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f fi# - 3-T7 SRPT T-76UI MIN 315/022356 PERFLUOROOCTANESULFONYL FLUORIDE (POSF) T ~lbbl3> IN VITRO MAMMALIAN CHROMOSOME ABERRATION TEST IN HUMAN LYMPHOCYTES Sponsor 3M Center 3M Corporate Toxicology Building 220-2E-02 St Paul MN 55133-3220 USA Page 1 of 31 Research Laboratory Huntingdon Life Sciences Ltd Woolley Road Alconbury Huntingdon Cambridgeshire PE284HS ENGLAND Report issued 22 October 2002 001542 MIN 315/022356 CONTENTS Page CONTENTS................................................................................................................................ 2 COMPLIANCE WITH GOOD LABORATORY PRACTICE STANDARDS..................... 4 QUALITY ASSURANCE STATEMENT................................................................................... 5 RESPONSIBLE PERSONNEL................................................................................................... 6 SUMMARY................................................................................................................................ 7 INTRODUCTION.................................................................................................................. 8 TEST SUBSTANCE.............................................................................................................. 10 EXPERIMENTAL PROCEDURE......................................................................................... 11 ASSESSMENT OF RESULTS................................................................................................... 15 MAINTENANCE OF RECORDS.............................................................................................. 15 RESULTS.............................................................................................................................. 16 CONCLUSION........................................................................................................................... 17 REFERENCES............................................................................................................................ 18 :2 : 001543 MIN 315/022356 COMPLIANCE WITH GOOD LABORATORY PRACTICE STANDARDS The study described in this report was conducted in compliance with the following Good Laboratory Practice standards, with the exceptions stated below, and I consider the data generated to be valid.

Autografting Bone Marrow Transplantation (2001) 27, 821828 2001 Nature Publishing Group All rights reserved 02683369/01 $15.00 www.nature.com/bmt Thiotepa, busulfan, cyclophosphamide (TBC) and autologous hematopoietic transplantation: an intensive regimen for the treatment of multiple myeloma A Shimoni1, TL Smith2, A Aleman1, D Weber3, M Dimopoulos3, P Anderlini1, B Andersson1, D Claxton1, NT Ueno1, I Khouri1, M Donato1, M Korbling1, R Alexanian3, R Champlin1 and S Giralt1 1Department of Blood and Bone Marrow Transplantation, 3Department of Lymphoma and Myeloma, and 2Department of Biostatistics, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA Summary: The study was designed to evaluate the efficacy and safety of an intensive, tri-alkylator conditioning regimen, consisting of thiotepa, busulfan and cyclophosphamide (TBC), prior to autologous hematopoietic cell transplantation in patients with multiple myeloma (MM) and to analyze factors associated with outcome.

http://www.usatoday.com/yourlife/health/2010-09-14-conflictl4_ST_N.htm?

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Message From: Sent: To: Subject: STEVENER, SCOTT E [AG/1000] [/0=MONSANTO/OU=NA-1000-01/CN=RECIPIENTS/CN=649167] 8/18/2008 1:51:08 PM PEIRCE, BOB [AG/1000] [bob.peirce@monsanto.com]; YOUNG, GLYNN [AG/1000] [glynn.young@monsanto.com] FYI - Solutia finds PCBs outside Anniston High School - The Anniston Star (Alabama) The Anniston Star (Alabama) 08/15/2008 Solutia finds PCBs outside Anniston High School By Michael A.

Ethanolamines/Glycol Ethers Tier 3 Procedure Section Number: Issue Number: Original Date: Revision Date: Title: References: 5016 1.1 11-19-96 Author: Tim Dill/Townsend 02-17-97 Operation of the DV-135 Temporary Charcoal Filter Glossary Of Equipment Identification (Text #114) 1713 Use of Flexible Hoses 1703 Blowing Out Product Lines and Equipment with Nitrogen 2000 Quick Disconnects and Bleeds 5016.

Section Number: Issue Number: Original Date: Revision Date: Title: References: Ethanolamines/Glycol Ethers Tier 3 Procedure 2001 1.3 11-11-91 Author: Mike Viator 04-03-95 Block 55 Safety Valve Policy/Maintenance Glossary Of Equipment Identification (Text #114) 2001 Block 55 Safety Valve Policy/Maintenance 1.0 Objective: 1.1 To Maintain Pressure Safety Valves And Ensure That No Two Safety Valves Are Blocked In On The Same System At The Same Time Leaving The System Unprotected.

Ethanolamines/Glycol Ethers Tier 3 Policy Section: Issue No.: Original Date: Date: Title: References: 2000 1.1 04-14-94 Author: Tony Grant 12-29-95 Quick Disconnects And Bleeds Glossary Of Equipment Identification (Text #114) And Tier 3 Section 1713 Use Of Flexible Hoses 2000 Quick Disconnects And Bleeds: 1.0 objective: 1.1 To clearly define the plant's position and policy with respect to the use of flexible hoses and the safe handling of these hoses to ensure the safety of our personnel. 2.0 Responsibility: 2.1 It is the responsibility of plant supervision to enforce this policy. 2.2 It is the responsibility of plant personnel to adhere to this policy at all times. 3.0 Policy: 3.1 Due to two (2) recent incidents and other incidents in the past, we felt it necessary to issue a plant policy covering the use of flexible hoses with quick disconnect couplings and bleeds that positively relieve the pressure on the hose prior to attempting the disconnect.

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NUTTER, McCLENNEN & FISH ONE INTERNATIONAL PLACE BOSTON, MASSACHUSETTS 02110-2699 TELEPHONE. 617439-2000 FACSIMILE- 617973-9748 DIRECT DIAL NUMBER. (617)439-2382 May 6, 1992 18371-1 VIA FACSIMILE & U.S.

NUTTER, McCLENNEN & FISH ONE INTERNATIONAL PLACE BOSTON, MASSACHUSETTS 02110-2699 TELEPHONE: 617 439-2000 FACSIMILE: 617 973-9748 RY TELECOPY and P.S.

ISSA/ CHAMBER OF MINES CONFERENCE "Mines and Quarries: Prevention of Occupational Injury and Disease" 19-21 May 2003 Respirable Dust Management in Deep Level South African Gold Mines By Des Wrigley and Kobus Dekker (AngloGold) Synopsis The paper describes a dust risk assessment and management methodology for underground mines that was adopted to facilitate the implementation of a process used to control, minimise and ultimately to eliminate the associated health risk to which employees may be exposed.

Foundry control guidance sheet FD03 Foundry fume when ladle pouring Control approach R Respiratory protective equipment FD03 This guidance sheet is for employers to help them comply with the requirements of the Control of Substances Hazardous to Health Regulations 2002 (COSHH) by controlling exposure to chemicals and protecting workers' health.