Document 9w3GdgpqRq1NqkBvywEYnaDe

AR226-3075 snidv Title Inhalation Toxicity Screen wi rf hnrtflP> Project.1C HL-1997-00600 Author David P. Kelly ftf-.idv C o m p l e t e d July 11. 1997 performing Laboratory E. I. du Pont de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine Elkton Road, P. 0. Box 50 Newark, Delaware 19714 Page 1 of 2 Company Sanitized. Does no! contain TSCACBI Du Pont HL-1997-00600 TnViaiatiori Tnr<riev Srrppin with ! H-22485 inhalation toxicity sera. o c r f . " " `^ 0 5 ^ . ' ^ atmosphere was analyzed by rav iiters were immediately weighed to filter samples were collecte* ' Ater overnight drying in a determine the wetf . ^ ros ^ ^ e weighed to determine the dry aerosol desiccator, the filter samp _tr-tion8 during the four-hour exposure were weight. The mean aerosol ^ e n t r a t i ^ ,, ,, median aerodynamic 330 mg/m3 (wet) and 300 mg/m (dry) exposure rats showed a diminished diameter was 2.5 pm. At the en alerting response. No deaths Purina the exposure, however all rats the chamber, died within three j o a e d to H-22485 were red discharge from clinical signs observed in the r **P six rats died on the day of the eyes and red discharge from the nose. Tw remaining rat died two exposure, three rats died on y s showed severe weight loss days after exposure. The ^a C t h "t during the recovery period included o v th a t period. e p i c a l " ^ r^ TM n . * i o n . E x p .r iw n t.1 d e t a i l , o i lethargy, hunched posture, and irreguijyesp the study are in laboratory n o t e b o o t ^ ^ ^ * riinrnrtr r i r ........ rh"mhftr f t TM P hegft" rhnn)hfy *eroSQl Mean Cgnc. SD Range (rag/mJ ) 300 (dry) 91 180 - 490 Pnrrf-Y. fiig* AnfllYBi* MMAD GSD %<lpm %<3pm %<10pm 2.5 2.3 14 60 95 Mortality Deaths/Exposed 6/6 Work by 1 , l\ /` t X M. A. Pulliam, B.S. Toxicology Technician Study Director Kelly, B.S. Researcb^pSxicologist inhalation aniTCellular Toxicology a MMAD = Mass Median Aerodynamic Diameter(pm) b GSD = Geometric Standard Deviation Company Sanitized. Does not contain TSCA CPf