA afid M556, were assigned the values 0.003 ppm, 0.0005 ppm and 0.00215 ppm, respectively. All fluorochemical measurements were reported in parts per million (ppm) Page5 BACK TO MAIN 3M Company Page 6 of 32 to the second dcimal point (or to the 3rd or 4* dcimal point if the LLOQ was at the 3rd dcimal point). RESULTS Provided in Table 1 are the summary statistics for the 263 chemical plant and site employees) who participated in the year 2000 fluorochemical medical surveillance program. Also provided are the previously reported findings from the 126 chemical plant and site employees who participated in the 1998 random sample survey. The 95% confidence interval of the geometric mean was nearly identical for the two sets of data. There were 113 employees who participated in both the year 2000 fluorochemical medical surveillance program and in the 1998 random sample study. Figures 3 ,4 and 5 show the categorical differences between these two time periods for serum PFOS, PFOA and PFHS levels. The mean difference (i.e., arithmetic average of the individual's 2000 fluorochemical-specific data minus their 1998 data) between these employees' serum PFOS, PFOA and PFHS values were (95% confidence interval in parenthesis): -0.13 ppm (-0.27 to +0.02), +0.21 ppm (+0.06 to +0.36) and -0.01 ppm (-0.04 to +0.01), respectively. The demographic distribution of the eight major job classifications is found in Table 2. As expected, participants were predominately male, and mill operators were the youngest employees because of their entry level position at the Decatur facility. Presented in Table 3 are the arithmetic mean, range, geometric mean and the 95% confidence interval of the geometric mean of the seven fluorochemicals for the eight major job classifications. [Note: Provided in Appendix B is a comparable table from the Page 6 BACK TO MAIN 3M Company Page 7 of 32 1998 random sample study.] Cell operators, chemical operators and maintenance workers had significantly higher serum PFOS levels than engineer/lab workers, mill operators, administrative assistants and managers. Cell operators had significantly higher geometric mean serum PFOA and PFHS levels than all other job classifications. Chemical operators and maintenance workers had significantly higher PFOSAA, M570, PFOSA and M556 geometric mean levels than most of the other job classifications. Regardless of work location, the 95% confidence intervals for serum PFOS and PFOA overlapped for chemical operators who worked primarily in Building 3 (Table 4). Geometric mean levels of M570, PFOSAA and M556 were higher for chemical operators who worked exclusively in Building 3 compared to those who spent time working in Buildings 3 ,4N and 42. PFHS levels were comparable regardless of work location within Building 3. Analyzed by the teams that these employees self-reported on their work history questionnaires, higher serum PFOA levels were observed among chemical operators in rm < rm the alcohol, monomer, Scotchban and Scotchgard teams than in the cell feed and lightwater teams (Table 5). The alcohol and monomer teams had significantly higher geometric means for M570. PFHS levels were comparable regardless of the work team. Among chemical and mill operators who worked primarily in DyneonTM production operations which included work in Buildings 4, 38, 51 and 61, geometric mean serum fluorochemical levels were lower (Table 6) than those reported by chemical operators who worked primarily in Building 3 operations (Table 4). The Dyneon building 4 team had lower serum PFOS, M570 and M556 levels than the Building 4 inert and FC teams. Page 7 BACK TO MAIN 3M Company Page 8 of 32 Maintenance workers were requested to self-report their job descriptions as either day mechanic, day electrician, shift mechanic or shift electrician. Geometric mean serum fluorochemical levels were higher among the mechanics than the electricians (Table 8). DISCUSSION The year 2000 serum PFOS levels were comparable to the distribution observed in the 1998 random sample study. The geometric mean serum PFOS level was 0.91 ppm in 2000 compared to 0.94 ppm in 1998. The highest serum PFOS value measured in 2000 (10.06 ppm) was of the same person who had the highest serum PFOS value measured in 1998 (10.60 ppm). Serum PFOA levels were higher among cell operators in 2000 due to the increased production of perfluorooctanoic acid that occurred beginning in 1999 at the Decatur chemical plant. The geometric mean level of serum PFOA was 1.43 ppm (95% Cl 0.42-4.83) among the cell operators tested in 1998 compared to 4.57 ppm (95% Cl 1.85-7.99) among the cell operators tested in 2000. The other serum fluorochemical levels, by major job categories, were comparable between the two time periods. Five employees had serum PFOA levels greater than the 5 ppm Biological Limit Value (BLV) that was established by the 3M Exposure Guideline committee in 2000. The highest value was 12.70 ppm for a chemical operator on the Scotchgard team. The other 4 employees had serum PFOA levels that ranged between 5 and 9 ppm. Two of these four employees were cell operators and the other two employees worked on the Building 3 Scotchgard and monomer teams where production and/or use of perfluorooctanoic acid does not occur. Interestingly the inert team in Building 4 does Page 8 BACK TO MAIN 3M Company Page 9 of 32 have occupational exposure to perfluorooctanoic acid but this team's operators' serum PFOA levels on this inert team were lower than those reported for employees on the Building 3 alcohol, monomer, Scotchgard and Scotchban teams where production and/or use of perfluoroctanoic acid does not occur. An industrial hygienist (PWL) will further evaluate this issue. Employees who participated in the year 2000 fluorochemical medical surveillance program received a personal letter with their individual results for the seven fluorochemicals measured. In addition, if the employee participated in the 1998 random sample study, he/she was also provided a copy of the letter from this study. Group employee communications occurred on December 11 and 12, 2000 where these analyses, as described in this report, were presented. Page 9 BACK TO MAIN REFERENCES 3M Company Page 10 of 32 Olsen GW, Burris JM, Mandel JH, Zobel LR (1999a). Serum perfluorooctane sulfonate and hepatic and lipid clinical chemistry tests in fluorochemical production employees. JOEM 41(9):799-806. Olsen GW, Logan PW, Simpson CA, Hansen KJ, Burris JM, Burlew MM, Schumpert JC, Mandel JH (1999b). Fluorochemical exposure assessment of Decatur chemical and film plant employees. St. Paul:3M Company (unpublished report). .j' Page 10 BACK TO MAIN Figure 1 Year 2000 Decatur Fluorochemical Medical Surveillance Number of Employees (N = 263) by Serum PFOS Levels (ppm) (Each x axis tick represents 0.1 ppm) 3M Company Page 11 of 32 Serum PFOS Level (ppm) BACK TO MAIN Figure 2 Year 2000 Decatur Fluorochemical Medical Surveillance Number of Employees (N = 263) by Serum PFOA Levels (ppm) 3M Company Page 12 of 32 BACK TO MAIN 3M Company . Page 13 of 32 Figure 3 Serum PFOS Difference (ppm) Among Those Employees Who Participated in the Year 2000 Decatur Fluorochemical Medical Surveillance Program and the 1998 Random Sample Study \ Difference in ppm Serum PFOS (2000 minus 1998) BACK TO MAIN 3M Company Page 14 of 32 Figure 4 Serum PFOA Difference (ppm) Among Those Employees Who Participated in the Year 2000 Decatur Fluorochemical Medical Surveillance Program and the 1998 Random Sample Study \ Difference in ppm Serum PFOA (2000 minus 1998) BACK TO MAIN Figure 5 Serum PFHS Difference (ppm) Among 113 Employees Who Participated in the Year 2000 Decatur Fluorochemical Medical Surveillance Program and the 1998 Random Sample Study 3M Company Page 15 of 32 Difference in ppm Serum PFHS (2000 minus 1998) BACK TO MAIN TABLE 1 3M Company Page 16 of 32 Year 2000 Decatur Fluorochemical Medical Surveillance Program Comparison of Year 2000 Serum Fluorochemical Level (ppm) Data (N = 263) and Year 1998 Random Sample Data (N = 126) Fluorochemical PFOS PFOA PFHS PFOSAA M570 PFOSA M556 V ............... Arithmetic Mean 1.32 1.78 0.30 0.06 0.25 0.003 0.08 2000 Geometric Range Mean 0.06-10.06 0.91 0.04 -12.70 1.13 0.007-1.67 0.18 0.003 - 0.44 0.04 0.008-2.31 0.11 0.0005-0.02 0.002 0.002-0.57 0.04 95% C.I. 0.82-1.02 0.99-1.30 0.16-0.21 0.001 -0.04 0.10-0.13 0.001-0.02 0.03-0.05 Arithmetic Mean 1.51 1.54 0.35 0.02 0.15 0.06 0.05 1998 Geometric Range Mean 0.09 -10.60 0.94 0.02-6.76 0.90 0.005-1.88 0.18 0.001-0.27 0.008 0.008 - 0.99 0.08 0.001-0.61 0.01 0.001-0.41 0.02 95% C.I. 0.79-1.13 0.72-1.12 0.15-0.22 0.006-0.01 0.07-0.10 0.009-0.02 0.02 - 0.03 BACK TO MAIN 3M Company Page 17 of 32 TABLE 2 Year 2000 Decatur Fluorochemical Medical Surveillance Program Demographics of Decatur Chemical Plant Employees by Eight Major Job Categories \ Cell Operator Chemical Operator Maintenance Mill Operator Waste Operator Engineer/ Laboratory Administrative Assistants Managers* Number 8 128 29 22 4 57 4 11 Age (yrs) 47.6 41.9 43.2 38.5 52.3 43.1 44.5 46.2 Gender Male (%) 8(100) 104 (81) 28 (97) 17 (77) 4(100) 46 (81) 0(0) 8(73) Female (%) 0(0) 24 (19) 1(3) 5(23) 0(0) 11(19) 4(100) 3(27) Average Year Started Current Job 1995 1991 1990 1997 1992 1991 1990 1995 Body Mass Index 26.0 29.3 28.2 28.5 27.7 27.9 24.3 28.3 BACK TO MAIN TABLE 3 3M Company Page 18 of 32 Year 2000 Decatur Fluorochemical Medical Surveillance Program Mean, Range, Geometric Mean and 95% Confidence Interval of Geometric Mean of Serum Fluorochemical Levels (ppm) by Eight Major Job Categories \ Cell Operator8 ____ (N = 8) PFOS Arithmetic Mean Range 1.71 0.87-2.89 Chemical Operatorb (N = 128) 1.72 0.18-4.17 Geometric Mean 95% C.I. PFOA Arithmetic Mean Range Geometric Mean 95% CL PFHS Arithmetic Mean Range Geometric Mean 95% C.I. PFOSAA Arithmetic Mean Range 1.57eAfth 1.16-2.13 1.39CAfth 1.23 -1.58 4.57 1.85-7.99 2.45 0.10-12.70 4 i2b,c,d,e,tg,h 2 99.d.e,Cg.h 2.91 - 5.84 1.75-2.27 0.78 0.17-1.43 0 67b->d'e-f-&h 0.43 -1.05 0.39 0.02-1.67 0 30a''d'e.i&h 0.27-0.35 0.01 0.003-0.03 0.10 0.003-0.44 0 ?1 00 p % ^g Geometric Mean 95% C.I. M570 Arithmetic Mean Range 0.01b'd 0.0004-0.02 0.07 0.03-0.23 0.40 0.01-2.31 Geometric Mean 95% CL 0.05b,d 0.03-0.09 0 20<w'&h 0.16-0.25 Engineer/ Labc (N = 57) 0.64 0.06-2.95 0.43a,b'd,e 0.34-0.56 0.53 0.04-2.10 0.36a'b,d,e'f 0.29-0.46 0.17 0.01-0.70 0.10a'b,d 0.07-0.13 0.02 0.003-0.08 0.02b,d 0.005-0.02 0.08 0.008 - 0.47 0.05b'd 0.04-0.06 Maintenanced (N = 29) Mill Operator* (N = 22) Waste Operato/ (N = 4) 1.57 0.11-10.06 1.12CA&h 0.83 -1.50 0.72 0.31-1.56 0.688,b,d 0.58-0.79 1.10 0.45 -1.88 0.89 0.42 -1.91 1.53 0.06-4.03 1 I2a,b-C,g,h 0.80-1.57 1.35 0.50-2.49 1.30a*,c* h 1.14-1.47 1.55 0.46-2.25 1 .3 3 ^ 0.65-2.73 0.25 ' 0.02-1.05 0.16a,b,c,e 0.12-0.23 0.07 0.03-0.13 0.07a,b,d 0.06-0.08 0.24 0.02-0.66 0 .128,b 0.03-0.53 0.07 0.008-0.39 0.02 0.01-0.04' 0.05a'b,c,e,ig-h 0.02b,d 0.001-0.07 0.004-0.02 0.01 0.01-0.02 0.01bd 0.001-0.02 0.28 0.02-0.94 0.05 0.02-0.12 0.20a'CA&h 0.04b>d 0.14-0.28 0.04-0.05 0.09 0.05-0.17 0.08 0.05-0.15 Administrative Assistant8 (N = 4) Manage/ (N = 11) 0.53 0.32-0.90 0.498,b,d 0.30-0.78 0.66 0.19-2.57 0.458*m 0.27-0.75 0.38 0.10-0.78 0.30a'b,d,e,f 0.12-0.71 0.58 0.16-1.94 0.42'w 'f 0.26-0.68 0.11 0.05-0.21 0.09a,b 0.05-0.19 0.18 0.02-0.77 O.IO8^ 0.05-0.20 0.02 0.01-0.02 0.02b,d 0.0003-0.02 0.02 0.008-0.04 0.02m 0.0006 - 0.03 0.07 0.02-0.11 0.05b,d 0.03-0.12 0.07 0.02-0.16 0.05b,d 0.03-0.09 TABLE 3 (continued) PFOSA Arithmetic Mean Range 0.0007 0.0005-0.002 Geometric Mean 0.0007b'd,e 95% C.I. 0 .0 0 0 5 -0.001 M556 Arithmetic Mean Range 0.03 0.008-0.06 Geometric Mean 95% C.I. 0.02b>d 0.01-0.04 0.004 0.0005-0.02 0.0009 0.0005-0.009 0.002a'CA&h 0.0007b,d,e 0.002-0.003 0.0006 - 0.0008 0.13 0.0002-0.57 0 03a'c,e,&h 0.01-0.09 0.03 0.002-0.18 0.02b,d 0.01-0.02 0.004 0.0005-0.02 0.002a'Afeh 0.001-0.003 0.10 0.002-0.36 0.06a,c,e,g'h 0.04-0.09 (a-h), comparisons for each current job category using student's t, p < 0.05 BACK TO MAIN 3M Company Page 19 of 32 0.006 0.0005-0.01 0.002 0.0005 0.001 0.0005-0.002 0.0005 - 0.0005 0.0005 - 0.004 0.005a>b,oAfeh o.oor 0.0005bd'e 0.0009b<u 0.004-0.007 0.0007 - 0.003 0.0005-0.0005 0.0005 - 0.001 0.02 0.002-0.07 0.02b,d 0.01- 0.02 0.03 0.01-0.05 0.03b,d 0.02-0.05 0.02 0.006-0.03 0 . 0 1 b>d 0.007 - 0.03 0.02 0.005-0.07 0.02b,d 0.01-0.03 BACK TO MAIN TABLE 4 3M Company Page 20 of 32 Year 2000 Decatur Fluorochemical Medical Surveillance Program Arithmetic Mean, Range, Geometric Mean and 95% Confidence Interval of Geometric Mean of Serum Fluorochemical Levels (ppm) by Building 3 Area for Chemical Operators LOCATION Building 3 (N -21) v Arith. Mean Range G. Mean 95% C.I. Building 3 (OSCL/OSF area) (N = 10) Arith. Mean Range G. Mean 95% C.I. Building 3 (besides OSCL/OSF area) (N = 18) Arith. Mean Range G. Mean 95% C.I. 3 !1 /L1 Building 3 (besides OSCL/OSF area), Building 4N and Building 42 Arith. Mean Range G. Mean 95% C.I. Building 3 (OSCL/OSF area) Building 4N, Building 42 (N -4) Arith. Mean Range G. Mean 95% C.I. PFOS 2.51 1.40-4.17 2.38 2.06-2.74 2.28 0.97-3.67 2.10 1.58-2.77 2.28 0.48-3.80 2.05 1.60-2.63 1.65 0.74 - 2.04 1.55 1.07-2.26 2.10 1.32-3.93 1.89 1.15-3.11 PFOA 3.35 1.28-5.41 3.18 2.73-3.69 2.99 1.23-4.73 2.70 1.97-3.69 3.85 1.93-12.70 3.40 2.72-4.24 2.20 1.20-3.03 2.10 1.52-2.90 1.93 1.17-2.85 1.82 1.21-2.73 PFHS 0.46 0.23 - 0.80 PFOSAA 0.15 0.05 - 0.44 0.43 0.37-0.51 0.13 0.005-0.16 0.53 0.13-1.67 0.10 0.04-0.27 0.40 0.25 - 0.65 0.09 0.004-0.12 0.46' 0.06-0.84 0.14 0.04 - 0.38 0.38 0.26 - 0.54 0.12 0.005-0.16 0.58 0.13-1.04 0.04 0.02-0.06 0.44 0.03 0.20-1.00 0.0007-0.05 0.58 0.34-0.92 0.10 0.03-0.26 0.53 0.07 0.32-0.88 0.0005-0.17 M570 0.87 0.35-2.31 PFOSA 0.008 0.002-0.02 M556 0.27 0.12-0.47 0.77 0.006 0.25 0.62-0.96 0.004 - 0.008 0.20-0.29 0.70 0.006 0.22 0.21 - 1.26 0.002-0.01 0.008-0.44 0.61 0.005 0.19 0.42-0.89 0.004 - 0.008 0.13-0.27 0.87 0.008 0.11 -2.30 0.002 - 0.02 0.24 0.04-0.57 0.71 0.006 0.20 0.50-0.99 0.005 - 0.009 0.15-0.27 0.17 0.002 0.07 0.07-0.33 0.0005 -0.004 0.004-0.09 0.15 0.001 0.06 0.09-0.25 0.0004-0.003 0.04-0.09 0.17 0.002 0.11 0.12-0.24 0.0005-0.003 0.05-0.24 0.16 0.001 0.09 0.12-0.22 0.0006-0.003 0.04-0.18 BACK TO MAIN TABLE 5 3M Company Page 21 of 32 Year 2000 Decatur Fluorochemical Medical Surveillance Program Arithmetic Mean, Range, Geometric Mean and 95% Confidence Interval of Geometric Mean of Serum Fluorochemical Levels (ppm) by Building 3 Teams for Chemical Operators \ Building 3 Teams Alcohol (N = 7) Arith. Mean Range G. Mean 95% C.I. Monomer (N = 7) Arith. Mean Range G. Mean 95% C.I. Cell Feed (N = 4) Arith. Mean Range G. Mean 95% C.I. Scotchban (N = 5) Arith. Mean Range G. Mean 95% C.I. Scotchgard (N - 6) Arith. Mean Range G. Mean 95% C.I. PFOS 2.84 1.81-3.80 2.75 2.25-3.37 PFOA 3.96 2.14-4.97 3.82 3.02-4.82 PFHS 0.42 0.20 - 0.84 PFOSAA 0.25 0.09-0.44 0.38 0.21 0.26-0.54 0.007-0.34 M570 1.39 0.53-2.31 1.17 0.72-1.92 PFOSA 0.01 0.005 - 0.02 0.01 0.008-0.02 M556 0.32 0.21-0.47 0.30 0.25-0.38 2.36 3.73 0.43 0.17 1.18-3.62 2.64-5.41 0.13-0.70 0.12-0.28 1.18 0.88-1.78 0.006 0.002-0.01 0.31 0.14-0.47 2.23 3.64 0.39 0.16 1.15 0.005 0.28 1.68-2.95 3.04-4.34 0.25-0.59 0.004-0.20 0.96-1.38 0.003-0.009 0.20-0.41 1.94 0.97-3.34 1.76 1.06-2.93 2.22 1.23-2.70 2.12 1.47-3.06 0.47 0.26-0.67 0.43 0.28-0.68 0.06 0.05-0.10 0.06 0.003- 0.08 0.42 0.26-0.60 0.40 0.28-0.56 0.007 0.002 -0.02 0.004 0.002-0.01 0.16 0.08-0.20 0.15 0.10-0.23 2.32 1.29-4.17 2.15 1.47-3.15 3.43 2.58-4.73 3.34 2.66-4.19 0.38 0.14 0.67 0.18-0.73 0.09-0.20 0.47-1.02 0.34 0.13 0.64 0.21-0.55 0.003-0.18 0.49-0.86 0.006 0.003-0.01 0.28 0.13-0.39 0.005 ' 0.25 0.003-0.009 0.17-0.36 2.34 0.48-3.11 2.02 1.12-3.63 5.06 0.51 0.09 1.97-12.70 0.06 - 0.84 0.04-0.15 4.17 0.39 0.09 2.46-7.06 0.18-0.87 0.006-0.13 0.86 0.11-1.17 0.69 0.32-1.48 0.009 0.003-0.01 0.005 0.005-0.01 0.24 0.04-0.35 0.20 0.10-0.38 Lightwater (N = 6) Arith. Mean Range \ G. Mean 95% C.I. Scotchgard and Lightwater (N = 4) Arith. Mean Range G. Mean 95% C.I. Scotchban and Cell Feed (N = 4) Arith. Mean Range G. Mean 95% C.I. TABLE 5 (continued) 2.29 2.78 0.65 1.03-3.41 1.28-4.73 0.12-1.67 2.09 2.54 0.48 1.40-3.11 1.72-3.74 0.24-0.99 2.63 3.52 0.59 1.79-3.20 2.43-4.71 0.56-0.69 2.56 3.40 0.59 1.94-3.38 2.47-4.66 0.53-0.66 2.71 3.36 0.51 1.40-3.95 2.76-3.97 0.39-0.80 2.54 3.32 0.48 1.65-3.91 2.79-3.96 0.35-0.68 BACK TO MAIN 3M Company Page 22 of 32 0.09 0.06-0.11 0.09 0.004-0.10 0.56 0.36-0.90 0.54 0.41-0.70 0.006 0.002-0.01 0.005 0.003 - 0.009 0.22 0.11-0.44 0.20 0.14-0.30 0.13 0.98 0.11-0.18 0.55-1.52 0.006 0.003-0.01 0.28 0.16-0.57 0.13 0.91 0.005 0.24 0.004-0.16 0.59-1.42 0.003 - 0.009 0.13-0.45 0.12 0.68 0.008 0.20 0.06-0.16 0.47 - 0.92 0.002-0.02 0.12-0.32 0.11 0.66 0.006 0.18 0.004-0.18 0.50-0.87 0.002 - 0.02 0.11-0.29 BACK TO MAIN TABLE 3M Company Page 23 of 32 Year 2000 Decatur Fluorochemical Medical Surveillance Program Arithmetic Mean, Range, Geometric Mean and 95% Confidence Interval of Geometric Mean of Serum Fluorochemical Levels (ppm) by Dyneon Production Aras for Chemical Operators LOCATION V, Buildings 4 and 61 (Expander/Dryer) (N =11) Building 4N (Not Expander/Dryer) (N=12) Buildings 4N and 38/51 (N = 9) Buildings 38/51 Buildings 4 and 61 (Expander/Dryer) and Buildings 38/51 (N = 4) Arith. Mean Range PFOS 0^66 0.38-0.91 PFOA 2.43 1.39-4.00 PFHS 0.16 0.07-0.33 PFOSAA 0.10 0.05-0.19 M570 0.07 0.04-0.11 PFOSA 0.002 0.0005-0.005 M556 0.03 0.009 - 0.06 G. Mean 95% C.I. 0.63 2.30 0.14 0.09 0.06 0.002 0.02 0.52-0.77 1.87-2.84 0.10-0.19 0.001-0.12 0.05 - 0.08 0.0009 - 0.003 0.02-0.03 Arith. Mean 1.81 1.43 0.36 Range 0.40-3.64 0.53-2.80 0.09-0.67 0.12 0.03-0.24 0.16 0.002 0.08 0.07 - 0.27 0.0005 - 0.006 0.02-0.22 G. Mean 95% C.I. 1.58 1.30 0.31 0.10 0.14 0.002 1.12-2.21 0.98-1.71 0.21-0.44 0.001-0.14 0.11-0.19 0.001 -0.003 0.07 0.05-0.10 Arith. Mean 1.14 1.64 0.31 Range 0.44-2.71 0.59-3.15 0.14-0.91 0.06 0.04-0.09 0.07 0.0009 0.02 0.03 - 0.08 0.0005 - 0.003 0.01-0.05 G. Mean 95% C.I. 0.93 1.41 0.24 0.03 0.07 0.001 0.02 0.17-3.17 0.97-1.88 0.06-0.42 0.001-0.04 0.03 - 0.08 0.0004 - 0.003 0.006 - 0.10 Arith. Mean 1.82 2.39 0.40 Range 1.33-2.98 1.36-3.85 0.24-0.73 0.09 0.02-0.14 0.09 0.0009 0.03-0.14 0.0005-0.002 0.05 0.01 -0 .0 8 G. Mean 95% C.I. 1.72 2.19 0.37 0.07 0.08 0.0005 1.18-2.49 1.35-3.55 0.23 - 0.59 0.0003-0.17 0.04-0.14 0.0003-0.001 0.04 0.02-0.09 Arith. Mean 0.61 1.87 0.21 Range 0.29-0.83 1.01 -2.44 0.11-0.38 0.08 0.05-0.10 0.05 0.0009 0.02 0.04 - 0.06 0.0005 - 0.002 0.01-0.03 G. Mean 95% C.I. 0.56 1.77 0.19 0.08 0.05 0.0007 0.34-0.91 1.19-2.64 0.11-0.32 0.0005-0.11 0.04 - 0.06 0.0004-0.001 0.02 0.02-0.03 ^--<*\ H TABLE 6 (continued) Buildings 4 and 61 (Expander/Dryer) Building 61 (Millroom) Buildings 38/51 \ (N = 3) Arith. Mean 1.12 1.39 Range 0.18-2.15 1.07-1.86 G. Mean 95% C.I. 0.74 1.35 0.17-3.17 0.97-1.88 0.20 0.07-0.36 0.16 0.06-0.42 Building 61 (Millroom) (Mill Operators) (N = 17) Arith. Mean 0.73 1.39 0.07 Range 0.31-1.56 0.50-2.49 0.03-0.13 G. Mean 95% C.I. 0.69 1.32 0.07 0.58-0.83 1.12-1.56 0.05 - 0.08 BACK TO MAIN 3M Company Page 24 of32 0.03 0.03-0.04 0.03 0.001-0.04 0.02 0.01 -0 .0 4 0.02 0.004-0.02 0.05 0.002 0.04 0.03 - 0.06 0.0005-0.002 0.007 - 0.06 0.05 0.001 0.03 0.03 - 0.08 0.0004 - 0.003 0.006 - 0.10 0.006 0.05 0.02-0.12 0.0005-0.01 0.02 0.008-0.03 0.04 0.004 0.03 - 0.05 0.003 - 0.007 0.02 0.01 -0 .0 2 BACK TO MAIN TABLE 7 3M Company Page 25 of 32 Year 2000 Decatur Fluorochemical Medical Surveillance Program Arithmetic Mean, Range, Geometric Mean and 95% Confidence Interval of Geometric Mean of Serum Fluorochemical Levels (ppm) by Building 4 Teams for Chemical Operators \ Building 4 Teams PFOS PFOA PFHS PFOSAA M570 PFOSA M556 Dyneon (N = 31) Arith. Mean 0.99 2.12 0.25 Range 0.18-2.71 0.59-4.00 0.07-0.91 0.08 0.02-0.19 0.07 0.001 0.03 0.03-0.14 0.0005-0.005 0.007-0.08 G. Mean 95% C.I. 0.81 1.93 0.20 0.07 0.06 0.0009 0.03 0.64-1.02 1.63-2.27 0.16-0.25 0.0008 - 0.08 0.05 - 0.07 0.0007-0.001 0.02-0.03 Inert (N=12) Arith. Mean 1.84 Range 0.70-3.93 2.26 0.54 1.17-4.37 0.13-0.96 0.07 0.02 - 0.26 0.15 0.001 0.08 0.07-0.33 0.0005 - 0.003 0.03-0.24 G. Mean 95% C.I. 1.61 2.12 0.43 0.05 0.14 0.001 0.07 1.18-2.20 1.71-2.63 0.27-0.66 0.0007 - 0.07 0.11-0.18 0.0007 - 0.002 0.05-0.09 FC (N = 16) Arith. Mean 1.68 1.40 0.35 0.11 Range 0.40-3.64 0.53-2.80 0.09 - 0.67 0.03-0.24 0.16 0.003 0.08 0.07-0.27 0.0005-0.001 0.02-0.22 G. Mean 95% C.I. 1.50 1.27 0.30 0.09 1.15-1.94 1.02-1.57 0.22-0.40 0.001-0.13 0.15 0.12-0.18 0.002 0.001 -0.003 0.07 0.05-0.09 BACK TO MAIN TABLE 8 3M Company Page 26 of 32 Year 2000 Decatur Fluorochemical Medical Surveillance Program Arithmetic Mean, Range, Geometric Mean and 95% Confidence Interval of Geometric Mean of Serum Fluorochemical Levels (ppm) by Type of Maintenance Job Maintenance Job Category Day Mechanic (N=ll) Day Electrician (N -8) Shift Mechanic (N = 3) Shift Electrician (N = 3) Arith. Mean Range G. Mean 95% C.I. Arith. Mean Range G. Mean 95% C.I. Arith. Mean Range G. Mean 95% C.I. Arith. Mean Range G. Mean 95% C.I. PFOS PFOA PFHS PFOSAA M570 PFOSA M556 2.16 2.14 0.32 0.49 -10.06 0.42-4.03 0.04-1.05 0.12 0.02 - 0.39 0.41 0.08 - 0.94 0.006 0.0005-0.02 0.02 0.02-0.36 1.41 1.76 0.19 0.08 0.84-2.37 1.13-2.73 0.10-0.36 0.001-0.14 0.29 0.17-0.50 0.002 0.001 -0.006 0.10 0.05-0.19 1.05 1.03 0.17 0.50-1.82 0.42-1.86 0.06-0.34 0.04 0.02-0.07 0.18 0.002 0.06 0.05-0.34 0.0005-0.003 0.01-0.12 0.95 0.93 0.14 0.4 0.16 0.005 0.05 0.68-1.34 0.66-1.32 0.09-0.22 0.0008 - 0.06 0.10-0.25 0.0006 - 0.002 0.03-0.08 2.37 2.52 0.42 0.96-3.72 1.03-3.42 0.13-0.58 0.07 0.05-0.11 0.38 0.30-0.48 0.006 0.002-0.01 0.11 0.06-0.15 2.05 2.22 0.35 0.07 0.38 0.92-4.58 1.03-4.79 0.13-0.93 0.003 - 0.11 0.29-0.50 0.005 0.002-0.13 0.10 0.06-0.18 1.21 1.04 0.25 0.04 0.98-1.49 0.73-1.33 0.09-0.37 0.03-0.05 0.19 0.001 0.08 0.17-0.20 0.0005 - 0.002 0.007 - 0.09 1.19 1.01 0.21 0.04 0.19 0.001 0.08 0.94-1.52 0.71-1.43 0.09-0.50 0.0007-0.06 0.17-0.21 0.0004-0.002 0.06-0.09 APPENDIX A BACK TO MAIN 3M Company Page 27 of 32 BACK TO MAIN 3M Company Page 28 of 32 D E C A TU R SU PPLEM EN TA L Q U E S TIO N N A IR E Thank you for participating in these exams. Please respond to each question with either a short answer or an `x' in the appropriate box. Last N am e________________________ First N am e________________________ Ml Employee Num ber_____________________ 1. W hat is your current job title?_______________________________________________ 2. What year did you start working in your current jo b ? ___________________________ 3. Please indicate in which area(s) you work in your current job. Mark an `x' in all boxes that apply. Building 1 Buildings 2 and/or 49 Building 3 (OSCL/OSF area) Building 3 (besides OSCL/OSF area) Building 4 North Building 4 (expander/dryer) Building 17 Buildings 38 and/or 51 Building 42 (packaging FC inerts) Building 61 (millroom) Building 61 (expander/dryer) Film plant (all buildings) Wastewater treatment plant (Buildings 36 and 57) Other. Please specify_________________________ If you currently work in Building 3 or 4, or you are a maintenance worker please proceed to questions 4 and 5. If you do not currently work in Building 3 or 4, and you are not a Maintenance worker your supplemental questionnaire is complete. 4. If you currently work in Building 3 or 4, on a routine basis, what is your team name? Answer only if you work in Building 3 or 4. Building 3 Alcohol Monomer Team Cell Feed Scotchban Scotchguard Lightwater Other Building 4 Inerts (work in specific areas of 3 & 4) FC Dyneon Other BACK TO MAIN 5. For Maintenance Workers only 3M Company Page 29 of 32 a. Please check the appropriate box that best describes your job: Day Mechanic Day Electrician Shift Mechanic Shift Electrician O ther:_____________________________________________ b. For Day Mechanics and Day Electricians only: If you are a Day Mechanic or Day Electrician, please indicate which building area you work in: Bldg. 2/49 Bldg 3 East Bldg 4 West Bldg 17 Bldg 4 North, 38, 51 Bldg 17 Bldg 4 North, 38, 51 Bldg 4 South, 61, wastewater, riverwater pump house HVAC Other: (please specify)___________ ;_____________________ __________ Appendix B BACK TO MAIN 3M Company Page 30 of 32 BACK TO MAIN Table Geometric mean, 95% confidence interval and range of fluorochemical levels (ppm) by current job categories among the 3M Company 1998 random sample (N = 126) of chemical employees Page 31 of 32 PFOS G. Mean 95% Cl. Range PFOA G. Mean 95% CL Range PFHS G. Mean 95% C.I. Range PFOSAA G. Mean 95% Cl. Range PFOSA G. Mean 95% Cl. Range M570 G. Mean 95% CL Range Cell Chemical Operator8 Operator*' (N = 5)________ (N ~ 47) Engineer/ Mill Labc Maintenance11 Operator* (N = 23)_________ (N = 11)________ (N = 13) Secretary* (N = 4) Supervisor/ Mgmtg (N = 18) Waste Operator*1 (N -5) 1.970*-*-* 0.732-5.304 0.325-6.840 1.481c- ^ h 1.250-1.755 0.471-7.260 0 39ia>bAg>h 0.256-0.597 0.095-1.740 1.299*'-* 0.822-2.054 0.2914.060 0.5898'b,d'h 0.419-0.828 0.230-2.040 0.397a,b,d,h 0.195-0.807 0.220-1.140 0.885* 0.480-1.630 0.091-10.600 1.504*-*"* 0.493 - 4.589 0.254-7.880 1.428c,f 0.422-4.833 0.126-3.64 1.887*>Sg 1.573 - 2.265 0.150-6.760 0.208a,b,d,*-t&h 0.134-0.324 0.035-2.320 1.095'f 0.670 -1.791 0.2114.680 1.2660,ig 0.985 -1.629 0.450-2.340 0 i72a>b'dA&h 0.113-0.260 0.095-2.611 0.631b-c-e-c 0.310-1.308 0.0214.540 1.542*^ 1.052-2.259 0.936-2.710 0.6971<utg 0.228-2.130 0.083-1.880 0.308-*-* 0.246-0.386 0.071-1.860 0.0788-b>g'h 0.046-0.134 0.005-0.905 0.1538 0.084-0.280 0.023-0.7^0 0.0748'b* h 0.047-0.116 0.028-0.374 0.0668>b,g 0.031-0.140 0.027-0.172 0.215*-*-* 0.115-0.402 0.010-1.420 0.232*-* 0.069 - 0.775 0.038-1.210 0003b'4* 0.001-0.009 0.001-0.016 0.0118-0-* 0.007 - 0.018 0.001-0.269 0.005bA* 0.003-0.010 0.001-0.073 o.on8-*-* 0.007-0.043 0.001-0.083 0.015s-*-* 0.010-0.024 0.004-0.038 0.002b,d>* 0.001-0.003 0.001-0.004 0.006 0.003-0.010 0.001-0.054 0.006 0.003 - 0.013 0.003-0.017 0.002b'* 0.001-0.005 0.001-0.011 0.0288Ad-g 0.017-0.048 0.001-0.487 0.005b, 0.002-0.010 0.001-0.063 0.009b 0.003 - 0.025 0.001-0.569 0.0268-* 0.016-0.040 0.012-0.204 0.021 0.009-0.054 0.009-0.080 0.007b 0.003-0.020 0.001-0.612 0.012 0.003-0.048 0.002-0.161 0.033b,d 0.024 - 0.045 0.024-0.056 0.131a>o,e,f'g 0.094 - 0.182 0.009-0.992 0.049b'd 0.034-0.071 0.008-0.410 0.2048-'*'tg 0.124-0.335 0.038-0.701 0.042b,d 0.034-0.051 0.025-0.115 0.030b,d 0.013-0.071 0.010-0.072 0.064b>d 0.037-0.111 0.010-0.553 0.079 0.052 - 0.121 0.050-0.159 Table (continued) M556 G. Mean 95% C.I. Range 0.011b-d 0.005 - 0.218 \ 0.003-0.028 0.044a'CAtg 0.032 - 0.061 0.001-0.380 0.010b'd 0.006 - 0.015 0.002-0.127 (a-h) p < 0.5 comparison for eachjob category BACK TO MAIN 3M Company Page 32 of 32 0.074a'CAt'g 0.041-0.135 0.016-0.406 0.009b,d 0.006-0.015 0.002-0.045 0 . 0 10b'd 0.003-0.031 0.003-0.030 0.015b,d 0.007-0.030 0.003-0.336 0.027 0.011-0.068 0.013-0.157