COVAH^ THE DEVELOPMENT SERVICES COMPANY Sponsors: APME Ad-Hoc APFO Toxicology Working Group FINAL REPORT Study Title: 26-Week Capsule Toxicity Study with Ammonium Perfluorooctanoate (APFO) in Cynomolgus Monkeys Author: Peter J.

COVAH^ THE DEVELOPMENT SERVICES COMPANY Sponsors: APME Ad-Hoc APFO Toxicology Working Group FINAL REPORT Study Title: 26-Week Capsule Toxicity Study with Ammonium Perfluorooctanoate (APFO) in Cynomolgus Monkeys Author: Peter J.

r Afszb - \h-l*h 000161 DRAFT REPORT DRY RUN CREEK WASHINGTON, WOOD COUNTY, WEST VIRGINIA NOVEMBER 1997 PREPARED BY: Mark D.

EEB European Environmental Bureau Brussels, 25.09.2023 2 nd EEB submission to the "universal PFAS REACH restriction" (uPFAS) This submission is the second contribution of the European Environmental Bureau (EEB) to the public consultation on the proposal for universal PFAS restrictions.

Environmental protection investigations initiated in the 1990s proved extreme environmental hazard of perfluorosur factants based on perfluorooctane carboxylates and perfluorooctanesulfonates including "branched" or "linear fragments" --C7F15COO_ and --C8F17S 0 3_ produced "electrochemically" or by "telomerization of tetrafluoroethylene", respectively.1'2 These substances are extremely stable in the environment, unhydrolyzable, and non-biodegradable, but they are actively bioaccumulated and migrate in the food chains.3''1 Major manufacturers of long-chain fluorocarbons (such as 3M, DuPont, Daikin, etc.) have ceased or cease the production and sale of fluorocarbons, replacing them with alternative shortchain substances.

Ad Sa 6 - N-Et FOSE alcohol Pharmacokinetic - / 0 0 0 3 oz Biotrreformation of '^C-N-Btbyl FOSE in Rats Aitar Administration in Feed for One Week .. 7 January 28, 1983 Conducted At: During: Conducted By: Report By: Reviewed By: Rlker Laboratories, Inc. 3M Center St.

The intemal standards used were a dual labeled PFOS where two '*0 molecules were included in the sulfonate group (intemal standard, >99% purity, synthesized by Research Triangle Institute, Research Triangle Park, NC) and a dual labeled PFOA molecule, where the carboxyl and alpha carbons were labeled with "C stable isotope (greater than 97%, provided by DuPont, Wilmington, DE).

EuDiCo GmbH European Directives Consultancy Reuschenberger StraBe 57 51379 Leverkusen Dr.

8 PP ANALYTICAL BIOCHEMISTRY 118, 336 343 (1981) AR226-1440 Characterization of Ftuorinated Metabolites by a Gas ChromatographicHelium Microwave Plasma Detector-- The Biotransformation of 1H, 1H,2/-/,2H-PerfluorodecanoI to Perfluorooctanoate D o n a l d F.

AR226-3101 ^3 - GWWJ Huntingdon CONFIDENTIAL DPT434/984093 BACTERIAL MUTATION ASSAY DuPont Specialty Chemicals, Jackson Laboratory, Chambers Works, Deepwater, NJ 08023, USA Research Laboratory Huntingdon Life Sciences Ltd., Eye, Suffolk, IP237PX, ENGLAND Final report issued 1 October 1998 / Company Sanitized.

FOR DU PONT USE ONLY AR226-2943 Ou Pont HLR 651-89 Study Title Inhalation Approximate Lethal Concentration and Pulmonary Pathology of Exposed Rats Author Rudolph Valentine Study Completed On November 22, 1989 Performing Laboratory E. !.

Environmental protection investigations initiated in the 1990s proved extreme environmental hazard of perfluorosur factants based on perfluorooctane carboxylates and perfluorooctanesulfonates including "branched" or "linear fragments" --C7F15COO_ and --C8F17S 0 3_ produced "electrochemically" or by "telomerization of tetrafluoroethylene", respectively.1'2 These substances are extremely stable in the environment, unhydrolyzable, and non-biodegradable, but they are actively bioaccumulated and migrate in the food chains.3''1 Major manufacturers of long-chain fluorocarbons (such as 3M, DuPont, Daikin, etc.) have ceased or cease the production and sale of fluorocarbons, replacing them with alternative shortchain substances.

AR226-3108 HLiufenSticniegndcoens CONFIDENTIAL DPT 438/984469 ASSESSMENT OF READY BIODEGRADABILITY MODIFIED STURM TEST Sponsor Dupont Speciality Chemicals, Jackson Laboratory, Chambers Works, Deepwater, NJ 08023, USA.

The water consumer should not pay for the PFAS pollution. 1 Proposal for a directive amending Directive 2000/60/EC establishing a framework for Community action in the field of water policy, Directive 2006/118/EC on the protection of groundwater against pollution and deterioration and Directive 2008/105/EC on environmental quality standards in the field of water policy (COM(2022) 540 final) 2 Directive 2020/2184 on the quality of water intended for human consumption (DWD) 3 2021 - Sha_Sea Spray Aerosol as a Source of Perfluoroalkyl Acids to the Atmosphere_Field Evidence from Long Term Air Monitoring EST 4 2023_- VITO_PFAS in sea water and seafoam ~ 2/20 ~ Universal PFAS restriction - Consultation on Annex XV report - Additional EurEau comments 18/09/2023 As a matter of example, Chemours, DuPont, 3M and Corteva must pay US$11.5 billion to resolve claims that the chemical manufacturers contaminated drinking water across the United States5. 4 Benefits of a PFAS ban There are wide societal benefits of the prompt PFAS phase-out, in particular related to avoided environmental and health risks.

Kaysen English Translation of Report Summary for DuPont Chemical Solutions Enterprise 27-Jan-03 Company Sanitized.