Document qaOd6B49rgE2NvL2VG3m0k3Rk

p= BE $Z--0Q3309//--1/3 78 A am DuPont Haskell Laboratory MR AR 216 _ 102g i-- E ewan ot ie ne 53ca30 GDierreacltdorL,.AKpeplnineeddyToxicology DP.uOP.onBtoxHa5s0kell Laboratory Elkton Road NPheownaer:k,(3D0e2l)aw3a6r6e-521599714-0050 FYI-90-801378 n" = Z=oaapE VIA FEDERAL EXPRESS i RDoocoummeGn9t9CEoansttroTlowOeffricAeT(T7N4:07)FYI - Office of Pollution Prevention and Toxics 4U0.1S.MEnSvtirreoctn,meSnWta.l Protection Agency Washington, D.C. 20460-0001 8501000001 Dear Sie/Madam: - evLoonons March 8, 2001 Pro ru O@TEIRS Ne 077 "This leter is in reply to Richard HL Hefters eter dated February 14, 2001 to me concerning the above-referenced FYI submission. TprhoeviidnefdorvmoaltuinotnarpirloyvtiodeEdPiAn tinheeJsapnounasrey f25o,42r0e0q1uesatndfrJoumneMr2.3,C2h0ar0l0essubAmuiesrsfioornsexwpaossure and use information from DuPont percaining to the substance in issue. The blood serum test resuits reflect exposure data. No adverse health effects associated with this substance have been found among exposed employees. It is furthernoted that studies submitted by = thheeat3hMefCfoemtpsaansys,ocwihatiecdh wiistthhethmiasnsuufbascttaunrceerhoafvethebeseunbsftoaunncde,aamlosnogcsotncilsuedxeptohsaetdno 55 S29Ex `employees (see 3M SEHQ-0200-14596. dated January 28, 2000). Those studies, cither _ += themselves or through reference to other studies published in the open scientific EOF literature, report that this substance is known to be found in human blood serum of @ employees exposed to the substance' 3s PSlaente. aJ,)GOicclulpa.ndMedF.DM1a9n9d3e:l35J9S5M0o.r9a5li(t0yGAimlolnagnEFmDp,loMyaenedselof15.PeSfelruuomnoPoecratnrooioecAicniodiPcraodcsd inodn arnt iiom \ te sn ' =. sFYaLOrIc0L2O0L0Y1TS Page2 Per EPA's June 1991 TSCA Section 8() Reporting Guide, it is provided that "In deciding whether information is `substantial risk" information, one must consider 1) the seriousness of the adverse effect, and 2) the fact or probability of the effect's occurrence." As stated above, no adverse health effects associated with this substance have been found among exposed employees. In the absence of an adverse effect, the: information was deemed to not meet EPA TSCA Section 8(e) reporting criteria In addition, per the 1991 TSCA Section 8(e) Reporting Guide, information need not be submitted if it is published in the open scientific literature. As referenced above, prior published studies have reported that this substance is present in the blood serum of workers exposed to the substance. Also, in 1980, it was reported in the American Industrial Hygiene Association Journal that perfluorooctanoate anion was found in the binlfooordmoaftiwoonrkpreorvsiedxepdoisnetdhetoDaumPmonotnisuubmmipsersfilounosroioscntoatnoiantdei'c.atiTvheeofblionofdorsmeartuiomn not known to the Agency. It is consistent with information already published in the open scientific literature and as such, was deemed to not meet the criteria for TSCA section 8(e) reporting. Please contact me directly if you need further clarification or wish to discuss this matter in more detail Very tly yours, Gerald Kennedy HMeepda.ti1c99E6n:z2y9m:e56s0,-5L3i6p5o:p(ro)teOilnss,enanGdWC,hoGlielsltielraonld:FAD,StBuudrlyeowf OMcMc.upBautrironsaJlMy,ExMpaonsdeedl MJeS,n.MaAnmd.el1.JHn.d An EPaprifdleumoirooloocgtiacnoIincveAsctki.gatJi.onOocfcuRpe.prEondvu.ctMievde.H1o9r9m8o:n40e:s61in4-M6e22n with Occupational Exposure to P*rUebleilmiFnAa,rySRoerpeonrst.onASmDe,riRcoaanchI,ndDuEs.triHaelaHlytgiSetnateusAsosfPocliaanttioWnoJrokuernrasl.Ex1p9o8s0e:4d1t:o58F4i-u5o8o9c.hemicals a L