AR 1%-oiGi REPORT AMENDMENT NO. 1 TWO YEAR ORAL (DIET) TOXICITY/CARCINOGENICITY STUDY OF FLUOROCHEMICAL FM-3924 IN RATS Experiment NO.0281CR0012 The attached pages include revisions in the first paragraph on page 3 of the Summary and in the third paragraph of page 22 of the Discussion.

X flcaranun 7-1V A TECHNICAL REPORT SUMMARY "&/1 6 /7 8 TO: TECHNICAL COMMUNICATIONS CENTER 201-2CN .im p o rta n t - if report is printed on both sides o f paper, send two copies to T C C J D,U,S,rRT, - Analytical and Properties Research Laboratory O ept.

DISSOLVED OXYGEN CONTRAII ON - mg/1 BACK TO MAIN Z ra< < a a3 a* u u- Z 1NU3J J avn z TIME - minutos BACK TO MAIN 3M E n v ir o n m e n t a l L a b o r a t o r y A cu te T o x i c i t y o f a Compound (S u b s ta n c e ) t o - A c t i v a t e d S ludge, M ixed U g jja r P r o t o c o l R e f e r e n c e : EAR 11 / 8 / ?

3M Environmental Laboratory AR116- ooz^ k) M ethod Analysis of Potassium Perfluorooctanesulfonate or O ther Fluorochemical Compounds in Urine E xtracts U sing H PL C -E lectrospray/M ass Spectrometry/M ass Spectrom etry Method Number: ETS-8-97.0 Adoption Date: Author: Lisa Clemen, Robert Wynne, Glenn Langenburg Revision Date: Approved By: Laboratory Manager Group Leader ------ _ 7 / u /y 5 Date f/Z-37# Date - A C iu m -____________________ ______________________ Technical Reviewer Date 1.0 Scope and Application_________________________________________________ 1.1 Scope: This method describes the analysis of urine extracts for fluorochemicals using HPLC-electrospray/mass spectrometry. 1.2 Applicable Compounds: Fluorochemicals or other ionizable compounds. 1.3 Matrices: Human, rat, and monkey urine, or other fluids as designated in the validation report.

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AR AG _ TSCA NCIC Notification Form for CBI Documents Docket Number: _______ftR J 2& _______________ Document Control Number: (fC?

310 Form -8747-11-A TECHNICAL REPORT SUMMARY TO: TECH N ICA L COMMUNICATIONS CEN TER - 201-2CN (Im portant -- I f report Is printed on both sides o f paper, send two copies to TC C .i Olvition .

Item 10: Monitoring - Fluoropolymers EPA Data Needs: (Draft 9-21-03) Data Need LOl Commitment MRealenausfeascturing Dwaastateownatreerl,ealasnesdftiollaliera,cwhaatteer, Irwamlffneariaraolnfca,eosmdinatwlrfeuismitwafelilaetaaeocstltrietfeo,uaPrnrc,iFhnoOagntAe to Creolenatisneused monitoring of MSitaensufacturing Concentration of 'PslgbmfauaFrinoraocOfdntiuaalfAunic,itfdleiwlaeiwcnwslaetasuaaattiterecreirw,hnr,,agasttoeeirla,,t wScmouaanrsnfctaueecwfneatacrwtateutarirto,iennlrags,ngsadirtftoeiluslnldewacahtaetre, Limited biota data Modeling ofPFOA in air AnededdistiboenyaolnddatLaOl EPA Proposal to Address Data Needs Manufacturing none McPaodFondOncitAieitonontirrneaadlatiibori,nosstoaoilf, Scocnreceennitnragtiloenvealnmdoenxitteonrting ofPFOA in air to quantify Samqcaurneauetifncaincstgpuerlceinivegesl,fmapcloialnnitititseo,srhinegrboivfoPrFesO,Aaviinanb,iotetrare(esgtr,iafilsshpaencideso)thaetr AR226-2340 EXP000011 - 1- EXP000012 r~~ Item 10: Monitoring - Fluoropolymers EPA Data Needs: (Draft 9-21-03) Data Need MOfafnSuitfeacftruorming CPsgagmfuaFnrororcaadOnfuindaclAbnuiiceetidfenionaiewtntwtcsraaatfaaurttditeiorreooirm,rnw,n,gsnoofil, LOI Commitment Anededdistiboenyaol nddatLaOI PsgmuFraorOfnuauAncfdeacwcwotanuatcrteeiernrnfgtarronsamidttieosns in McPaodFondOncitiAeitnootnirrneaadltaibiori,nosstoaoilf, Limited biota data Modelingofair contamination EPA Proposal to Address Data Needs Monitoring of PFOA in air to quantify concentration and extent ofoffsite contamination AWabtedoadcdriokdtilsiol,teintcooatnleqadgulrtaoomnutdaniefndytuwefPraamFtceOtirunAremintoihgnneisgteiortxoertisuen.nngdGt,wasrnioamdtuenilrledaovwrfeftaleotroetWerf ccaoosnhntitanamgmtiomnnaattiioonn apytoB iJesite...^........

AR226-3387 A 90-Day Gavage Study with One-Generation Reproduction Evaluations in Rats with a Fluoroalkylethanol Mixture E.

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f\RM >-o\G\ SUMMARY OF THE EFFECTS OF PFC's ON MITOCHONDRIAL BIOENERGETICS IN VITRO The attached diagram describes the metabolic relationship for the various PFC's that were selected for inclusion in this study.

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f o r m 8 7 4 7 -1 1-A ORIGINAL TECHNICAL REPORT SUMMARY TO: T E C H N IC A L C O M M U N IC A T IO N S CEN TER - 201-2CN ,im portant -- If report is prin ted on both sides o f paper, send two copies to T C C J O ivision CRL - Analytical and Properties Research Laboratory Project Trace Fluorochemicals in the Environment R eport Titla ~* -- IRDC 137-092: FC-95/Monkey To J.