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CH-2 ESTABLISHED1802 E.

APPROXIMATE COSTS FOR TWO-YEAR INHALATION TOXICITY STUDIES ON Ti02 AND TiCl4 (18 Month Exposure - 6 Month Holding Period) Animals Initial Cost Maintenance 1700 rats x $2.10/rat 1680 rats x 0.08/day x 730 days (Total excludes rats sacrificed during study

SERIAL NUMBER | FILING DATE | ()"' 6H OIAO UNITED STATES DEPARTMENT OF COMMERCE Patent and Trademark Office Address COMMISSIONER OF PATENTS AND TRADEMARKS Washington. 0 C 20231 FIRST NAMED APPLICANT | ATTORNEY DOCKET NO.

Telephones: (5)533-50-60 (5)207-13-64 (5)207-01-56 (5)208-74-70 (5)208-78-87 (5)208-79-75 IHTHOFF, GOMEZ VEGA & UHTHOFF, S.C.