r AG Fluoropolymers ASAHI GLASS FLUOROPOLYMERS USA, IMG AA8.

Soil-Water Partitioning of Fluorotelomer Intermediat Manufacture Fluorotelome Polymers AR226-3354 Telomer Research Program - TRP: Asahi Glass Co.

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EXyBeN. keg ri reAttachment 2 226-7764, Air Sampling Fluorochemical Report [ DuPont Washington Works -- Air Sampling Program Round 7 Exygen Research Report No.

EFCTC HFC and HFO Substances degradation products and TFA yields mimimum structural requirement to potentially form significant yield of TFA is a CF3C group with a halogen such as Designation HFC-125 HFC-134a HFC-227ea HFC-236fa HFC-245fa HFC-365mfc HFO-1234ze(E) HFO-1336mzz(Z) HFO- 1336mzz(E) HCFO-1233zd(E) REFERENCES s 1 2 3 4 5 6 7 8 9 10 p with a halogen such as F or Cl also attached to the C eg CF3CF Complete Name Formula CAS Final Degradation Products number pentafluoroethane 1,1,1,2-tetrafluoroethane 1,1,1,2,3,3,3-heptafluoropropane 1,1,1,3,3,3-hexafluoropropane 1,1,1,3,3-pentafluoropropane 1,1,1,3,3-pentafluorobutane CHF2CF3 CH2FCF3 CF3CHFCF3 CF3CH2CF3 CHF2CH2CF3 CF3CH2CF2CH3 354-33-6 811-97-2 431-89-0 290-39-1 460-73-1 406-58-6 CO2, HF HCOOH, CO2, HF, CF3COOH CO2, HF, CF3COOH CO2,HF, CF3COOH CO2,HF, CF3COOH CO2,HF, CF3COOH Trans-1,3,3,3-tetrafluoroprop-1-ene Cis-1,1,1,4,4,4-hexafluorobut-2-ene Trans- CF3CH=CFH Cis-CF3CH=CHCF3 29118-24- CO2, HCOOH, HF 692-49-9 CO2, HF, insignificant formation of CF3COOH Trans-1,1,1,4,4,4-hexafluorobut-2ene TransCF3CH=CHCF3 66711-86- CO2, HF, insignificant 2 formation of CF3COOH Trans 1-Chloro-3,3,3-trifluoroprop-1- Trans-CHCl=CHCF3 102687- CO2, HF, HCl, zero or ene 65-0 insignificant CF3COOH The TFA yields have been determined using models and/or laboratory experiments.

3M ENVIRONMENTAL LABORATORY Protocol-AnalyticalStudy QuantitativeAnalysisofPerfluorooctaneSulfonicAcid PotassiumSalt (PFOS, T-6295)inCynomolgus Monkeys FollowingAdministrationofa 4- Week CapsuleToxicityStudy 3M ET & SS StudyNumber: AMDT-041598.1 In-VivoStudyReferenceNumber: Covance6329-222 TestSubstance:PerfluorooctaSnuelfoniAccid PotassiumSalt(PotassiuPmerfluorooctane SulfonateC),F17SO3-K'(PFOS,T-6295) Name and AddressofSponsor: 3M ToxicologyServices Building220-2E-02,3M Center St.Paul,MN 55144-1000 Name and AddressofBiological-PhaFsaecility: Covance LaboratorieIsnc.

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6) OECD 471-OPPTS 870.5100, Bacterial reverse mutation test (Ames test), 0623-2140 SANITIZED DEC 0 9 2003 F"AL REPORT Primedica Redfield Test Article: Potassium Perfluorobutane Sulfonate SITEK Study NO. 0623-2140 July 12, 2001 7A. .SITEIC R E S E A R CLHABORATORIES 15235 Shady Grove Road, Suite 303, Rockville, Maryland 20850 301/9264900 FAY 301/926-8891 Study Title Evaluation of a Test Article in the Salmonella typhimurium/Escherichia coli Plate IncorporatiodPreincubation Mutation Assay in the Presence and Absence of Induced Rat Liver S-9 Test Article I.D.

OVERVIEW OF THE GLOBAL TFA MARKET Related with the TFA global market, projections show that the main use will be in Medical Intermediates (see the graphic below).

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Human Health Medicinal Products Sector Survey Impact of Proposed PFAS Restric=on on Pa=ent Access to Medicines & EU Strategic Autonomy Disclaimer: This document was prepared in good faith by represented associa6ons for the purposes of preparing the public consulta6on response to the PFAS Restric6on proposed under Title VIII of the REACH Regula6on.