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G Model CBI-6097; No. of Pages 5 ARTICLE IN PRESS Chemico-Biological Interactions xxx (2009) xxxxxx Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: www.elsevier.com/locate/chembioint Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: Induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair Yongyi Bi a,, Yuhong Li a, Mengmeng Kong a, Xiao Xiao a, Zhiwei Zhao a, Xiaoqing He b, Qiang Ma b a School of Public Health, Wuhan University, 185 Donghu Rd., Wuhan, Hubei 430071, China b Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Rd., Morgantown, WV 26505, USA article info Article history: Available online xxx Keywords: Benzene Microarray CYP4F3 DNA-PKcs DNA double strand break repair abstract Benzene causes hematotoxicity and leukemia in humans.

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ORIGINAL ARTICLE Leukemia (2006) 20, 21472154 & 2006 Nature Publishing Group All rights reserved 0887-6924/06 $30.00 www.nature.com/leu Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells H Gal1,2,3, N Amariglio2, L Trakhtenbrot2, J Jacob-Hirsh2, O Margalit2, A Avigdor4, A Nagler4, S Tavor5, L Ein-Dor3, T Lapidot6, E Domany3, G Rechavi2 and D Givol1 1Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel; 2Department of Pediatric HematoOncology, Chaim Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; 3Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel; 4The Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, Israel; 5Department of Hematology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel and 6Department of Immunology, Weizmann Institute of Science, Rehovot, Israel Tumors contain a fraction of cancer stem cells that maintain the propagation of the disease.

Dioxin exposure study in Midland, MI BACKGROUND LEVELS OF PCDDs, PCDFs, AND PCBs IN BLOOD, SOIL, AND HOUSEHOLD DUST IN THE GENERAL POPULATION OF MICHIGAN, USA Garabrant D1, Franzblau A1, Lepkowski J2, Adriaens P3, Demond A3, Hedgeman E1, Knutson K1, Zwica L1, Chen Q4, Olson K2, Ward B2, Towey T3, Ladronka K2, Sinibaldi J2, Chang S-C3, Lee S-Y4, Gwinn D5, Sima C4, Swan S5, Gillespie BW4 1Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S Observatory, Ann Arbor, MI 48109; 2Survey Research Center, Institute for Social Research, University of Michigan, 426 Thompson Street, Ann Arbor, Michigan 48104; 3Department of Civil and Environmental Engineering, University of Michigan College of Engineering, 1351 Beal, Ann Arbor, MI 48109; 4Department of Biostatistics, University of Michigan School of Public Health, 109 S Observatory, Ann Arbor, MI 48109; 5Center for Statistical Consultation and Research, Horace Rackham School of Graduate Studies, Ann Arbor, Michigan 48109 Introduction and Study Goals This paper describes the pattern of blood dioxin concentration and the factors that explain variation in blood dioxin concentrations in an area of Michigan (Jackson and Calhoun counties) that is believed to be representative of the general population.