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\ AR226-2409 INTEROFFICE MEMORANDUM Dates From; Dept : Tel No 29-May~i99Q 12:23pm Peter D.

AR226-2905 FOR DU PONT USE ONLY E.

Study Sponsor: Issue Date: Document Reference No.: ELF ATOCHEM 15 -M ar-95 258250 AR226-3011 Bacteria Growth Inhibition Author(s): H.

firft %R> _ TRADE SECRET DuPont-9057 Study Title H-25183: Static, Acute, 96-Hour Screening Test to Pimephales prometas Laboratory Project ED: DuPont-9057 A u t h o r : Alan Samel, M.S.

405 UM - DuPont-5990 TRADE SECRET Study Title H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 5 of 5 Laboratoiy Project I: DuPont-5990 Test Guidelines: U.S.

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r H Mt _ TRADE SECRET M ZZ6 -A 23 DuPont-12991 Study Title H-25767: Static, Acute, 96-Hour Screening Test with Rainbow Trout, Oncorhynchus mykiss Authors: Barbra D.

464 DuPont-l 1414 TRADE SECRET Study Title H-25134: Four-Week Inhalation Toxicity Study in Male Rats Test Guidelines: OECD Guideline for the Testing o f Chemicals Section 4: Health Effects, Number 412 (1981) Author: Linda A.

I AR226-3333 FLUOROPOLYMERS 81-4 PAGE 10 3* Measurement of Residual C-8 Fluorosurfactant Levels on Various Products - C.

AR226-3356 Effects of Fluorotelomer Products on the Bacterial Growth, Degradation of Organic Substances, and Microbial Population from Activated Sludge of a Domestic Sewage Treatment Plant Wana N.1.

y}R,6_ 3W* 000410 RUM- TEFLON FINE POWDER/DISPEKSION OPERATORS C-8 BLOOD SAMPLE RESULTS C-8 in Blood (ppm) First Sample Second Sample Change 26.0 20.0 -6.0 24.0 25.0 +1.0 11.0 8.2 -2,8 9.4 7.9 -1.5 8.2 6.5 -1.7 7.0 7.7 +0.7 6.9 5.9 -1.0 5.6 4.2 -1.4 ..,,4.4 4.3 ; 3.9 4.9 +0.5 5.6 +1.3 3.6 -0,3 3.6 2.7 -0.9 3.5 2.1 4 2.9 2.8 -0.1 2.8 2,8 0.0 2.6 2.4 -0.2 2.5 1.8 -0.7 2.5 2.5 0.0 2.1 1.6 -0.5 1.6 1.5 -0.1 1.5 1.2 -0.3 1.3 1.1 -0.2 JWR:Idr/10/19/83 Bays Between Samples 363 364 391 364 363 364 337 334 365 401 364 362 363 357 365 391 336 349 288 384 366 362 % Per Year Change -23 +4 -24 -16 -21 +10 -16 -27 +13 +27 -8 -25 -40 -3 0 -7 -28 0 -30 -6 -20 -15 000411 TEFLON FEP OPERATORS C-8 BLOOD SAMPLE RESULTS C-8 in Blood (ppm) First Sample Second Sample Change 7.5 6.6 -.9 4.5 3.7 - A 3.1 2.8 -.3 2.1 1.5 -.6 1.8 1.1 -.7 1.8 1,6 -.2 1.6 1,4 -.2 1.25 1.20 -.05 1.20 0.95 1.00 0.79 -.2 -.16 0.86 0.75 -.11 0.75 0.72 -.03 '*i o 00 0.52 0.44 0.51 0.48 -.03 0.42 0.39 -.03 0.41 0.46 +.05 0.38 0.36 -.02 Days Between Samples 362 380 384 364 364 392 393 171 333 391 565 364 365 337 445 363 363 o p-i a % Per Year Change -12 -17 -9 -29 -39 -12 , -9 -18 -7 -8 -4 -15 -6 -6 +12 -5 JWR:Xdr/10/19/8.3 000412 SHORT SERVICE OPERATORS C-8 BLOOD SAMPLE RESULTS Fitie Powder Last Saoule PPM .02 .19 .93 4.00 *** FEP Days in Job 61 212 375 603 .05 95 .05 124 .15 135 .05 165 .23 492 .66 266 PPM Per Year Change +.09 +.24 +.03 - .18 +.15 +.10 +.38 +.09 +.24 -.24 JWRldr 10/19/83 000413 HEW HIRES - TEFLON Date of First Sample 07/28/81 10/01/81 10/07/81 10/13/81 Date Hired 'C-8 Blood Level (ppm) 07/27/81 <0.007 08/03/81 0.009 04/20/81 0.007 04/20/81 : 0.015 Months on Plant Before First -8 Blood Test 0 2 5 1/2 5 3/4 JWR:Idr 10/19/83 000414