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REPORT EVALUATION OF THE MUTAGENIC ACTIVITY OF T-5869 IN AN IN VITRO MAMMALIAN CELL GENE MUTATION TEST WITH L5178Y MOUSE LYMPHOMA CELLS (WITH INDEPENDENT REPEAT) NOTOX Project 115954 NOTOX Substance 38196 - page 1 of 22 - 005631 RECEIVED m \!

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-^ 226-/607 From Barnard J *% 0 tQOOfcOOl 08:19 AM To rwily_bemfeOhemwl.oom cc rmratHy Q 6H > r*c nat aaipaCtthafoliogroup com. ]matzvHrningtontrutcorn Subject Oct 20 Hi Bern, Foggy beginning of the day here, but pretty good weather predicted, mom and I going to Lancashire later today for dinner, Joe's folks coming down, I am sure we can find some project to chip away at. certain I need to shorten the hot water line to the sink and midbath, could be easy or a bitch depending on luck.

Proven Results

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AR226-2105 *gsn TestResults Sam ple Date R ange Concentration Range Action Level Industrial Hygiene 1/1/78 12/31/78 100% Sam ple Dt Sam p le # Duration Type Em ployee Name BTO: 08 TEFLON LO G : 701 PIN E P O W D ER D R Y ER -EA ST S ID E #2 2/16/78 62673 Z Pern Chem ical C -8 BTO 5 08 LOO: 702 TEFLON FIN E P O W D ER D R Y ER C O N T RO L R O O M (A LSO S E E TTF031 2/16/78 S7139 Z C -8 BTO: 08 TEFLON L O C : 703 FIN E P O W D ER PA CKO U T R O O M 2/16/78 49591 Z C -8 BTO: 08 TEFLON L O C : 704 A /S* F IN E P O W D E R C-8 W EIG H HOOD 2/16/78 51170 Z C -8 BTO : 18 TEFLO N CO PO LYM ERS L O C : 211 FEP-W ET FIN ISH IN G RO O M 7/24/78 59641 Z C -8 BTO : 18 TEFLO N CO PO LYM ERS L O C : 230 FEP-TRAYOUT 7/24/78 58603 Z C -8 J& .ili*# Cone Unit Percent <0.1 P P M 0.0% <0.1 PPM 0.0% <0.1 PPM 0.0% <0.1 PPM 00% <0.05 PPM 0.0% <0.05 PPM 0.0% AJP004113 Tuesday, January 16,2Q112:47:04 PM Page 1 of 1 EID113248

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P 1R A 6 - 3 3 / ^ 494 TRANSLATION SUMMARY OF BIOCONCENTRATION STUDY REPORT 1.

AR226-3339 Roy S Thompson Ilaria Colombo Watze de W olf (AstraZeneca, Brsxham, UK) (Solvay Solexis, Bolteie, Italy) (DuPont, Mechelen, Belgians) David G Farrar Robert A Hoke Jacques L'Haridon for:(ineos Chlor, Runcorn, UK) (DaPant, Newark, DE, USA) (CIT, Evreux, France) APME (Association ofPlastics Manmcterera in Earops) d-Hoc APFO Eavimaffisatsl Woridag Group _____________ _____ A p ME / Acute & Cfer@icCAoqunatetinctToxicity of APFO Background Physico-chemical properties of APFO Acute toxicity Chronic toxicity Risk assessment Potential role of ammonium ion in APFO toxicity Conclusions Acknowledgements AJpME 1 ArairAtucfutitielii&iitiCphtrrollniiic Arquacttic Tsio#xaitcit-yBoaf AckPgFrOtjiiiid Most commonly used salt o f perfluorooctanoic acid (PFOA) Essential processing aid in fluoropolymer and fluoroelastomer production (e.g.