3M Larry R.

* 6ft Aazi6_ ior*> EPA / SPI FMG Meeting January 30, 2002 Agenda Introduction Toxicology/PK Program Studies underway Progress Time line r-o cr-i cr O -n c\n ro r ,3 C.O ' rn Environmental Effects/Fate Testing program Environmental distribution Summary I PROJECT SUMMARY REF: APFO - 2 SPONSOR APME PTFE Committee Members and APFO Suppliers (Asahi Glass, DuPont, Dyneon, Daikin, Ausimont, Solvay, AtoFina 3M, Miteni) CHEMICAL Ammonium Perfluoro-octanoate (APFO - FC143) STUDY Preliminary 4 week oral toxicity study in Cynomolgus monkeys. 6 month oral toxicity study in Cynomolgus monkeys to include an additional 13 week recovery period .

iff Larry R.

3M Medical Department Corporate Toxicology 3M Center, Building 220-2E-02 St.

/V P Ce: R.

ffi'ZS. _ 13 II UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460 A P R 1 5 2003 M "O O ro ZS3 TO "O m ~oo -irn ~zxo O p<n oO ro XT MEMORANDUM SUBJECT: Preliminary Risk Assessment of the Developmental Toxicity Associated with PFOA (Perfluorooctanoic Acid) anthitrSaits FROM: Kevin Y.

6; . m-78 A Simple, Conservative Compartmental Model to Relate Ammonium Perfluorooctanoate (APFO) Exposure to Estimates of Perfluorooctanoate (PFO) Blood Levels in Humans Paul M.

3M Specialty Materials 3M Center St Paul, MN 55144-1000 651 733 1110 im r " c -

!

Toxicological Summary AR226-1746 PFOS Dietary Acute Northern Bobwhite Study Test Substance: Perfluorooctanesulfonate (PFOS) Structure: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, potassium salt, CAS# 2795-39-3 Remarks: The test substance is a white powder (3M lot #217).

PFOS: A REPRODUCTION STUDY WITH THE NORTHERN BOBWHITE FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

SRJPTT-6295.8, T-6316,4, T-6868.2, T-7071.1, T-7132.1 0T15-B 3M MEDICAL DEPARTMENT, CORPORATE TOXICOLOGY T-6295), N-ethyl perfluorooctanesulfonamido ethanol (N-EtFOSE, T-6316), N-Ethyl perfluorooctanesuifonamide (N -ItFO SA , T-6868), Perflu orooctan esu Ifonamido acetate (FOSAA, T-7071), and/or Perfluorooctanesulfonam ide (FOSA , T-7132) o f in Rats and Guinea Pigs following O ral dosing.

'wf 3M Specialty Materials FYI-00-001378 3M Center St.

AR226-2160 C hris E S hoop 07/12/2001 01:17 P M _____________ __ ___________________ To: cc: Subject: Robert F Pinchot/DEV/AE/DuPont@ DuPont, Debbie J Wlulrdoney/AE/DuPont@DuPont David M Rurak/AE/DuPont@DuPont, H David Ramsey/SE/DuPont@DuPont, Stephen J Gissy/AE/DuPont@DuPont, Robert L Ritchey/CL/DuPont@DuPont, John J Mentink/CL/DuPont@DuPont, Bernard J Reilly/AE/DuPont@DuPont, John R Bowman/AE7DuPont@DuPont, Andrea V Malinowski/AE/DuPont@DuPont, Oscar T Garza/AE/DuPont@ DuPont, Maurice Astorga/AE/DuPont@DuPont, Catherine A Barton/AE/DuPont@DuPont Re: Air dispersion modeling strategy 0 Rob / Debbie, Here's a table of the data requested.

AR226-2162 H David Ramsey ' 07/16/2001 11:02 AM To: Dawn D Jackson/CL/DuPont@DuPont, George A Ainsley/SE/DuPont@DuPont cc: Subject: FW: Call From Jesse Flanshaw Three key notes - there are some of us who prefer the State and 1both conduct modeling so it is more independent -------------------------------Forwarded by H David Ramsey/SE/DuPont on 07/16/2001 11:01 AM John J Mentink 07/10/2001 08:30:49 AM To: H David Ramsey/AE/DuPont@DuPont cc: Subject: FW: Call From Jesse Hanshaw This is the note originally issued by Chris Shoop.