Doaerays re ont chan INSTRUCTIONS FOR STAFF WORKSHEET Contains a summary of available data and ongoing staff analysis Data and analysis are subject to change LBatst RAeevviiosnesd:: 55/23/0177 ReSuEvpapilmeamieonnotFOortiugsiendalonReKseiyewSt(ucdoimespldeteendtoend12n72U0S0E7P)A PPeerrfflluuoorrooooccttaannee SSuullffoonnaattee Supplement to Original Review (completed on 12/07/2007) Re-Evaluation Focused ~n Key Studies Identified in US EPA Health Effects Support Documents Released May 2016 Keer orginal ecw worksheet (ADASENILIACOMMON Guidance - Waters resins: Refer to original review worksheet (\\Data3fb\eh\HRA\CO3dMON\Guidance - WaterkTox reviewsComet FnPFOSFOS 200 Reew POS Foal Nov 7p) evsoped i 307 for completed\Final\PFOS\PFOS 2007Review\PFOS Final Nov 07.pdf) developed in 2007 for Fo additional intbrmation CCAASS ##ss 11776633--2233--11 ((aacciidd)) 2299008811--5566--99 ((mamnmmoonniiuumm ssaalltt)) 7700222255--1144--88 ((ddiieetthhaannoollaammiinnee ssaalltt)) 22779955--3399--33 ((ppoottaassssiiuumm ssaalltt)) 2299445577--7722--55 ((lliiththiuiumm ssaalltt)) ote: perlurooctarnoant doc ot av a pci CAS mumber [Note: perfluorooctanoate anion does not have a specific CAS number.]

CorporatOeccupationMaeldicine 3M CenterB,uildin2g20-3W-05 St.PaulM,N 55144-1000 65''1,34'2130Telephone 6517339066Fax 5.

SciFinder Initiating Search References: Ionic liquids Advanced Search: AND CAS Registry Number: Search Tasks 37181-39-8 = Triflate Anion Task Exported: Returned Reference Results (577) Search Type References Page 1 Task History September 19, 2023, 8:32AM View View Results Copyright 2023 American Chemical Society (ACS).

CECHA EUROPEAN CHEMICALS AGENCY Annex to the ANNEX XV RESTRICTION REPORT PROPOSAL4 FOR A RESTRICTION SUBSTANCE NAME(S): Per- and polyfluoroalkyl substances (PFASs) IUPAC NAME(S): n.a.

14 < S < 5 6 _ A H - O DRAFT REPORT DRY RUM CREEK WASHINGTON, WOOD COUNTY, WEST VIRGINIA NOVEMBER 1997 RECEIVED PPT NCC 23MAR3I AH10:21 PREPARED BY: M a r k D.

PPEERRFFLLUUOORROOCCAARRBBOONN ((PPFFCC))--CCOONNTTAAIINNIINNGG FFIIRREEFFIIGGHHTTIINNGG FFOOAAMMSS AANNDD TTHHEEIIRR UUSSEE IINN FFIIRREEFFIIGGHHTTIINNGG TTRRAAIINNIINNGG IINN MMIINNNNEESSOOTTAA DDEELLTTAA PPRROOJJEECCTT NNOO..

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Analysis of the most appropriate regulatory management options (RMOA) Substance Name: EC Number: CAS Number: Date: Poly- and perfluoroalkyl substances (PFAS) N/A N/A March 2023 ACKNOWLEDGEMENT This document was drafted in close partnership with the Environment Agency Page 1 of 192 DISCLAIMER With reference to the use of the information and data contained within this document, HSE, as the Agency for UK REACH makes the following disclaimer: The conclusions of this document have been compiled using information available at the time of writing.

FLUOROCARBONS AND HUMAN HEALTH: STUDIES IN AN OCCUPATIO NAL C O HO RT A TH ESIS SUBM ITTED TO TH E FACULTY O F TH E GRADUATE SCHOOL O F TH E UN IVER SITY O F M INNESOTA BY FRANK DAVIS GILLILAND IN PARTIAL FULFILLMENT O F TH E REQUIREM ENTS FOR THE DEGREE OF DO CTOR O F PHILOSOPHY/ENVIRO NM ENTAL HEALTH OCTOBER, 1992 3M MN03112178 ACKNOW LEDG EM ENTS I am indebted to Dr.

Analysis of the most appropriate regulatory management options (RMOA) Substance Name: EC Number: CAS Number: Date: Poly- and perfluoroalkyl substances (PFAS) N/A N/A March 2023 ACKNOWLEDGEMENT This document was drafted in close partnership with the Environment Agency Page 1 of 192 DISCLAIMER With reference to the use of the information and data contained within this document, HSE, as the Agency for UK REACH makes the following disclaimer: The conclusions of this document have been compiled using information available at the time of writing.

ELSEVIER Chemosphere 129 (2015) 33-38 Contents l ists available at ScienceDirect Chemosphere journal homepage: www.elsevier.com/locate/chemosphere Chemosphere Stockholm Arlanda Airport as a source of per- and polyfluoroalkyl substances to water, sediment and fish Lutz Ahrens a, Karin Norstrom b'*, Tomas Viktor b, Anna Palm Cousins b, Sarah Josefsson a Dept. of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), Box 7050, SE-750 07 Uppsala, Sweden b II/L Swedish Environmental Research Institute, BOX 21060, SE-100 31 Stockholm, Sweden 11) CrossMark ARTICLE INFO Article history: Received 19 December 2013 Received in revised form 18 March 2014 Accepted 22 March 2014 Available online 10 May 2014 Handling Editor: Klaus Kfimmerer Keywords: Per- and polyfluoroalkyl substances (PFASs) Perfluorooctane sulfonate (PFOS) Aqueous fire-fighting foams (AFFFs) Bioconcentration factor (BCF) Sediment/water partition coefficient (Kd) ABSTRACT Fire training facilities are potential sources of per- and polyfluoroalkyl substances (PFASs) to the nearby environment due to the usage of PFAS-containing aqueous fire-fighting foams (AFFFs).

Corporate Occupational Medicine 3M Center, Building 220-3W-05 St.

`IINCNoSnSTtTaRiRnUUsCCaTTsIIuOOmNNmSSarFFyOOoRRf aSSvTTaAAilFFaFFbleW WdOOaRtRaKKaSSnHHdEEoEnEgTToing staff analysis Data and Contains Data and analysisare subject to change a summary of available data and analysis are subject to change ongoing staff analysis Last Revised: 5/3/17 Last Revised: 5/3/17 PPeerrfflluuoorrooooccttaannooiicc AAcciidd Supplement to Original Review (completed on 12/07/2007) ReS-uEpvpalleumateinotntoFoOcruigseindaol nReKveiyewSt(ucdoimesplIedteendtiofnie1d2i/n07U/S20E07P)A Health Effects Support Re-Evaluation Focused on Health Effects Support Documents Released May Key Studies Identified in Documents Released May 2016 [IS EPA 2016 RRreeefferevttrooiooerriiggwiinnsaall-rreecFvviiioenewwamlwwpoPorFrlkkOssAehh\eetPeetFteO({Alldoo_cc2aa0ttee0dd7Raatte::v\Wi\DDeawat\taPa3Ff3bOM\eA\he~FHIiRRnaAAl\\CCNOoOvM M0V7M.IpOOdNNf)\GGuduieviddeaalnnoccpeeed-- iW Wnaat2t0ee0rr7i\TTfooo~xr `additional information reviews-completed\Final\PFOA\PFOA 2007Review\PFOA Final Nov07.pdf) developed in 2007 for additional information (CCAASS ## 333355--6677--11((ffrreeee aacciidd)) 5825-233633-551--66(66a--0m0m((oaaccniiidduffmlluusooarrliid,deeA))PFO) 3825-26-1 (ammonium salt, APFO) 335933 (slver sl) 22339955--0000-88 ((ppoottaassssiiuumm ssaalltt)) 333355.9-953--53((ssoidlvieurmssaallt)t) [Note: perfluorooctanoat3e3a5n-i9o5n-5do(essodnioutmhasavlet)a specific CAS number ] [Note: perfluorooctanoate anion does not have a specific CAS number.]

BACK TO MAIN 3M Medical Department Study: T-6395.14 Analytical Report: FACT TOX-111 LRN-U2994 Study Title Oral (Gavage) Pharmacokinetic Recovery Study of PFOS in Rats Analytical Laboratory Report Title Determination of the Concentration of Perfluorooctanesulfonate (PFOS) in the Serum, Liver, Urine, and Feces of Cri:CDBR VAF/Plus Rats Exposed to PFOS via Gavage Data Requirement Not Applicable Author 3M Environmental Laboratory Study Completion Date at signing Performing Laboratories Urine Analyses Feces Analyses 3M Environmental Laboratory Building 2-3E-09, 935 Bush Avenue St.

IBUTE DISTR Y OR COP T NO - DO ERIALS MAT YRIGHT COP GLOBAL INITIATIVE FOR CHRONIC OBSTRUCTIVE LUNG DISEASE GLOBAL STRATEGY FOR THE DIAGNOSIS, MANAGEMENT, AND PREVENTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2023 REPORT) UTE TRIB DIS Y OR COP T NO - DO ERIALS MAT YRIGHT COP 2022, 2023 Global Initiative for Chronic Obstructive Lung Disease, Inc. i GOLD BOARD OF DIRECTORS (2022) GOLD SCIENCE COMMITTEE* (2022) Alvar Agusti, MD, Chair Respiratory Institute Hospital Clinic, IDIBAPS Univ.