Document 7RkpdKjqmeRzmboLzjv09ENej
i\
AR226-2879 mmf Copies to:
E. I. du Pont de Nemours and Company Haskell^Laboratory for Toxicology and Industrial Medicine
HASKELL; LABORATORY REPORT NO
Material Tested ----------
HasNkoe. l1
12,943
Other Codes
Sample Ready For Testing
3/13/79
Material Submitted by
^Chemicals, Dyes and Pigments Department, Jackaor Laboratory
ORAL LD50 TEST
Procedure: The test material, as an Aqueous S d t ; % s r f . c " ftcre" '
. - . u * --
a 14-day recovery - * * tha " hd f d - j '
Results :
Dose
Average Body
(ng/fcg>- wexxnt ta;
6,000
257
Solution . W -- --
50
Average !Dose (ml)
3.1
5,000 4,000
252 254
45 2.8 40 2.6
9/10 4/10 1/10
Clinical Sian.
LD50**
loUHl
Stained face, congestion, hematuria, stained and wet perineal area, salivation, chromodacryorrhea,
lethargy, stained body, gasping, diarrhea and moderate weight loss after dosing at 6,000 mg/kg.
5,043
Stained face, wet and stained perineal area, lethargy,
ataxia, chromodacryorrhea, diarrhea, alPcift moderate weight lose after dosing at 5,000 mg/kg.
Congestion, lethargy, stained face, wet
8ti"J*ed
perineal area, chromodacryorrhea, MUwatiMi, atmiaad
nose and mild weight loss after dosing at 4,000 mg/kg.
Company Sanitized. Does not contain T S C A C i
- 2-
Stflaurv:
very low toxicity when administered orally to young adult ChR-CD male rata in single dosea; its
Ld SITu STOSS'mg/kg of body weight. Moat frequently observed clinical signs at most levelB included stained face, stained
and wet perineal area, lethargy, chromodacryorrhea, salivation, congestion, diarrhea, and hematuria. Stained body and
gasping waa observed at the 6,000 mg/kg level only. All levels had mild to moderate Initial weight loss followed by
sporadic losses through the 8th day and then followed by normal weight gain.
** 9SZ Confidence Limits: Lower: Upper:
Slope:
4,535 mg/kg 5,610 mg/kg
14L5
+ Finney, D. J., Probit Analysis. 3rd Ed., 1971, Cambridge University Press.
Report by:
Robert L. Trlvits Technician
RLT :scg Report No. 325-79 ^ D t a Issued; August
Approved by:
Ah Y. faw asfr
Gerald L. Kennedy Chief, Acute Investigations Section
Company Sanitized, Does not contain T S C C3J
