More recent observations have shown that this is not the case at all for some of the other organic lead compounds, and that it is probably not the case for tetraethyl lead.

P* Hugo General Superintendent Associated Oil Company Avon, California Dear Mr* Hugo:- Your letter of September 5feh concerning an employee of yours who has been diagnosed as having progressive muscular atrophy, has been referred to me from the Hew York office of the Ethyl Gasoline Corpora tion* As a result of years of experience with the conditions in testing laboratories, it seems almost certain that there is little or no opportunity for significant lead exposure in work of this type* Therefore, unless the occupation of your employee differs materially from that of a large number of other men who have been engaged in this work, there is no basis in his occupational exposure for considering seriously lead as a cause of his present Illness* Progressive muscular atrophy is a clinical condition which has been known for some time and there is no good reason for assuming the presence of such a factor as lead in the origin of the condition* It must be admitted that we do not know very much about the precise background of ita occurrence* It Is also true that lead poisoning is likely to result In muscular damage and in atrophy of certain groups of muscles* In the case of lead, the picture is usually quite characteris tic and it should be possible to make a differential diagnosis* We shall be very glad to do what; we can to establish a diagnosis In the case of this man* One of my associates will be in California in the course of a regular trip for the purpose of examining the personnel at the mixing plants* I shall turn your letter over to him and he will be glad to make an examination and obtain as much clinical information as is possible* In the mean time we should be glad to make analyses on the blood and excreta of your employee in order to see whether he shows any evidence at present of lead absorption* It may or may not be wise to do this at present slnoe it may be that his exposure was discontinued some months ago, in which Mr* Y?

Assuming that a tube of tooth paste contains about 75 grams of material with a concentration of 200 p.p.m. of lead, and as suming that one uses about 2 grams of the tooth paste per day, the amount of lead taken into the mouth would be Q.lf milli grams of lead.

I was most interested in your thought that the absorption of lead from the intestine may be accelerated in the lead-intoxi cated patient.

Wilson reported that a comparison received from Mew fork giving the standing of the various branches of the National Lead Company as of Hay 1, 19kl on sales of regular paste white*lead and also on the new white-lead paint, showed the following!

Siebert: I have been checking the records in the lead cases which we have tried and also the reports of the courts of last resort throughout the country on lead appeals, and find that the latter, at least, are rather unanimously in support of your view that the best laboratory for lead tests is Kehoe.

There are certain things in his con dition however, which suggest that it may not be lead poisoning, and on account of these facts, plus the fact that we have no evi dence which would lead us to believe that he has had a significant exposure, I have not been able to arrive at a diagnosis of lead poisoning.

Lead driers are desirable in paints which do not contain lead as a basic component.

However, Du Pont firmly believes that under the conditions*of exposure studied, the findings do not provide substantive evidence that inorganic lead or lead alkyls cause neurobehavioral effects.

Mule Spinner, 426 Occupation, 393, 394, 426 Sex, 426 War Gases, 419 Latency Period, 754, 735 Age, 758 Anatomical Structure, 756, 757 Cancer Age, 754, 755 Detoxication of .Carcinogens, 757 Excretion of'Carcinogens, 736 Intensity of Exposure, 756 Potency of Carcinogen, 755 Relation to Life Span, 752 Lathe Worker, 156 See also Corkstone Worker Laundress, 301, 653 Lead, 577, 667, 716, 721 Erythrocytosis, 377 Liver Cirrhosis, 346 Lead Arsenate, 22 Lead Arsenate Manufacturer, 710 Lead Miner, 326, 313 Lead Ores, Smelting of, 33 Lead Smelter, 33, 710 Lead Worker, 34, 328 Leather, Arsenic in, 483 Leather, Artificial; Maker of, 479 Leather Worker, 29, 209 Lebanon, Cirrhosis of Liver, 353 Leiomyoma, 650 Uterine, Traumatic Cancerization of, 650 Leiomyosarcoma, 650 Lens Grinder, 163 Leukemia, 14, 16, 592 Benzol Poisoning, 395 Carcinosis with, 390 Causes of, 770 Correlation Hypothesis, 590 Drug Sensitivity, 591 Increase of, 593 Joachimsthal Chemist, 455 Infectious Diseases, 589 Osteosclerosis with, 590 Placental Filter, 620 Pregnancy in, 620 Radioactive Substances, 608 Relation to War Gas Poisoning, 621 Roentgen-rays, 608 Shift in Types, 593 Leukemia, Actinic, 607 See also Radium Leukemia, Roentgen-leu kemia Experimental, 611 Occupational, 607 age, 607, 608 causal relations, 609, 610 eosinophilia in, 609 incidence, 607, 610 medico-legal aspects, 612 occupation, 608 sex, 607, 608 types, 610 Therapeutic, 610 Leukemia, Benzol, 14 See also Benzol Leukemia Causal Relations, 597 Experimental, 398, 599 Incidence, 597 Occupation, 597 Sex, 597 Leukemia, Myeloblastic, Radium Poisoning, 6 07 Leukemia, Myeloid, 589 Leukemia, Traumatic, 613 Age Distribution, 619 Causal Significance of Trauma, 615 Classification, 616 Diagnosis of, 621 Location of Trauma, 614 Medico-legal Aspects, 619 Sex, 619 Symptoms, 617 Types of Trauma, 618 Leukemiogenic Agents, 626 Leukemoid Reactions, 589, 591, 597 Actinic, 604 Benzol, 394, 595 Roentgen-ray Exposure, 607 Leukoblastosis, 588, 592 Classification, 589 Occupation, 593 Leukoblastoma, 588, 592 Classification, 389 Occupation, 593 Leukocytosis, 589, 397 Actinic, 604 Benzol, 594 Leukoderma, 44, 766, 767 Dyes and Intermediates, 211 Solar Cancer, 239 Leuko-melanoderma, Roentgen-cancer, 258 Leukopenia, Actinic, 604, 607 Benzol, 594 Radioactive Substances, 602 Roentgen-rays, 602 Leukopenic Anemia, 676 Leukoplakia, 317 in Glass Blower, 320

There is no question about, some slight absorption of lead under these conditions .

I know nothing of the status of these, men with respect to their clinical condition or the nature or duration of their employment - However, it Is apparent from these results alone that no one of these men bar had any slgnific&Bt occupational exposure to lead* All of the results are within normal limits, being just like results that would be obtained if one. caxrled out analyses on the correspondlag materials from random individuals in the normal population of and professional people* I have a copy of Doctor .Kitmalllor* letter of November 29, and 2 wish to confirm his statement that I am heartily In favor of a comprehensive investigation of the status of your employees with respect- to occupational hazards* As Doctor- Kitsmiller lias stated, I expect to be in Miami during the Christmas period, a M if It is possible and is desirable on your part 1 should be very happy to discuss vlth you tho aocosaary details of %our work In tills . connection* If there are any specific matters that I should be prepared to discuss vith you, X should be glad to know of them at your convenience* I have just noticed that copies of the analytical reports of the material obtained from a wing tank of one of your company** jlano are available, and it seems best that these reports be forwarde& to you for appropriate handling* A notation has come to me today through one of the representatives of Ethyl Corporation that Mr* Morris of your company has been inquiring about these results and no doubt he will wish to be informed about them* It will be noted that the lead content of these samplo* is quite low* The concentration of tetraethyl lead is negligible while the total lead content as represented by that "extractable by acid** is so low as to have little significance from the point of view of hazard* Undoubtedly if a large quantity of scale and dust, containing such a concentration of lead were to be suspended in the atmosphere it could give rise to some hazard under conditions of prolonged exposure, but the risk of lead exposure from this source is certainly not very great* It appears that seme of your company*s employees have been apprehensive about their exposure to lead* K E nip'; Ut> #- KJ V/ U O Dr* Howard K.

HE 0009287 '(b) For use as a m otor fuel only CON TAIN S LEAD (Tetraethyl) N9999.01

It is also true that lead poisoning Is likely to result In muscular damage and In atrophy of certain groups of muscles.

Your Purpose Soft Paste White-Lead.