AR226-1374 ATTACHMENT I TIME LINE FOR C-8 CONTROL PROGRAM & & > -- . 13 7 H March 20, 1981 Informed by 3M of embryotoxlc effects observed in preliminary animal studies with C-8.

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Proven Results.

Wildlife International, Ltd. - 1- Project Number 454A-104 PFOS: A 48-HOUR STATIC ACUTE TOXICITY TEST WITH THE CLADOCERAN {Daphnid magna) ADDENDUM WILDLIFE INTERNATIONAL, LTD.

Wildlife International.

AR226-2586 sjisjcx ir PW5 3iJcs M jr 4* *c4vcj } goa IqcwIka; AOcJ 4o C<*4TM- vSC 61^ fe e v e h o r - k r Am *p fte4tar SoiMp^**?

AR226-2713 AR226-2713 UDR-TR-2004-00025 FINAL REPORT Laboratory-Scale Thermal Degradation of Fluorocarbon Materials July 2004 Final Report - July 6,2004 Laboratory-Scale Thermal Degradation of Fluorocarbon Materials Takahiro Yamada, Ph.D.

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AR226-3385 Subchronic, Developmental, and Reproductive Toxicity o f a Fluoroalkylethyl Phosphate Surfactant J.C.

RECYCLED P'S m I v > C-8 T ' - AMMONIUM PEUFLUOROOCTANOATE CHRONOLOGICAL SUMMARY OF REPORTS Month/Year Sources June 1978 3M Co. discussion BVU UA Peonie 130 nu . ui Samples ?

R&el ,,2106 000380 C-8 BLOOD LEVELS IN FEMALES TRANSFERRED OUT OF TEFLON C-8 LEVEL WHEN AGE LEAVING TEFLON 32 0.140 27 0.192 27 0.570 33 1.300 24 0.110 27 0.110 27 0,078 37 2.400 27 5.100 23 0.061 29 0.270 31 0.190 26 0.045 32 * 0.450 27 0,230 25 0.092 33 0,019 28 2.500 C-8 LEVEL AFTER LEAVING TEFLON 0.086 0.120 0.390 0.980 0.086 0.091 0.065 2.000 4,400 0.053 0.240 0.170 0.041 0.410 0.210 0,092 0.019 2.600 NUMBER OF DAYS BETWEEN SAMPLES 143 127 140 126 128 133 148 139 126 128 130 127 96 127 127 126 133 126 % CHANGE IN C-8 BLOOD LEVELS -38.6 -37.5 -31.6 -24.6 -21.8 -17.3 -16.7 -16.7 -13,7 -13.1 -11,1 -10.5 - 8,9 - 8,9 - 8.7 0.0 0.0 + 4.0 AVERAGE = 129 days -15.3 + 11.7* * The downward trend is statistically significant at 0.05 level using the paired-t test. 12/1/81 0337W 000381

eninge In~rnalCo~mspondence : ddcc:: RR..LL..

7 nTivoadnpeuys ~,~ Richard E.

DDRRAAFFTT FFDooorrNDDoiitssccCuuossspsiiyoo/nnDPPouuNrroppotossDeeissstOOrnnilblyyut---e 33MM AAttttoommeeyy//CClilieenntt PPrriivviilleeggeedd MMataeterriiaall KDKeoeyyNoPPtooiCinnottpssy/---DCoCoNottotttaaggDeeistGGrrirboouvvteee `+ This data represents a FFsinissahhpsDDhaoatttaaofthe presenceofthese substances in Tffciiohssnhihcslssduaaasmmtipapollnereesssp..braeIIsstteeiidnsstioismmnapptosohrnirtastaaponnsntthetotoosteaoatvvofootfihiddedammptaraae.kksiieWnnnhggcaeiitnnoffweferetrehenecncscaeeenssscouoorrbnsctlaundceesisin tcthhoaanttcmmluoosrrieoenwwsoobrrakksenndeeeeoddnss tthoisbeondeonsee,t to be done, oafnddatthai.s and this wWilhlabtewceoocradnicnoatnecdluwdiethisthe will be coordinated with the MMPPCCAA.. 3M has an ongoing assessment at Cottage Groveof the company's `hh3igiMssrttooohurrnaiidccswaaaallntuuesosree,ngsaaoonniiddlnsgmm(aaasnsnuusrufeffasaacsccmtetuuaerrnniindtnggastuoobCffsoFuFtrCCtfa'a'sgcs.e.e)GTT,hrhsioiussvreifinanovcvfeeestshwttaieigtgcaeartotisimo,onnpsaieinnndvvyioom'sllevvneetsss agannrodduffniisdshhw.. a3t3eMMr', 'sssorrielesssee(aasrurccrhfhaiicsseccaoonoodrrddsiiunnbaasttueedrdfawwciiett)hh, tshuerfMacPeCwAataenrsd, the MPCA and asleldoifments all of 33MM''ss ddaattaa iiss ffoorrwwaarrddeedd ttoo tthhee aaggeennccyy..

e0 federal public service HEALTH, FOOD CHAIN SAFETY AND ENVIRONMENT CCIM PFAS Working group report - DGEM DPPC MRBC PFAS: Per- and Polyfluoroalkyl substances Man-made chemicals Produced since 1950s Defined by Carbon Fluor bond (C-F) One of the strongest chemical bonds "forever chemicals" Large group of substances Over 4000 according to OECD PTFE (Teflon) PFOS Definition changed over the years Examples 01 PFASs that already meet the definition by Buck et at. (2-011) r ExampWs of PFA5n thal are added under the new OECD definition" %0. r ri rr r r r pardnmendareadon.cared [Weed Cana OISINCIN 'WM prnarry nurraar {cheat/ 174.1.2.1,1 r pa-diver 44.'4nt ca.54i r55-[7-o poderenenre-nte CMin7S-7]-a rendanrareinderm WON Link 171-15-4 9...4"90r... 140-1234ro CAHN 2f111-2A-1, pironwarNetlahana.s..Llieek len CAGRN 2104-554 / \ Centel taidA-22-1 {05IN 7110JAH1 I-1 e #L NI 0 n, ff 55 C r 81 firoI 11--ci era iii manna er LAICIIN an cramp& el pernuarmanyetrars IFFPgal. emerleenn pnerrellMr; I.