AttX-03%3 ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity: athPoceeinadrfse,luic1Poo,Fr1soD,ad2Sfe,l2u,c,oaF3rn,Co3e--,s,14u2a,4l0mf,o,5mno,5aor,tn36eiM,,u6am,7Sm,as7mma,8oitp,,n8leiC,u9AmJ,29S9,s1#0a05lt6,;-171m09.

CO RN ING Hazleton MUTAGENICITY TEST WITH T-6564 IN THE SALMONELLA - ESCHERICHIA COI//MAMMALIAN-MICROSOME REVERSE MUTATION ASSAY WITH A CONFIRMATORY ASSAY FINAL REPORT AUTHOR Timothy E.

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( \ m r O M lj BIODEGRADATION (BOD) TEST SUBSTANCE Identity: Perfluorooctanoic acid; may also be referred to as PFOA, FC- 26, or FX-1001.

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (E.G..DAPHNIA) TEST SUBSTANCE Identity: Perfluorooctanoic add; may also be referred to as PFOA, FC26, or FX-1001.

' CAS Number 31506-32-8 3M Company AfLAaeJ^I Voluntary Use and Exposure Information Profile N-Methyl perfluorooctanesulfonamide I.

3M Specialty Materials June 28, 2000 c f yr - - 13M Center S65t.1P7a3u3l, M11N0055144-1000 0300 M 22.6- 062% r&(-5s>, m-o ---aonmmo ---F3aCo coom VIA EXPRESS MAIL Dr.

M 0802s ACTIVATED SLUDGE RESPIRATION INHIBITION TEST TEST SUBSTANCE____________________________________________ Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-206C and L-5439. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The 3M production lot number was 501.

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OS-8 VW 00$09^08B(t) 19:07 ftft 000112022603163 I l D I C K A N S A I R & D IRD P01/01 -AH 2.2.6. 0 3 5 Dmnippon Ink & Chemicals, Inc.

b4> NOTE TO FILE - OPPTS 50639 October 23, 2000 FROM: Karen Lannon SUBJECT: Revised PFOS Hazard Assessment M S A 6 _ 03lf-& Attached is a revised PFOS Hazard Assessment.

3M Specialty Materials Igfff December 20, 2001 3M Center St.

M-2 _ />.5T To: NCIC OPPT/DC/USEPA/US@EPA cc: Subject: AR226: Comments on Telomer Research Plan As indicated below, please include the attached email correspondence from Rich Purdy to Charles Auer in the file for AR-226.

uaS" Estrous Cycling and Natural Delivery/Litter Observation Data FI Estrous Cycling Data, From Data Analysis Presented at EPA on August 30,2002" APFO Dose Group (mg/kg/day) 0 1 3 10 30 All 4-Day 14/30 19/29 9/30 15/29 15/30 Cycles 3-5 Day Cycles 24/30 26/29 21/30 25/29 27/30 Cycle Length (Days) 2 3 4 5 6 7 8 Mean Cycle Length (Days) S.D. 1 2 75 18 5 1 2 4.3 0.8 Incidence of Cycle Length Per Group 0 1 80 16 2 1 0 4.2 0.5 5 7 57 32 5 0 1 4.3 0.9 2 5 84 14 3 0 0 4.1 0.6 5 5 86 17 0 0 2 4.1 0.8 > 4 Days Diest. > 3 Days Est. > 4 Days Diest. > 3 Days Est. 2 17 5 25 Aberrant Cycles * Parental 11 13 15 FI 33 25 29 4 16 5 11 P E M D End in Estrous Distribution of Cycle Status at Start of 21-Day Evaluation Period, FI 14 12 8 10 11 14 62 2 0 15 13 16 13 Distribution Rats in Estrous at End of 21-Day Evaluation Period, FI 13 17 18 19 1 13 3 14 5 11 2 12 19 hO C-i; P '0 CD C--~5I I ro 2?

t o _ I/ Oscar Hernandez 09/27/02 02:32 PM To: Vanessa Vu/DC/USEPA/US@EPA cc: Robert Flaak/DC/USEPA/US@EPA, Charles Auer/DC/USEPA/US@EPA, Margaret Schnelder/DC/USEPA/US@EPA, Seed.Jennifer@EPAMAIL.EPA.GOV@EPA, Barbara Leczynski/DC/USEPA/US@EPA, Priscilla Flattery, Robert Perlis/DC/USEPA/US@EPA Subject: SAB request Vanessa, attached is a request for an SAB review of a preliminary risk assessment of Perfluorooctanoic acid (PFOA).