TABLE 1 Instrum ental Methods -- C apabilities Instrum ents ______________ Method Morphology Optics D iffraction Chem ical Analysis* LM: light m icroscope DS: d is p e rsio n staining XRD: x -ra y diffraction SEM: scanning electron m icroscope TEM: transm ission electron m icroscope EMA: elec tro n m icroprobe EMMA: electro n m icro sco p em icroprobe analyzer IMA: ion m ic ro p ro b e >1 /on >5 /un NO >1 /un >1 /un NO ^ 0 . 005 m NO > 0. 001 /un NO >5 /un NO > 0 . 005 /un NO >5 /un NO NO NO YES NO YES NO YES NO NO NO YES YES NO** YES YES YES ^diffraction methods indirectly analyze chem ically by identifying the crystalline phase present; chem ical analysis by electron optical instrum ents may utilize energy o r wavelength dispersive x -ray analyzers **may be fitted with energy o r wavelength dispersive x -ray analyzers waiter c. mecrone associates, inc, @tmheicrosc pe Incorporating "Crystal Front" .

-1 * E A medically oriented "detective story."

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Talcum Products Collected and Analyzed for Asbestos Under FY 75 Import Cosmetic Sampling Program Report Entry No. -9 } 118 ). 131 f. 136 Sample No. 002303 021553 026578 026586 j. 145 028343 3. 163 DI 008-223 H 7. 164 DI 008-224 H 3. 165 9. 166 3. 177 1. 178 DI 008-225 H DI 008-226 H DI 012-689 H DI 012-690 H 2. 179 DI 012-691 H Brand Name Para 0 Bebe Talco Boldoot Talkpoeder Pola Maquifard Face Powder Naris Loose (Face) Powder (Pink 2) Bal a Versailles Po tdre de Bo doir Caron Fleurs de Rocaille Talc Tabac Original Deodorant Body Talc Magno Talco Perfumado Rose The Talc Parfume Maja Dusting Powder Fidji Do celine Dusting Powder Je Reviens Talc Manufacturer Saboaria Perfumarla Boldoot Pola Cosmetics Co, Ltd.

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COSMETIC TALC Minerals of Interest The asbestiforin minerals of p r i m a ry concern in regard to cosmetic talc are fibrous serpentine (chrysotile) and fibrous araphiboles (tremolite and anthophyllite)* Analytical Techniques Used at FDA The main techniques used at FDA are differential thermal analysis for the determination of serpentine minerals and x-ray diffraction for the determination of amphibole minerals.

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(C) Basis for toxicity for each hazardous material such as established OSHA standard (TLV), in appropriate units and/or LD^q > showing amount and mode of exposure and species or LC^q showing concentration and species.

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DEPARTMENT OF HEALTH, EDUCATION, AN FOOD AND DRUG ADMINISTRATION [21 CFR PARTS 121, 128, 133] ASBESTOS PARTICLES IN FOOD AND DRUGS NOTICE OF PROPOSED RULE MAKING L A ^ 7 0 7 Co The Commissioner of Food and Drugs has received a petition from the Center for Science in the Public Interest, 1779 Church Street, NW., Washington, DC 20036, and the Environmental Defense Fund, 1525 18th Street, NW. , Washington, DC 20036, requesting promulgation of regulations under the Federal Food, Drug, and Cosmetic Act to prohibit the adulteration of food and drugs with asbestos.

SECTION II.B