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HSE Health and Safety Executive Occupational, domestic and environmental mesothelioma risks in Britain A case-control study Prepared by the Institute of Cancer Research and the London School of Hygiene and Tropical Medicine for the Health and Safety Executive 2009 RR696 Research Report IV CONTENTS SectionPage Executive summary ix 1 Introduction 1 2 Methods 2.1 Study design 2.2 Case and control ascertainment and data collection 2.3 Statistical methods 3 3 3 4 3 Results 3.1 Recruitment 3.2 Occupational exposure 3.3 Low exposure analysis 3.4 Summary analyses of all subjects 9 9 14 33 38 4 Discussion 4.1 Occupational exposure 4.2 Low-risk occupations 4.3 Non-occupational exposure 4.4 Background incidence rate 4.5 Latency, period of exposure and future trends 4.6 Risks to carpenters in the UK and elsewhere 4.7 Contribution of amosite to UK mesothelioma incidence 4.8 Speculations on the contribution of chrysotile 4.9 Current asbestos hazards 43 43 44 44 44 45 46 46 47 48 5 References 49 6 Appendix tables 53 V TABLES AND FIGURES Figure 3.2.1 Proportion of all men reporting asbestos exposure by year started job Table 2.3.1 Highest mesothelioma proportional mortality ratios (PMRs) for males aged 16-74 in Great Britain, 1991-2000 Table 2.3.2 Classification of job categories with average national mesothelioma PMRs Table 3.1.1 Study recruitment Table 3.1.2 Source of mesothelioma and lung cancer case notification Table 3.1.3 Response rates by deprivation Table 3.1.4 Grounds of diagnosis of interviewed mesothelioma cases Table 3.1.5 Median (and range) of age at interview Table 3.1.6 Residential region atinterview Table 3.2.1 Interviewed mesothelioma cases and controls by job category, year of birth and sex Table 3.2.2 Numbers of mesothelioma cases and controls who worked for at least 5 years in various occupations Table 3.2.3 Odds ratios for males by age started work and total duration in high or medium risk occupations and in carpentry Table 3.2.4 Odds ratios for males by duration of employment in high or medium risk occupations and in carpentry before and after age 30 Table 3.2.5 Odds ratios for males by weighted duration in high or medium risk occupations before and after age 30 Table 3.2.6 Job category and reported asbestos exposure in all men before age 30 Tables 3.2.7 a-g Reported contact with AIB, lagging and/or sprayed coatings before age 30 by job duration for each job category Table 3.2.8 Type of reported direct (self) contact with AIB, lagging and/or sprayed coatings before age 30 by job category Table 3.2.9 Numbers of male mesothelioma cases and controls by last job before interview and year of birth Table 3.2.10 Main occupation while aged under 30 by last job before interview - all men Table 3.3.1 Low risk occupational groups and reported asbestos exposure at work Table 3.3.2 Univariate analysis of other reported occupational asbestos exposures before age 30 among men and women in low risk jobs Table 3.3.3 Univariate analysis of DIY exposures among men and women in low risk jobs Table 3.3.4 Univariate analysis of reported domestic exposures a mong men and women in low risk jobs Table 3.3.5 Univariate analysis of residential exposures among men and women in low risk jobs Table 3.3.6 Univariate analysis of smoking among men and women in low risk jobs and in all subjects Table 3.4.1 Univariate analysis of reported domestic exposures among all subjects Table 3.4.2 Mesothelioma cases in men and women attributed to asbestos exposure in each exposure category Table 3.4.3 Male cases and controls born in 1950 or later who began work in 1970 or later, and numbers of cases attributed to asbestos exposure 29 5 6 10 11 11 12 12 13 17 18 22 22 23 24 26 28 30 32 33 34 34 35 36 37 39 40 41 VI Appendix table 3.1 Strategic Health Authority at interview (English subjects only) Appendix tables 3.2.2 c, d and e Men born after 1940 and 1925-39, and all women.

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file:///C|/Users/MadeK42/Desktop/whysner-upload/Whysner,%20John%20--%2010-27%20-08%20am%20Part%20I.txt 1 1 SUPERIOR COURT OF THE STATE OF CALIFORNIA 2 FOR THE COUNTY OF LOS ANGELES 3 DEPARTMENT 323 HON.

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230 Air System Equipment Allen Cooler & Ventilator, Inc.

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