Chemico-Biological Interactions 183 (2010) 349356 Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: www.elsevier.com/locate/chembioint DNA binding and photocleavage properties and apoptosis-inducing activities of a ruthenium porphyrin complex [(Py-3 )TPP-Ru(phen)2Cl]Cl and its heterometallic derivatives Yanan Liu a, Tianfeng Chen a,b, Yum-Shing Wong b, Wen-Jie Mei a,c, Xiao-Mei Huang c, Fang Yang a, Jie Liu a,, Wen-Jie Zheng a, a Department of Chemistry, Jinan University, Guangzhou 510632, PR China b Department of Biology, The Chinese University of Hong Kong, Hong Kong, PR China c School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China article info Article history: Received 30 September 2009 Received in revised form 22 November 2009 Accepted 24 November 2009 Available online 1 December 2009 Keywords: Ruthenium porphyrin complex DNA-binding Photocleavage Apoptosis Mitochondria abstract The interactions of a ruthenium porphyrin complex [(Py-3 )TPP-Ru(phen)2Cl]Cl (phen = 1,10phenanthroline, (Py-3 )TPP = 5-(3 -pyridyl-10,15,20-triphenylporphyrin) (1) and its heterometallic derivatives, [Ni(Py-3 )TPP-Ru(phen)2Cl][PF6] (2) and [Cu(Py-3 )TPP-Ru(phen)2Cl][PF6] (3), with calf thymus DNA have been investigated by spectroscopic and viscosity measurements in this study.

G Model CBI-6098; No. of Pages 6 ARTICLE IN PRESS Chemico-Biological Interactions xxx (2010) xxxxxx Contents lists available at ScienceDirect Chemico-Biological Interactions journal homepage: www.elsevier.com/locate/chembioint The fate of benzene-oxide Terrence J.

Philadelphia Chromosome - Positive Acute Lymphoblastic Leukemia Farhad Ravandi, MDa,*, Partow Kebriaei, MDb KEYWORDS Acute lymphoblastic leukemia Philadelphia chromosome BCR-ABL Tyrosine kinase inhibition Allogeneic stem cell transplant BIOLOGY The Philadelphia (Ph) chromosome, a short chromosome 22, results from the reciprocal translocation between chromosomes 9 and 22 that fuses the breakpoint cluster region (BCR) gene on chromosome 22 to the Ableson (ABL) gene on chromosome 9.1,2 The protein product of the fusion gene, BCR-ABL, has enhanced tyrosine kinase activity leading to the constitutive activation of several downstream pro-proliferative and pro-survival signaling pathways, and hence to leukemogenesis.3 The Ph chromosome is the most frequent cytogenetic abnormality in adult patients with acute lymphoblastic leukemia (ALL), occurring in approximately 20% to 30% of adults but only in about 5% of children with this disease.4 The incidence rises with age, and it occurs in approximately 50% of patients older than 50 years.5 Depending on the location of the breakpoint within the BCR gene, two major varieties of the oncogenic protein of differing sizes have been recognized.

Analytical Biochemistry 327 (2004) 184199 ANALYTICAL BIOCHEMISTRY www.elsevier.com/locate/yabio Rapid determination of six urinary benzene metabolites in occupationally exposed and unexposed subjects Suramya Waidyanatha,a Nathaniel Rothman,b Guilan Li,c Martyn T.

American Journal of Hematology 79:194197 (2005) ThalidomideDexamethasone as Primary Therapy for Advanced Multiple Myeloma Michael Wang, Donna M.

Dioxin exposure study in Midland, MI CONSIDERATIONS FOR MANAGING A LARGE, MULTI-FACETED STUDY INVOLVING MULTIPLE ORGANIZATIONS Ward B1, Ladronka K1, Skoman, M1,Olson K1, Sinibaldi J1, Lepkowski J1, Blackburn Z1 , Freeland S1, Franzblau A2, Hedgeman E2, Zwica L2, Towey T3, Demond A3, Garabrant D2 1Survey Research Center, Institute for Social Research, University of Michigan, 426 Thompson, Ann Arbor, MI 48109; 2Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S Observatory, Ann Arbor, MI 48109, 3Department of Civil and Environmental Engineering, University of Michigan College of Engineering, 2340 G.G.

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