BACK TO MAIN Type Test ENVIRONMENTAL LABORATORY AQUATIC TOXICITY DATA SHEET EXPLORATORY (RANGE-FINDING TEST) Material T ested lr_ 0 4 A 4 cvW Test Organism>^7y/^; /^/A/A^lSo.

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Corporate Health Physics Corporate Occupational Medicine Corporate Product Responsibility Corporate Toxicology 3M Medical Department 3M Center, 220-2E-02 PO Box 33220 St.

^^-0143 CENTRE FOR XENOBIOTIC RESEARCH University of Dundee, Biomedical Research Centre, Level 5, Ninewells Hospital and Medical School, Dundee, DD1 9SY Study Report Determination of cyanide insensitive Paimitoyl-CoA oxidation in samples from 3M Environmental Laboratory - Covance Studies 6329-183 and 6329-212 Study Number XR0108 Author: .

AR ff.s.6_ OGSG POSF Ongoing- ( 000279 06/22/00 T-7098.1 POSFPK PHARMACOKINETIC STUDY OF POSF IN RATS - STUDY OUTLINE Study Objective: The objective o f this study is to assess the potential for oral absorption, urinary and fecal clearance and biological persistence o f perfluorooctane sulfonyl fluoride (POSF) in male Sprague Dawley rats after a single oral dose.

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) t ii Wa o(0 H HW N iPont Overview o f Fluoi Lers, C-8 and Parker; _ Operations P resented to th e State o f O hio E nviroi February, 20i Columbus, Obi n A gency IO IO Ol AR226- EID781412 ASH028133 EID781414 I I< Fluoiopo lymers "Super" Polymers Chemical resistance across brol temperature range "Slipperiest substance known to m aif Unique properties/High value in use ASH02B135 r-- v00j 1 H * M1 Confidential DuPont Business Information 4 4 Fluoropolynter- 2000 Global Market Demaiwk($Billions) ASH028136 n Major Indtrstties Served by F lu orop olym ers/elastom ers Aerospace/Military Automotive/Transportation Chemical/Petrochemical Processing Semiconductor/Electronics Manufacture Telecommunications Power Generation/Pollution Control Consumer Housewares ASH028137 H-J Htb> H Confidential DuPont Business Information Key requirements: Temperature and chemical resistance; electrical performance; low flammability M ^orfises:, Wire and cable insulation Fuel and hydraulic hoses Seals/bushing Space apparel Societal Benefits: Passenger ASH028138 ` ' \.II.

AR226-2677 O) -vi PROJECT ANNUAL C8 SAMPLING 1997 ANNUAL C8 SAMPLING 1997 ANNUAL C8 SAMPLING 1997 ANNUAL C8 SAMPLING 1997 ANNUAL C8 SAMPLING 1997 ANNUAL C8 SAMPLING 1997 ANNUAL C8 SAMPLING 1997 ANNUAL C8 SAMPLING 1997 ANNUAL C8 SAMPLING 1997 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1998 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 1999 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 ANNUAL C8 SAMPLING 2000 SRCNAME DRLEACHATE DRMW12 DRMW12A DRMW13 DRMW13A DRMW14 DRMW6 DRMW6A TRIP BLANKS DRLEACHATE DRMW12 DRMW12A DRMW12B DRMW13 DRMW13A DRMW14 DRMW6A OUTLET 001 PROPERTY BOUNDARY STREAM SAMPLING POINT#1 STREAM SAMPLING POINT#2 DRLEACHATE DRMW12 DRMW12A DRMW12B DRMW13 DRMW13A DRMW14 DRMW15 DRMW6A OUTLET 001` PROPERTY BOUNDARY STREAM SAMPLING POINT#1 STREAM SAMPLING POINT#2 DRLEACHATE DRMW12 DRMW12A DRMW12B DRMW13 DRMW13A DRMW14 DRMW15 DRMW6A OUTLET 001 PROPERTY BOUNDARY THEME Other liquid Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Blank Water Other liquid Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Other liquid Other liquid Other liquid Other liquid Other liquid Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Other liquid Other liquid Other liquid Other liquid Other liquid Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Groundwater Other liquid Other liquid DATESMPL SMPLT 7/22/1997 FS 7/22/1997 FS 7/22/1997 FS 7/22/1997 FS 7/22/1997 FS 7/21/1997 FS 7/22/1997 FS 7/22/1997 FS 7/22/1997 TB 5/19/1998 FS 5/26/1998 FS 5/26/1998 FS 6/16/1998 FS 5/26/1998 FS 5/26/1998 FS 6/16/1998 FS 5/26/1998 FS 5/19/1998 FS 7/14/1998 FS 5/19/1998 FS 5/19/1998 FS 12/29/1999 FS 7/21/1999 FS 7/21/1999 FS 7/21/1999 FS 7/21/1999 FS 7/21/1999 FS 7/21/1999 FS 7/21/1999 FS 7/21/1999 FS 12/29/1999 FS 12/29/1999 FS 12/29/1999 FS 12/29/1999 FS 10/3/2000 FS 7/19/2000 FS 7/19/2000 FS 7/20/2000 FS 7/20/2000 FS 7/20/2000 FS 7/20/2000 FS 7/20/2000 FS 7/20/2000 FS 10/3/2000 FS 10/3/2000 FS C8 results Envista 111104.xls AR226-2677 DRL SAMPLE NUMBER WWK-DRLEACHATE WWK-DRMW-12 WWK-DRMW-12A WWK-DRMW-13 WWK-DRMW-13A WWK-DRMW-14 WWK-DRMW-6 WWK-DRMW-6A WWK-TRIP BLANK LEACHATE WWK-DRMW-12 WWK-DRMW-12A WWK-DRMW-12B WWK-DRMW-13 WWK-DRMW-13A WWK-DRMW-14 WWK-DRMW-6A 001 OUTLET PROPERTY LINE STREAM I STREAM II WWK-LEACHATE WWK-G-DR-MW-12 WWK-G-DR-MW-12A WWK-G-DR-MW-12B WWK-G-DR-MW-13 WWK-G-DR-MW-13A WWK-G-DR-MW-14 WWK-G-DR-MW-15 WWK-G-DR-MW-6A WWK-001 OUTLET WWK-PROPERTY BOUNDARY WWK-STREAM #1 WWK-STREAM #2 DRL-Z-LEACHATE-UPPER POND INLE DRL-G-MW-12 DRL-G-MW-12A DRL-G-MW-12B DRL-G-MW-13 DRL-G-MW-13A DRL-G-MW-14 DRL-G-MW-15 DRL-G-MW-6A DRL-Z-001 OUTLET DRL-Z-PROPERTY BOUNDARY TOP BOTTOM FILTERED CASNO ANALYTE RsItPost RsItVal UNITS Hit LAB ANALYTE T 3825261 FC-143 62 62 ug/l 1 FC-143 T 3825261 FC-143 <0.1 0.05 ug/l 0 FC-143 T 3825261 FC-143 <0.1 0.05 ug/l 0 FC-143 T 3825261 FC-143 7.0 7 ug/l 1 FC-143 T 3825261 FC-143 15 15 ug/l 1 FC-143 T 3825261 FC-143 <0.1 0.05 ug/l 0 FC-143 T 3825261 FC-143 1.0 1 ug/l 1 FC-143 T 3825261 FC-143 0.36 0.36 ug/l 1 FC-143 T 3825261 FC-143 0.13 0.13 ug/l 1 FC-143 T 3825261 FC-143 56 56 ug/l 1 FC-143 T 3825261 FC-143 <0.10 0.05 ug/l 0 FC-143 T 3825261 FC-143 <0.10 0.05 ug/l 0 FC-143 T 3825261 FC-143 <0.1 0.05 ug/l 0 FC-143 T 3825261 FC-143 9.2 9.2 ug/l 1 FC-143 T 3825261 FC-143 8.7 8.7 ug/l 1 FC-143 T 3825261 FC-143 <0.1 0.05 ug/l 0 FC-143 T 3825261 FC-143 0.27 0.27 ug/l 1 FC-143 T 3825261 FC-143 17 17 ug/l 1 FC-143 T 3825261 FC-143 0.88 0.88 ug/l 1 FC-143 T 3825261 FC-143 1.0 1 ug/l 1 FC-143 T 3825261 FC-143 4.6 4.6 ug/l 1 FC-143 T 3825261 FC-143 34. 34 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.134 0.134 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.081 J 0.081 ug/l 1 FC-143 IN WATER T 3825261 FC-143 5.4 5.4 ug/l 1 FC-143 IN WATER T 3825261 FC-143 3.6 3.6 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.070 J 0.07 ug/l 1 FC-143 IN WATER T 3825261 FC-143 2.5 2.5 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.263 0.263 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.096 0.096 ug/l 1 FC-143 IN WATER T 3825261 FC-143 66. 66 ug/l 1 FC-143 IN WATER T 3825261 FC-143 39. 39 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.54 0.54 ug/l 1 FC-143 IN WATER T 3825261 FC-143 87. 87 ug/l 1 FC-143 IN WATER T 3825261 FC-143 27.4 27.4 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.160 0.16 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.128 0.128 ug/l 1 FC-143 IN WATER T 3825261 FC-143 <0.029 0.0145 ug/l 0 FC-143 IN WATER T 3825261 FC-143 9.8 9.8 ug/l 1 FC-143 IN WATER T 3825261 FC-143 9.9 9.9 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.115 0.115 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.763 0.763 ug/l 1 FC-143 IN WATER T 3825261 FC-143 0.212 0.212 ug/l 1 FC-143 IN WATER T 3825261 FC-143 31.5 31.5 ug/l 1 FC-143 IN WATER T 3825261 FC-143 10.3 10.3 ug/l 1 FC-143 IN WATER Page 1 QUAL_EPA QUALJNHOUSE REVIEW METHODNO PREPMTHD PREPREP UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF None NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS UDF UDF NS C8 results Envista 111104.xls DRL DRY LAB NUMBER RSLTMOD RESULT UNIT 2 ME310-008 62 UG/L 2 ME310-007 < 0.1 UG/L 2 ME310-006 < 0.1 UG/L 2 ME310-003 7.0 UG/L 2 ME310-002 15 UG/L 2 ME310-001 < 0.1 UG/L 2 ME310-005 1.0 UG/L 2 ME310-004 0.36 UG/L 2 ME310-009 0.13 UG/L 2 MF955-004 56 UG/L 2 MF983-002 < 0.10 UG/L 2 MF983-003 < 0.10 UG/L 2 MG105-002 < 0.1 UG/L 2 MF983-001 9.2 UG/L 2 MF983-005 8.7 UG/L 2 MG105-001 < 0.1 UG/L 2 MF983-004 0.27 UG/L 2 MF955-003 17 UG/L 2 MG273-001 0.88 UG/L 2 MF955-001 1.0 UG/L 2 MF955-002 4.6 UG/L 1 3300039-1 34.

RECYCLED I-pV*) AR226-2702 AR226-2702 TORONTO WORKSHOP MATERIALS Septem ber 13-14,2004 _ Atmospheric Chemistry of Fluorotelomer Alcohols (Part 2) Robert Waterland DuPont Engineering Research & Technology, Wilmington, DE Outline What do we know for certain?

AR226-2765 FOR DU POST USE ONLY Copies to: HaclroiT t .E * Pont de Nemours and Company Haskell taboracer, far Toxicology a,,d Industrial Medicine fcllcton Road, Newark, Delaware J9711 HASKELL LABORATORY REPORT NO. 329-81 Material Vested ' !

% Material Tested; Material Submitted AR226-2829 Copies t0\ i Haskell L a b o rstoryyUtfoorrn,TrooxxiiccoolloogOyUrSartd inCdumsptar"iyal Medicine HASKELL LABORATORY REPORT NO. 244-71 "" rganic Chemicals Department 'Jackson Laboratory Haskell No.; 6917 Procedur ACUTE ORAL Test ~L "-s zstz&z --------- ------------- ------------- -- young adult r ' the livers were removed for gravimetric Company Sanitized.

FOR DU PONT USE ONU AR226-2911 Haskell LaEb.orIa.todEryulNstfPeooownrnat-TRkd,ooeaxDdiNc,eoelFalmow.ogauy0rres. anaBnd1od9x7I1n5C10do,u.

AR226-3028 DuPont m R 712-95 HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE STATIC, ACUTE 96-HOUR SCREENING TEST OF H-21209 TO FATHEAD MINNOWS, gimanhalas pgomal&s PURPOSE: This is a rangefinding study designed to provide an estimate of aquatic toxicity using fixed test concentrations and data measurements at predetermined intervals.

AR226-3124 DuPont-3104 HASKELL LABORATORY FOR TOXICOLOGY AND INDUSTRIAL MEDICINE H-24119: STATIC, ACUTE 48-HOUR SCREENING TEST TO Daphnia magna PURPOSE: This is a rangefinding study designed to provide an estimate o f aquatic toxicity using fixed test concentrations and data measurements at predetermined intervals.