Nees of Denver, for advice on the treatment of a case of tetraethyl lead intoxication which was presumed to have arisen during the course of operations involving the blending of tetraethyl lead with gasoline. ?'

Except in acute fatal tetraethyl lead poisoning, which is quite by itself and differs greatly from fatal inorganic lead poisoning, there are few data.

(2) those associated with exposure to exhaust gases containing finely divided lead, on the part of pilots, passengers and the general public* It seems quite clear to me that we need not concern ourselves with the question suggested under the second heading since the opportunities for exposure to insufficiently diluted exhaust gases in confined or unventilated areas will bo insignificant in the case of aeroplanes as compared to those which have been afforded by automobiles without evidence of human lead accumulation, therefore there remains only the question of exposure to gasoline containing concentrations of tetraethyl lead up to 1 part in 84Q of gasoline# It is apparent that the vapors rising from tanks or open containers will show slightly Increasing amounts of lead, with increasing concentrations of lead In the gasoline* The vaporised lead in the atmosphere as the result of spillage will also be grantor for a given amount of gasoline, with every increase In the concentration of lead In the gaaol'ne* However, the amount of lead which will bo present In vapors above tanks are too small to b8 ~a Dr* R* H* layers of practical Importane, at the specified concentrations.

You are probably aware that historically Switzerland has been very cautious in permitting the a3s of tetraethyl lead and continued to demonstrate reluctance to do so long after the use of tetraethyl lead was widespread in other countries.

rig finely divided lead, on the part of pilots, passengers and the general public* It seems quite clear to me that we need not concern ourselves with the question suggested under the second heading since the opportunities for exposure to Insufficiently diluted exhaust gases in confined or unvenbllated areas will bo Insignificant in the case of aeroplanes as compared to those which have been afforded by automobiles without evidence of human lead accumulation, therefore there remains only the question of exposure to gasoline containing concentrations of tetraethyl lead up to 1 part In 84G of gasoline* It Is apparent that the vapors rising from tanks or open containers will show slightly Increasing amounts of lead, with increasing concentrations of lead in the gasoline.

Tetraethyl lead and other lead atLyl anti knock compound!

Tetraethyl lead and other lead alkyl anti knock compoundt have been among the mod thoroughly Utidied industrial products, from the standpoint of public health.

Turner: J Thank you for your letter of December pth in which you offer to supply ; \ me with information on the use *nd duplication of lead tetraethyl that would, be '-J useful to ne as a member of the Surgeon General's Committee that will consider the question of increasing the permissive amount of tetraethyl lend in gasoline. ij In response to your suggestion I have written to Dr.

You request an opinion on a change that you contemplate adopting in the size of a naming sign for pumps dispensing tetraethyl lead gasoline.

The absorption of tetraethyl lead, because of the chemical nature of the compound and of its early degradation products in the human body is not taken up by the erythrocytes as are the inorganic compounds of lead.

(Ahta^i-h moil g&mjinc* now con tain it, adding tetraethyl lead it not tW only way to Increase a furTl anti knock prttpertlca.

Mr. fils co-Gill further informs me that lie has forwarded cer tain articles on the medical aspects of fcha handling of tetraethyl lead and leaded gasoline, as translated into Spanish.

You are aware, of course, that the quantity of ETHYL fluid which is in Ethyl Gasoline is small, and that the only lead which would be left behind after the emptying of the gasoline tank and after washing, would be small amounts of unchanged and decomposed tetraethyl lead which might remain in the encrustations on the sides of the tank and _ to some degree on the bottom.

Mr. fils co-Gill further informs me that lie has forwarded cer tain articles on the medical aspects of fcha handling of tetraethyl lead and leaded gasoline, as translated into Spanish.

01 400 Table 12 Distribution of Workmen Employed in Mixing Tetraethyl Lead with Gasoline / jAccording to Milligram* of Lead per Liter of Urine Milligram* of Lead Per Liter of Urine 192?