you mentioned in our last joined meeting a paper, which might be usefull for elaborating on combined effects of PFASs.

be used for industrial product range manufacture purposes.

Information Document accompanying The Call for evidence supporting an analysis of restriction options for the PFAS group of substances (fluorinated substance(s)) I.

PFAS in FFF - Timelines Plenary plan Cycle 0 Conformity check 17 February 2022 Conformity check Conformity check starts in Risk Assessment and Socio-Economic Assessment Committees The Annex XV report is for the first time shared with the Committees' members and they have 30 days to conclude on its conformity with REACH requirements. 21 February 2022 Draft conformity check outcome shared with RAC and SEAC 23 February 2022 28 February 2022 Pre-publication of the Annex XV report The Annex XV report is made available to the general public for the first time.

www.axysanalytical.com >)][( A X Y S Axys Analytical Services Ltd 2045 Mills Road West SIDN EY, BRITISH COLUMBIA, CANADA V8L 5X2 T E L 250-655-5800 FAX 250-655-5811 www.axysanalytical.com AXYS Client No.: Client Address: 4731 Weston Solutions Inc. 1400 Weston Way West Chester, PA, US, 19380 The AXYS contact for these data is Candice Navaroli.

3M Environmental Laboratory Method Analysis of Potassium Perfluorooctanesulfonate or Other Fluorochemicals in Liver Extracts Using HPLC-Electrospray/Mass Spectrometry Method Number: ETS-8-7.0 Author: Lisa Clemen, Glenn Langenburg Approved By: Adoption Date: 0 Revision Date: fJfV Laboratory Manager Date Group Leader A diiArU- Technical Reviewer Date O l i n /??

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ENVIRONMENTAL PHYSICAL/CHEMICAL, FATE, EFFECTS AND MONITORING STUDIES GLOBAL BIOMONITORING BACK TO COMPOUNDS STUDY TITLE Accumulation of Perfluorooctane Sulfonate and Related Fluorochemicals in Fish Tissues Accumulation of Perfluorooctane Sulfonate and Related Fluorochemicals in Mink and River Otters Perfluorooctane Sulfonate and related Fluorochemicals in Oyster, Crassostrea Virginica, From the Gulf of Mexico and Chesapeake Bay Perfluorooctane Sulfonate and Related Fluorochemicals in Fish- Eating Water Birds Accumulation of Perfluorooctane Sulfonate in Marine Mammals

S A N IT IZ E D AR jU -co3 $ i REPORT EXPLORATORY 28-DAY ORAL TOXICITY STUDY WITH TELOMER ALCOHOL, TELOMER ACRYLATE PFHS AND PFOS (positive control) BY DAILY GAVAGE IN THE RAT FOLLOWED BY A 14/28-DAY RECOVERY PERIOD NOTOX Project 242933 NOTOX Substances 83484, 83493, 83502, 84456 and 84141 3M Test No.

A(U2rO51% PFOA and Associated Salts Ecotoxicity Elements Title Activated Sludge R espiration Inhibition T es t - F C -1 0 1 5 -X Acute Toxicity o f F C -1 01 5 to the Fathead Minnow, Pim ephales prom elas Growth and Reproduction Toxicity Test with F C -1 01 5 and the Freshw ater Alga, Selenastrum capricornutum Acute Toxicity o f F C -1 0 1 5 to the Daphnd, D aphnia m agna Laboratory or Author 3M Env.

Precise Research.

INTERIM REPORT # 8 - Analysis of Sediment Samples STUDY TITLE Analysis of Perfluorobutanesulfonate (PFBS), Perfluorohexanesulfonate (PFHS), and Perfluorooctanesulfonate (PFOS) in Water, Soil, Sediment, Fish, Clams, Vegetation, Small Mammal Liver and Small Mammal Serum Using LC/MS/MS for the 3M Decatur Monitoring Program DATA REQUIREMENTS EPA TSCA Good Laboratory Practice Standards 40 CFR 792 STUDY DIRECTOR Jaisimha Kesari P.E., DEE Weston Solutions, Inc. 1400 Weston Way West Chester, PA 19380 ' Phone: 610-701-3761 INTERIM REPORT COMPLETION DATE 07/13/06 PERFORMING LABORATORY Exygen Research 3058 Research Drive State College, PA 16801 Phone: 814-272-1039 STUDY SPONSOR 3M Company 3M Building 0236-01-B-10 St.

BIODEGRADATION A R22-0057 FT--3 TEST SUBSTANCE_______________________________________________ Identity: Periluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Rem arks field: The test substance is a white powder of uncharacterized purity.

f\RM >-o\G\ SUMMARY OF THE EFFECTS OF PFC's ON MITOCHONDRIAL BIOENERGETICS IN VITRO The attached diagram describes the metabolic relationship for the various PFC's that were selected for inclusion in this study.