April27,2000 One GenerationReRroduction Study ofPFOS Mevalonic Acid/CholesteroClhallengeand NOEL InvestiL-atiionnRats Draft Study Outline Study ObjectivesT:hisstudywillserveasa follow-upstudytoCombined Oral(gavage FertilitDye,velol2mentaland Perinatal/PostnaRteaplroductionToxicityStudy of PFOS in Rats(ArgusProtocol418-008,3M studynumber T-6295.9).The objectiveosf thestudy areasfollows: 1) todeterminewhetherornotco-administratiofnmevalonicacidor cholesteroclan preventor antagonizetheadversematemal and fetaleffects(reducedmatemal body weightgain,increasedpercentstillbordne,creasedbirthweightand decreasedpup survivalo)bservedinthepreviousstudy;and 2) torefmetheno observedeffectlevel(NOEL).

Argus PK Outline 5/03/2000 One Generation ReiproductionStudy of PFOS in Rats Pharmacokinetic Analysis Study Outline Study Objectives:This studywillserveas a follow-upstudytoCombined Oral(gava2e) FertiliiDye.velopmentaland Perinatal/PostnaRteaplroductionToxiciiyStudyof PFOS i Rats(ArgusProtocol418-008,3M studynumber T-6295.9).The objectivoef thestudy isto gainadditionaplhannacokinetc(PK) dataon PFOS inpregnantratsand theirpups.

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NORTHERN KENTUCKY OFFICE SlilTE 340 1717 DIXIE HIGHWAY COVINGTON, KENTUCKY 41011.4704 606-331-2838 513-381-2838 FAX: 513-381-6613 DAYTON, OHIO OFFICE SUITE 900 110 NORTH MAIN STREET DAYTON, OHIO 45402-1786 937-228-2838 FAX: 937-226-2816 ROBERT A.

OPff- 9- 00 p.1 :3 6 95" TAFT, STETTINIUS & HOLLISTER LLP NORTHERN KENTUCKY OFFiCE CLEVELAND, OHIO OFFICE SUITE 340 3500 BP TOWER 1717 DIXIE HIGHWAY COVINGTON, KENTUC4K 25YW4A1L0N1U1T-4 S7 TR0E4EfTCSL UE ITV EE1L 80A0ND, OHIO 200 PUBLIC SQUARE 4l114-2302 650163--333611--22863386 CINCINNATI OHIO 45202-3957 FAX: 513-381-6613 , FAX2:16:-12641.2-24813a87o7 COLUMBUS, OHIO OFFICE DAYTON, OHIO OFFICE 513-381-2838 21 EAST STATE STREET SUITE 900 205 COLUMBUS, OHIO 432154221 110 NORTH MAIN FS AX :T 513-R 381 -E 0 ET 614-221-2836 DAYTON, OHIO 45402-1786 FAX :614-221-2007 937-228-28 3 8 FAX : 937-226-281 6 www.taftlaw.co m ROBERT A.

~rw _ loC~6 P. 16 f.s--o TAFT, STETTINIUS & HOLLISTER LL P NORTHERN KENTUCKY OFFICE CLEVELAND, OHIO OFFICE SUITE 171 7 COVINGTON, KIENTUCKYr 10114704 606-331 -2838 .381-2 3 FAX : 53 13-381-6613 340 3500 BP 425 WALNUT STREET, SUITE 1800 CINCINNATI, OHIO 45202-3957 TOWE R 200 PUBLIC SQUAR E CLEVELAND OHIO 114-2302 , 216-241-2838 FAX: 216-241-3707 COLUMBUS, OHIO OFFICE DAYTON, OHIO OFFICE 513-381-2838 21 EAST STATE STREET 11S 0 U NIO TR ET9 H0M 0 A FIA N X S:T 513R -381 -E 02E 05 T COLUMBUS, OHIO 43215-4221 614-221-2838 DAYTON, OHIO 454 02-1 937-228-2838 FAX : 937-228-2816 7 8 6 www .taftlaw .co m FAX :614-221-2007 -3 73 ROBERTA . (513) 357-9638 bilo tt@taftlaw.com BILOTT L /y October 2, 2006 C-) 4 FEDE L E RESS l ~~~~~~ Il I I ~ , II II ~ ~ I I ~ RA XP TSCA Document Processing Center (7407M) b E F A(,I -ll 1o11 111 b_1 , b[1 51 11ti,, =- EPA East - Room 6428 CD Attn : Section 8(e)/FYI -- U .S .

~J<7 .~ ~ - 3175~ Sanitized Version for th e AR-226 Public Electronic Docket (CBI and copy restricted documents removed) Index DOCUMENT DESCRIPTION NO.

0% Solom Water aEb6y034 LadYy3ol3e STL | - S1EEtTLsirDenpevnere fa rn | J---- PFOAIPFOS Analysis | -- SSSRormat n, | ee Aoim t" | September 8, 2007 rin oerzsows oz Table Of Contents Standard Deliverables i Report Contents Total Number of Pages pSTahrtesCaaonnfedhaiLsraStdaervDaaenrlddiDhveeeRrelpaobrwtlreCposacvekrlapgee.Tahrrecponosirdserecdotmprlelte [] nr lege ited hi Tobieof onreehesd + Table of Contents + Case Narrative + Executive Summ -Daeterctiyon Highlights + Methods Summary + Method/Analyst Summary + LotSample Summary + Analytical Resuls + QCDara Associaton Summary | + Chaln-of-Custody DEP2.SDWB-000222 | CasDe7HN2a90r3r0a8tive pTreeascsectnotreeddraniscehDwesinrvhaeptrohreitzmweeetrshooUdaSsnEaihPnzdAoicdstpefrdr.ohiDsedipomarananmaeoctseirosnsa1at1nds4ahaontannolelsmwseortrhke.odpsTrohSviudsemadmapolnneSspaacghe atashee1to assist in the mrpratonofthe resus.

@ ETT JGiesy@aol.com 04/07/2003 11:08 AM : mim To: dlbacon@mmm.com wkreagen@mmm.com CO: Subject: paper Dale and Bill: I have a paper that has been submitted to Chemosphere on human blood by Olsen et al (3M).

Table des matires Introduction................................................................................................................................2 NEHAP : Environnement-sant en Belgique...............................................................................6 `'Aux dbuts..." .......................................................................................................................6 Les origines internationales du NEHAP ............................................................................62 Accord de coopration du 10 dcembre 2003...................................................................6 Les acteurs..............................................................................................................................7 La CIMES .............................................................................................................................7 La cellule nationale environnement-sant.........................................................................7 Diffrents programmes oprationnels...................................................................................9 NEHAP 1 : Base stratgique (2003-2010) .........................................................................10 NEHAP 2 : Programme oprationnel (2011-2020) ...........................................................10 NEHAP 3 : Dfis pour le futur (2022-2029)..............................................................................11 Les fiches d'action du NEHAP 3 ...............................................................................................12 Fiche 1 : Adaptation aux effets du changement climatique sur la sant en Belgique......12 De la gestion de crises la gestion des risques sanitaires .................................................12 Fiche 2 : Systme de sant durable faible mission de carbone ....................................24 Fiche 3 : Forte Chaleur et Pics d'Ozone...............................................................................34 Fiche 4 : valuation des risques chimiques - PARC, Partnership for the Assessment of Risks from Chemicals...........................................................................................................52 Fiche 5 : Plan d'action nationale sur les perturbateurs endocriniens ...............................64 Fiche 6 : Formation des professionnels de sant ...............................................................76 Fiche 7 : Surveillance Moustiques Exotiques et autres vecteurs : surveillance des moustiques exotiques .........................................................................................................87 Fiche 8 : Moustiques Exotiques et Autres Vecteurs : tiques..............................................98 Annexe I : le portfolio national...........................................................................................117 Annexe II : L'importance du NEHAP ...................................................................................198 Annexe III : Les partenaires du NEHAP...............................................................................200 1 Introduction NEHAP est l'acronyme du Plan National d'action Environnement-Sant (en anglais : National Environment Health Action Plan).

ARDGOIE 7 EVALUATION OF MUTAGENICITY STUDIES DEVELOPED ON (PFOS) PERFLUOROOCTANE SULFONATE PREPARED BY PROF.

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AR226 -- 107] company Cele Page Lof 121 FINAL REPORT Epidemiology, 220-3W-05 Medical Department 3M Company St.