Absorption throu h t*e s'-'ir. is inportent in the case -t land tetraethyl ard oth=rr organic lead c -g-curds.

S< Lead 2-ethylhexoate (also called lead 2-ethylhexanoate, lead <* -ethyleaproate, or lead "octoate*') is the lead salt of 2-ethylhexoie acid# (Its structural formula istPb (ooC-CH-CHg-CHg-CHg-CH^) $ this was given C2,,HtJ?

.^ Lead 2-ethylhexoate (also called lead 2-ethylhexanoate, lead <* -ethyleaproate, or lead "octoate*') is the lead salt of 2-ethylhexoie acid# (Its structural formula 1st Pb (oQC-CH-CHg-CHg-CHg-CH^) $ this vas given 2f incorrectly on the data sheet sent you by the Ministry of Supply) * It is a typical metallic soap (i*e* the salt of a metal and a fatty acid) and is insoluble in water, but soluble in certain organic solvents* It is not, in the strict usage of the term, an organolead compound, since its structure does not involve any Pb- C linkages, such as are present in tetraethyl- lead and in triethyl- and diethyllead salts* Also it is hardly conceivable that it could produce true organolead compounds, by chemical reaction* either in vitro or in vivo* As a lead salt of an organic acid| it is analogous i n m a n y ways to lead salts of inorganic aids, such as lead chloride, which are ionic in nature5 thus in ether, in which lead 2-ethylhexoate is soluble, it will tend to ionise as follows*- v- :

Furthermore, variations in gasolines from different sources, and in various parts of the country, bring about a wide range of concentrations of tetraethyl lead required to bring the gasoline to a certain minimal anti-knock standard.

Furthermore, variations in gasolines from different sources, and in various parts of the country, bring about a wide range of concentrations of tetraethyl lead required to bring the gasoline to a certain minimal anti-knock standard.

The source of the inorganic lead is conjectural, but in all likelihood some of it was derived from tetraethyl lead by the decomposition of the latter.

Introduction The health aspects of exposures to tetraethyl lead (TEL) have been studied in considerable detail over the years in which this compound has been used extensively as an antiknock additive in gasoline.

I47, He considers lead tetraethyl and tetramethyl os absorbable through skin.

Introduction The health aspects of exposures to tetraethyl lead (TEL) have been studied in considerable detail over the years in which this compound has been used extensively as an antiknock additive in gasoline.

Top p. 147, He considers lead tetraethyl and tetramethyl os absorbable through skin.

Top p. 147, He considers lead tetraethyl and tetramethyl os absorbable through skin.

/U : /// iy-ti.. 3 ml. of tetraethyl lead per gallon^, a4 -irfj^h- still another lateral a_nd, sub^g^u/-untT77~ ' ^ 4-u^f- '*" - / * ^ .'

If it Is existent at all* We have been studying this problem over a period of years and we have failed to find laboratory evidence of the existence of lead absorption among men who have had the most severe and pro longed exposure through skin contact with leaded gasoline# Moreover our observations on experimental animals have proven beyond the shadow of a doubt that the lead absorption associated with skin contact with gasoline containing com raerclal amounts of tetraethyl lead i3 so slight that it can not he measured* It is possible that if one lived in a n _ environment free of lead, and If he at food that was lead free, it might be possible to demonstrate some measureable lead absorption as the result of gross and prolonged contact with leaded gasoline* It is quite certain now, I believe, that the magnitude of such absorption is very materially less than the absorption which results from eating a normal diet with Its normal lead content* With these facts in mind I can not fee l ,that there is any necessity or advisability in taking Mr.fBBJf out of his occupation which Involves the handling of leaded gasoline* This occupation is not a hazardous one* It has not been shown to Involve any lead absorption at all, and since his neurologic lesion is one which may only most doubtfully be attributed to lead ab sorption in any case, I do not feel that he should give up his occupation* Certainly not unless he has some other means of working and earning a living which is just as convenient andduat as lucrative as his present work* Of course is your patient and I shall not give him any such advice as I have indicated in this letter since it Is tipi to you to advise him in accordance with your best judgment* Therefore I am only stating the position I would take If he were my patient.

('iA-tf-O ^<0* L/< X-j*,X3 of tetraethyl lead, caaggr.'

-2- 1 gallon gasoline 3 cubic centimeters tetraethyl lead 1,5 cubic centimeters carbon tetrachloride During the period of the test a record was leapt four times daily of each car paired in the garage.