GLOSSARY Chromosomal Aberrations: All types of changes in chromosome structure and chromosome number; Chromosome-type Aberrations: Structural chromosome changes in which both chromatids of the chromosome are involved, including isochromatid gaps, breaks, fragments, minutes, and dicentrics; Chromatid-type Aberrations: Chromosome structural changes in which only a single chromatid of the chromosome is involved, including chromatid gaps, breaks, and exchanges; Aneuploidy: Numerical chromosome changes, including the loss and/or gain of individual chromosomes in mitosis or meiosis leading to the formation of nuclei with hypoploid and/or hyperploid chromosome numbers, and the loss or gain of whole chromosome sets; Polyploidy: The gain of one or more complete chromosome sets in diploid somatic cells, including triploidy, tetraploidy and pentaploidy etc.

3M Medical Department Study: T6316.1 3M Medical Department Study: T-6316.1 Analytical Report: FACT-TOX-001 LRN-U2103 Analytical Report: FACLTRTNO-UX2-010013 Study Title 104-Week Dietary Carcinogenicity Study with Narrow Range (98.1%) N-Ethyl Perfluorooctanesulfonamido Ethanol in Rats Analytical Laboratory Report Title Determination of the Presence and Concentration of PFOS, PFOSA, PFOSAA, EtFOSE-OH, M556, and PFOSEA in Serum and Liver Samples of Crl:CD(SD) IGS BR Rats Exposed to N-Ethyl Perfluorooctanesulfonamido Ethanol Data Requirement Not Applicable Author 3M Environmental Laboratory Study Completion Date June 06, 2001 Performing Laboratories Liver and Serum Analyses 3M Environmental Laboratory Building 2-3E-09, 935 Bush Avenue St.

3M Medical Department Study: T6316.1 3M Medical Department Study: T-6316.1 Analytical Report: FACT-TOX-001 LRN-U2103 Analytical Report: FACLTRTNO-UX2-010013 Study Title 104-Week Dietary Carcinogenicity Study with Narrow Range (98.1%) N-Ethyl Perfluorooctanesulfonamido Ethanol in Rats Analytical Laboratory Report Title Determination of the Presence and Concentration of PFOS, PFOSA, PFOSAA, EtFOSE-OH, M556, and PFOSEA in Serum and Liver Samples of Crl:CD(SD) IGS BR Rats Exposed to N-Ethyl Perfluorooctanesulfonamido Ethanol Data Requirement Not Applicable Author 3M Environmental Laboratory Study Completion Date June 06, 2001 Performing Laboratories Liver and Serum Analyses 3M Environmental Laboratory Building 2-3E-09, 935 Bush Avenue St.

Case Diagnosis: JCML clinical lab operating at 100% capacity, processing 30% more cases than anticipated with 99+% concordance between primary diagnosis & secondary pathology review.

Wampler, or the Eagle richer Lead Company has been in their flew Jersey plant for the past several seeks trying to introduce safety measures and he Cam* back markedly impressed with tha medical inspection here and I gathered from his remarks both to me and to the safety engineers at the meeting last Wednesday that it is his opinion and recommendation that If they would have the same nodical efficiency In their Inspection* as we have here that they would oeae to have much eg the trouble that they are having, he laid aphasia at the safety meeting eu the fact that their lack or supervision of manpower has permitted Industrial diseases to creep Into the ccm- pensatlon lave and the two things he particularly mentioned vase the fifgjg polaoniug gad expectation of asbestos legislation.

Vol. 10, 831 838, August 2001 Cancer Epidemiology, Biomarkers & Prevention 831 Protein Adducts of 1,4-Benzoquinone and Benzene Oxide among Smokers and Nonsmokers Exposed to Benzene in China1 Karen Yeowell-O'Connell, Nathaniel Rothman, Suramya Waidyanatha, Martyn T.

p' 3M /\-(tHP.6~ $S~7 3M ENVIRONMENTAL LABORATORY PROJECT NO.EOS-0442 Analytical Report Definitive Study: Quantitative Screening of Commercial Lots of Human Serum Obtained in 2004 for Endogenous Fluorochemicals Using Solid Phase Extraction and Liquid Chromatography/Tandem Mass Spectrometry Laboratory Request Number: E05-0442 Testing Laboratory 3M Environmental Health and Safety Operations 3M Environmental Laboratory 3M Environmental Laboratory Project Lead Mark E.

The severity of neuroblastoma ranges from asymptom- atic tumors that spontaneously regress to rapidly progressing tumors that respond poorly to aggressive treat- ment and often lead to death.* Clinical and biological subgroups of neuroblastoma have been characterized by the age at diagnosis, tumor stage at diagnosis, and spe- cific genetic alterations such as MYCN oncogene am- p l i f i ~ a t i o nT.

Reed, PhD Staff Vice President Environmental Technology and Safety Services B ES T CO PY AVAILABLE: 89050000598 9 0 s 000 0 5 9 8 I 3M ENVIRONMENTAL LABORATORY PRO JEC T NO.E05-0120 NO TSCA CBI Analytical Report Revised August 12, 2005 Initial Quantitative Screening of Commercial Lots of Human Serum Obtained in 2004 for Endogenous Fluorochemicals Using Protein Precipitation and Liquid Chromatography/Tandem Mass Spectrometry Laboratory Request Number E05-0120 Testing Laboratory 3M Environmental Health and Safety Operations 3M Environmental Laboratory 3M Environmental Laboratory Project Lead Mark E .

-_-- oDwupree1s530:2 Study Tide Ammonium Perfluorooctanoate: Age Effect on the PFOA Plasma Concentration in Post-Weaning Rats Following Oral Gavage "TEST GUIDELINES: None applicable AUTHOR: Paul M.

Reed, PhD Staff Vice President Environmental Technology and Safety Services B ES T CO PY AVAILABLE: 89050000598 9 0 s 000 0 5 9 8 I 3M ENVIRONMENTAL LABORATORY PRO JEC T NO.E05-0120 NO TSCA CBI Analytical Report Revised August 12, 2005 Initial Quantitative Screening of Commercial Lots of Human Serum Obtained in 2004 for Endogenous Fluorochemicals Using Protein Precipitation and Liquid Chromatography/Tandem Mass Spectrometry Laboratory Request Number E05-0120 Testing Laboratory 3M Environmental Health and Safety Operations 3M Environmental Laboratory 3M Environmental Laboratory Project Lead Mark E .

AR226-2817 DuPont-15372 TRADE SECRET Study Title H-24921, H-26313, and H-26225: Evaluation of the Interference of the Test Substance in the Analysis of Rat Serum Lipids Author: Denise Hoban, B.A, MLT (ASCP) Study Completed on: October 13,2004 Testing Facility: E.I. du Pont de Nemours and Company HaskellSMLaboratory for Health and Environmental Sciences Elkton Road, P.O.

Human Mesothelioma Samples Overexpress Both Cyclooxygenase-2 (COX-2) and Inducible Nitric Oxide Synthase (NOS2): In Vitro Antiproliferative Effects of a COX-2 Inhibitor Aizen Marrogi, Harvey I.

Both " 2 exposure to, and metabolic production of target analytes will lead to artificially long halflife estimations.

AR226-2813 Study Title Ammonium Perfluorooctanoate: Age Effect on the Plasma Concentration in Post-Weaning Rats Following Oral Gavage Author: Xing Han, Ph.D.