Ipww.w.u--- ----------------------------------------- '-- -- -- -- -- -- -- -- ;---------------------------------- U 2 2 6, WZ/ 469 DuPont-11418 MAA- $27 TRADE SECRET Study Title H-25425: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 2 of 5 Laboratory Project ID: DuPont-11418 Test Guidelines: U.S.

AR226-3360 > ATMOMSPEHCAEHLRACINCOISHLMOIFSLESOTFCIMnFFEL2SnU+1OACNRHDO2CTDHEE2LGOORHMAEDRATION Valrie Bossoutrot*, Tanya Kelly#, Isabelle Magneron*, Wahid Mellouki*, Howard Sidebottom#, Klaus Wirtz and Georges Le Bras* * LaCbe*onrCtarthooeidmreeiEsdtsertyuCdDoimeopsbaAurtsmmtiboeinnetn,ettUaSlneyisvstedremslietMyseRCdoiatlelcertrgifesn,,eDCou,NbVRliaSnleO(nIcRrliLaa)(nSsP()F) SETAC Prague 18-22 April 2004 Context : Long chain perfluorinated carboxylic acids (PFCAs, CnF2n+1C(0)0H, n = 6-12) oPbFseCrAvesd:innfoisthgaenndermaallmymusaelsd directly in consumer or industrial m- parteesruimalasbly degradation products of precursor chemicals : potentially FTOHs Fluorotelomer alcohols (FTOHs, CnF2n+1CH2CH2OH) : --UPsreosd:uicnttieornm: e5dxi1a0te6skignymra1n(u(82f0a0%c%tupnroeolynomfpdoeirlvyicemraseperpipclricoadtuiocntss)) -- AOtbmseorsvpehdeirnicthsoeuartcmesos:pdheegrread(uaptioton 1o35poplgymnre3r) and non polymeric materials - EthxapteicntceodrtpoorpaatretiFtiToOn Hinsto(?

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P-1 i L s r research foundation International Life Sciences Institute Document Processing Center (Mail Code 7407M), Room 6428 Office of Pollution Prevention and Toxics U.S.

ty Proven Results.

ftR A & 6 - 0 7 4 8 READY BIODEGRADATION (OECD 301E) TEST SUBSTANCE________________________________________________ Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-203CE. (1Octanesulfonic acid) (CAS # 2795-39-3).

A C U T E T O X IC IT Y T O F ISH (FA T H EA D M IN N O W ) T E S T S U B S T A N C E __________________________________________________ Identity: Mixture containing perfluorooctanesulfonate which m ay also be referred to a s P F O S , FC-95, or a s a component of FC-3003. (1Octanesulfonic acid) (C A S # 2795-39-3).

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RECEIVED 0PPT NCIC 2003 JUL -7 HM.-00 Telomer Research Program MfSfm wmmmm Ciarlarti Report Title: 8-2 Telomer B Alcohol: Acute Oral Toxicity - Fixed Dose Method Author(s): Carol Finlay CEnovnitrroancmtoern:talES.Ic.iednucPeso,nNt edwe aNrekm, DouelraswaanrdeCo., Flaskell Laboratory for Health and Study DCIInnaoitLtmeiaispf:teilo:entiA:onpA:riplSr2iel5p2,t,e2m2000b01e1r- 1M7,a2y00117, 2001 bSytuodryalOgbavjeacgteivteo:mTaoleaasnsedsfsetmhealaecruattes.oral toxicity of 8-2 Telomer B Alcohol when administered wmroiMnebegotasrirueagttlergahavrlatrie,istadiytmnrlsiteaecevnalrtiidnvendaddtesluinsaMgbcnnpaedesotitososohtfun-fodosdrtporeosgess:aanpinndogSgenroidonsareugnitpnlidwess0oweou.rfr5eeea5r%ledmfdaasaamosaqdtscaueeergdesidfeoimaoucoifselary2dlmed0toyh0eansrt0nhfodpuymuonlg5gschcttf-eoi8adolu-slno2utte.sltTidohnseefgeleo,smdtmwuaaydeelyrer1e.Br6aaRtaAdsnam.ltdcsiOonewhixbsoeastlreem/errkveigwndaeetbibdiyogynghbsreooddfsoysarlty for sFiignndsinogfst:oxNicoitydewatehrse osececnu.rreNdo(gmroosrtsallietsyi/onnusmwbeerretrseeaetnedu:pmonalpeasth0o/5l;ogfeymeavlaelsua0t/i5o)n. .

From: B fW 4 J R*41y on 01/20/2002 09 22 AM To: ASNppQonvirorcorp com, rhamsigenvironccrp :cm cc: M Ann Sradly/STB/DUP@OUP *ohn R 8owman/AE/DuPont@QuPont Subjsct: 10 ug/L m Environ Hazard Narrativa ------------------------- Fcrvrarded oy Barnard j RetiiyiAE/CuPcni on 01/20/2002 09 23 A M ---------- From: Bernard J Reilly on 01/20/2002 09 2i AM To cc: Subject: Gerald L Kennedy/AE/DuPont@DoPont Robert W Rickard/AE/DuPont@OuPont David M Rurak/AE/DuPontjgDuPont, M Ann 8raaley/S"rB/0UP@0UP, John R Bowman/AE/DuPontOuPont.

GLP10-01-02.