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^ P ,,Z G - l g Jf. 3M Company EPI-0016 Page 1 of 30 FINAL REPORT Epidemiology Medical Department 3M Company S t Paul.

3M Specialty Materials October 3, 2002 3M Center St.

J rf 3M Katherine E.

fiR RR & _ tb&o SRPTT-7(/ MIN 314/022208 PERFLUOROOCTANESULFONYL FLUOORRIDE (PO SF) BACTERIAL REVERSE MUTATION TEST Sponsor 3M Center 3M Corporate Toxicology Building 220-2E-02 St Paul MN 55133-3220 USA Research Laboratory Huntingdon Life Sciences Ltd.

ZedQ -093RECEIVED OPPT CB1C 03SEP25 September 23, 2003 iSjL*jn / Duftmt Haskell Laboratory for Health and Environmental Sciences Elkton Road.

NORTHERN KENTUCKY OFFICE SUITE 340 1717 DIXIE HIGHWAY COVINGTON, KENTUCKY 41011-4704 606-331-2838 513-381-2838 FAX: 513-381-6613 DAYTON, OHIO OFFICE SUITE 900 110 NORTH MAIN STREET DAYTON, OHIO 45402-1786 937-228-2838 FAX: 937-228-2816 TAFT, STETTINIUS & HOLLISTER LLP 425 WALNUT STREET, SUITE 1800 CINCINNATI, OHIO 45202-3957 513-381 -2838 FAX: 513-381-0205 www.taftlaw.com CLEVELAND, OHIO OFFICE 3500 8P TOWER 200 PUBLIC SQUARE CLEVELAND, OHIO 44114-2302 216-241-2638 FAX: 216-241-3707 COLUMBUS, OHIO OFFICE 21 east state street columbus, ohio 43215-1221 614-221-2838 FAX:614-221-2007 R o b er t A.

Toxicological Summary PFOS Dietary Chronic Definitive Reproductive Study: Mallard Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro, potassium salt.

A P.& 2 .6 ,0616 n H'c n1 ir-!

3M General Offices 3M Center St.

ATTACHMENT TO LETTER OF 1/18/05 3M FLUOROCHEMICAL SUBMISSION AZ2r no I 3M FLUOROCHEMICAL SUBMISSION TOXICOLOGY, EPIDEMIOLOGY AND MEDICAL SURVEILLANCE Multiple Chemicals o "Inter-Species Comparison of Mechanisms Fluorochemical Toxicity following Intraperitoneal dosing of perfluorooctanesulfonate (PFOS, T-6295) or ammonium perfluorooctanoate (APFO, T-6889) in Rats and Guinea Pigs and oral dosing of N-ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316) in Rats," 3M Medical Department Corporate Toxicology, DT15-A, May 24, 2004. 2.

AR226-2199 Chris E Shoop 09/05/2001 11:16 AM To: Debbie J Mulrooney/AE/DuPont@DuPont ' cc: Stephen J Gissy/AE/DuPont@DuPont, Robert L Ritchey/CL/DuPont@DuPont, Robert F Pinchot/DEV/AE/DuPont@DuPont, M.

AR226-2519 Ta-Wei Fu /I 11/12/02 02:13 PM To: Charles J Noelke/AE/DuPont@DuPont cc: Steven H Swearingen/AE/DuPont@DuPont Subject: Eureka!

AH&&.6- $6(K A preliminary list of published references being considered in the update to the science Prepared following the completion of the environmental and human health risk assessments of the 4 notified polymers.

p. 1 A/Ua- 36!