Document 8jnQnY3NBvXg1DgZda1bEL3m

AR 2R6 -- [HEO v . -wenn cc: BJ..CR.. Wl MNRCADRRKAHUSI-CKER- CRSD ; . a0 5F.HNC. NBOOYD - CD=&P : E. 1. ou PonT bE Nemour&s COMPANY WILMINGTON. DELAWARE 16358 4. 4, WRIGHR . PERSONAL & CE ONFIDEs NTIAL July 25, 1979 % <g A 4m . 10: R. L. RICHARDS " . - 2229Wm ` FROM: J. W. RAINES jae ORGANIC FLUOROCOMPOUNDS IN BLOOD Published Article CE Yheaproapct0 teedrioOe5 rggaannibiisac tfFhlleuuooArrmi2oenSceroimcipanonkaubyn,Cldhoseomdb.ii_ncpR.allHausmmTSrasoancvoiePsbe,lttaaysianmindane:dVW1.P9f7rr6eo.vmS. albeTBlrnhoeceoyey,d anJdr. TFlueoriene FSrEomStot"cailtifesl,uordientee.rmined by subtracting inorganic oFlur orinoe (MsaLuyrTfa3p0csF,rmCa)-n11c4937s8)In,swbulhciohinocfdoharsmotefthdheeyeDmupsalumoPpmyopoenlnteyisumotfeoxsDepaloultesevPdaoomtftet.dpoerolfrColgnouagnontrircocoh;alin L SrouO p waseltedss (than 1 ppm. July 20, 1979, advised Du Pont: No adverse health effects. DDeecyay arCaetae a"ft%e7r rpermaovIanlonferoymeaerx)p.osure relatively o FFlruooorsinpeerin24urhionuersaltsoo2d2e0camyiecdrogsrlaomvslype(r48424mihcoruor-s 2 410 months). eo FC-143 not adsorbed through skin of rabbits. 8 : o SUPniivkeeenrdssiaattiyoeSo'fssMtiuondlnydeesosonttaa4n,d0p0rbo0ifgeg5se,ss0ot0r0ifselnudpoolrioonycgeheesmaniuchaol 3 plant. . EID107198 : - THERE'S A WORLD OF THINGS WE ANE DOING SOMETHING ABOU) 000162 . 7 R. L. RICHARDS -2- July 25, 1979 e Eight Chinese peasants had significantly lower (0.004 -0.017 pom) blood levels than general U.S. population (0.002- 0.13 ppm). . CD&P and 3M. Analyzed blood of 55 employees at Chambers Works. Average .15 ppm, range 0-.37 ppm. Discontinued blood sampling. Exposure is not to same family of chemicals as that at Washington Vorke (WW) PP&R e AtnoalCy8zed(FbCl-o1o43d) ofat8WWe.mployees potentially exposed " : 2 Laboratorians .4=.5 ppm 2 FOEpPeraPtoolrysmerization "2.2-3.5 ppm 4 TFE Dispersion 9.5-21.1 ppm Polymerization Operators e No adverse health effects attributable to C-8. e Decided not to report to EPA under 8(e) of TOSCA because fluorine in blood per se was disclosed in 1976 article and because no adverse health effect is known, therefore, no substantial risk. Program o o Obtain raw medical study by Corporate MdeadtiacaflromtoWicoenmfpilromyetehsatanldiver function and other medical analyses are normal. Identify personnel in all jobs with potential exposure to C-8 for the past 10 years at WW. eo Analyze blood samples (Jackson Lab will do) of selected additional employees at WW to: - Check all employees currently exposed to C-8. - Verify that fluorine levels in blood are due ctoompCo-u8ndesx.posure rather than other fluoro- : - Define the decay rate (confirm that found by 3M). EID107199 - 8g g 000163 . IR. L. RICHARDS -3- July 25, 1979 . o (Cont'd) - CemopmlmouyneiecsatebefroerseultasddiotfiolnaatlesbtlotoedstssatmoplWesW . are taken. o Dreefseurltbsloaorde sianmpflrionmgWWa.t Dordrecht until additional o TseaxmtpilliengFibbleorosd woifllemdpelcoyiedeesbyacAuSgpursutanc3eabwohuetre ctohnetyapirnoidnugce.3f%ibC-e8r.s from poly TFE dispersion JWR:1db g EID107200 000164