Document qkXZmJYYwqrO8161eLgZ5RgrG
Case Diagnosis: JCML clinical lab operating at 100% capacity, processing 30% more cases than anticipated with 99+% concordance between primary diagnosis & secondary pathology review. CDC
Case Accrual: Logistical issues affecting NHL accrual rate have been successfully resolved. All
Exposure Assessment: Exposure Assessment fully operational, and Exposure Re-creation Committee reorganized apart from IPHS. Exposure activities will be highlighted at annual meeting.
External Review Panels: ERP Chair will be chosen at Asilomar, and Ethics panel will resume
Fund Balance at API 1Q04 = $5,193,061 1
General: 2004 report generation went like clockwork, with mininal API time required to generate report
Irons Field Expenses: Total T&E expenses are currently 1% ($15K) over budget and need to be
UCHSC: $874,031 was disbursed in 2004. First-half 2004 total expenses were 100+% (-$1 MM) above
Subcontracts: Total UCHSC Subcontractor expenses were -$800K above projected budget, attibuted
AHS: 2004 expenses include both 10 & 20 due to timing of new AHS contract. Labor costs high due
(J) length of time in Shanghai, but travel savings have kept total expenses 1% ($28K) under budget.
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Fudan University: 30% additional case load, and transfer of CDC & IPHS activities has increased rate
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s:I SRP/ERP: Total expenses 2% ($9K) over budget following 1004 budget adjustment and unanticipated
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Communications (APCO): Low 2004 activity; cummulative variance of 9% under budget
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Outside Legal Council: cummulative variance of 12% under budget
QAlQC: proposal requested from Judy Baldwin, per Technical Committee recommendation.
API Administrative Costs: 10% over budget for the quarter due to high activity associated with
Income detail worksheet: per Technical Committee request, line item added for UCHSC interest.
UCHSC grant requires close monitoring due to large 2Q04 expenses and new case cost structure
API administrative expenses requires close monitoring to contain costs.
Establish new Fudan University and Dr. Ironsfield expense contracts (in progress).
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s:I Oversight Committee Acceptance: () Posted to website:
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SH ELL-MCCLU RG-056524
Benzene Health Research Consortium 2004 Financial Report Overview
Case Diagnosis: JCML clinical lab operating at 100% capacity, processing 30% more cases than anticipated with 99+% concordance between primary diagnosis & secondary pathology review. CDC
Case Accrual: Logistical issues affecting NHL accrual rate have been successfully resolved. All
Exposure Assessment: Exposure Assessment fully operational, and Exposure Re-creation Committee reorganized apart from IPHS. Exposure activities will be highlighted at annual meeting.
External Review Panels: ERP Chair will be chosen at Asilomar, and Ethics panel will resume
Fund Balance at API 1Q04 = $5,193,061 1
General: 2004 report generation went like clockwork, with mininal API time required to general report
Irons Field Expenses: Total T&E expenses are currently 1% ($15K) over budget and need to be
UCHSC: $874,031 was disbursed in 2004. First-half 2004 total expenses were 100+% (-$1 MM) above
Subcontracts: Total UCHSC Subcontractor expenses were -$800K above projected budget, attibuted
AHS: 2004 expenses include both 10 & 20 due to timing of new AHS contract. Labor costs high due
(J) length of time in Shanghai, but travel savings have kept total expenses 1% ($28K) under budget.
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Fudan University: 30% additional case load, and transfer of CDC & IPHS activities has increased rate
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s:I SRP/ERP: Total expenses 2% ($9K) over budget following 1004 budget adjustment and unanticipated
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Communications (APCO): Low 2004 activity; cummulative variance of 9% under budget
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Benzene Health Research Consortium 2Q04 Financial Report Overview
Outside Legal Council: cummulative variance of 12% under budget
QAlQC: proposal requested from Judy Baldwin, per Technical Committee recommendation.
API Administrative Costs: 10% over budget for the quarter due to high activity associated with
Income detail worksheet: per Technical Committee request, line item added for UCHSC interest.
UCHSC grant requires close monitoring due to large 2Q04 expenses and new case cost structure
API administrative expenses requires close monitoring to contain costs.
Establish new Fudan University and Dr. Ironsfield expense contracts (in progress).
(J)
I Need to reconcile UCHSC statement - they have a $105 error.
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s:I Oversight Committee Acceptance: () Posted to website: ()
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LT 8/6/04 BJ 7/26/04
Benzene Health Research Consortium 2Q04 Financial Report Overview
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Item AHScienc es CaseControl Study DP&ME Studies (UCHSC) Irons(T & E) Fudan University
Total Research Costs Scientific Review Panel Ethics Review Panel
Benzene Health Research Consortium
Approved Program Budget
Approved Original Cost Revised Cost
2Q04 Financial R- .........
Unapproved
Approved
Changes not
Approved
Estimate
Estimate approved (June 11 NOV 03 OC 21 APR 04 OC
(Jan. 2001) (Dec. 2001)
2003)
mtg
mtg
$1,595,000 $2,283,095
$2,283,095
$2,283,095
$2,283,095
$13,665,017 $15,258,017
$1,253,428 $1,253,428
$165,700
$190,555
$16,679,145 $18,985,095
$15,258,000
$1,597,273
$661,000 $19,799,368
$14,508,000
$1,413,428
$230,000 $18,434,523
$14,508,000
$1,413,428
$230,000 $18,434,523
$648,000
$551,736
$300,000
$300,000
$216,000
$192,000
$64,000
$64,000
External
Pathology
&
Cytogenet
ics
Workgrou
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s:I Monies
() Outside
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$450,000 $500,000
$130,000 $994,000
$0
$500,000
$0 $743,736
$0
$100,576
$0 $364,000
$0
$100,000
$0 $364,000
$0
$100,000
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Public Affairs QAlQC Activities UCHSC Interest contingency
Miscellaneous Costs Subtotal API Admin. GRAND TOTAL
Benzene Health Research Consortium Approved Program Budget 2Q04 Financial Report
$1,000,000 $1,000,000
$960,600
$550,000
$550,000
$225,000
$190,855 $1,690,855 $18,820,000
$941,000
$0 $1,725,000 $21,704,095 $1,085,205
$100,000
$0 $1,161,176 $21,704,280 $1,085,019
$100,000 ($100,000)
$390,272 $1,040,272 $19,838,795 $1,245,205
$100,000 $0
$290,272 $1,040,272 $19,838,795 $1,245,205
$19,761,000 $22,789,300
$22,789,299 $21,084,000 $21,084,000
Notes by API
Notes/As sumption s for Dec. 2001 revised budget:
- The total research costs have changed as a result of - Panel costs assume that there will be only one face-to-
face meeting for each panel each year.
LT 7/19/04
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Cost Centers Income
Benzene Health Research Consortium Executive Summary
2Q04 Financial Report
Project #
Inception Thru
December 2003
Actuals
Actuals Jan - June
2004
$ 15,257,275 $ 1,492,621
$ 16,749,895
Cumulative Actuals Inception
Thru 2Q04
$ 16,749,895
Budget (actual + projected
2004
2005 $1,461,334
Cost Centers
UCHSC* Irons-Field Expense* Applied Health Sciences Fudan University
X8105 X8106 X8107 X8108
Scientific & Ethics Panels X8109
Communications
X8103
Outside Legal Counsel X8104
QAlQC Support
X8110
API Administrative
X8100
Contingency
Total Expenses
Fund Balance
7,515,759 539,486 951,892 31,981
82,854 290,866
33,208
594,670 101,473
874,031 189,320 168,623
27,755
12,529 790
3,360
138,238
$ 10,142,189 $ 1,414,645
$ 5,115,086 $ 77,975
8,389,790 728,806
1,120,515 59,736
8,389,790 728,806
1,120,515 59,736
95,383 291,656 36,567
95,383 291,656 36,567
732,908 101,473
732,908 101,473
$ 11,556,834 $ 11,556,834 ~9~1~.9R1 **
874,030 111,016 196,681
14,575
1,748,060 222,032 441,867 29,148
76,750 30,000 8,349 12,500 137,100
79,250 60,000 16,698 25,000 123,330 188,799
$ 1,461,001
$ 2,934,184
::::::I~!1U~91 r:::::::::::::::::::::$::I~gl;g'-m:r:rrmr
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**$2,166,979 of fund balance
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Benzene Health Research Consortium Executive Summary
2Q04 Financial Report
income &expenses)
2006 $1,461,333
2007 $1,461,333
Projected Expenses
Program Budget
I I$ 21,133,895 $ 21,084,000
1,748,060 222,030 449,985 29,148
1,748,060 222,028 45,833 29,148
14,508,000 1,505,912 2,254,880 161,755
14,508,000 1,413,428 2,283,095 230,000
74,250 60,000 16,698 25,000 123,200
$ 2,748,371
47,396 79,135 16,698 25,000 123,200
$ 2,336,498
373,029
364,000
520,791
550,000
95,010
100,000
87,500
100,000
1,239,738 1,245,205
290,272
290,272
'..._ _ _ _..1
I I$ 21,036,887 $ 21,084,000
::::::::::::::::::::t!11;:1@1::::::: :::r::::::::::::::::::::::t!~.::
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sponsors
$16,500,000
()
2001 seed
$15,000
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MAP contrib. API interest UCHSC interest
TOTAL
$200,000 $34,895
$0
$16,749,895
Benzene Health Research Consortium Executive Summary
2Q04 Financial Report
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Benzene Health Research Consortium Case Accrual 2Q04 Financial Report
variance = cases "case predictions based on'hlstorlcal estimates; these are not target numbers of cases required for study completion LT7/19/04 BJ 7/26/04
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Benzene Health Research Consortium Case Accrual 2Q04 Financial Report
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Benzene Health Research Consortium Cash Flow Statement 2Q04 Financial Report
:f!gM,e~r~!iM!WM~~:rrrr
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LT 7/29/04
NOTE,! $$JQ$'~Qjlin bank at API
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Benzene Health Research Consortium Cash Flow Statement 2Q04 Financial Report
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Cost Centers
Benzene Health Research Consortium Program Expense Summary 2Q04 Financial Report
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r-------------~------~----------~~~----------~,--~~~~,
Cost Centers
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Benzene Health Research Consortium Program Expense Summary 2Q04 Financial Report
LT 7/29/04
Amt.At UCHSC & Irons Field exp. Bank acct
$11,556,834 $11 ,178,458
$378,376
$77,182 In Irons' field exp bank acct as of 6/30104
Total as of $378,376 6/30104
API disbursed by period (includes pre-payments
for UCHSC & Irons Field)
24,600
1,577,811 7,652,678
318,759
258,097
310,244
66,019 1,348,626
IT 874,030
IT 874,030
IT 874,030
IT 874,030
IT
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r-------------~------~----------~~~----------~,--~~~~,
Cost Centers
LT 7/29/04
API disbursed by period (includes pre-payments
for UCHSC & Irons Field)
874,030
IT 874,030
IT 874,030
16,921,638
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Benzene Health Research Consortium UCHSC Grant 2Q04 Financial Report
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Benzene Health Research Consortium UCHSC Grant 2Q04 Financial Report
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Cost Centers
LT 8/6/04
BJ 8/04/04
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Am!. paid UCHSCto date:
Am!. expensed to date: Am!. In UCHSC bank acct:
Benzene Health Research Consortium UCHSC Grant 2Q04 Financial Report
3rd Otr
4th Otr
3rd Otr
4th Otr
1st Otr
2nd Otr
3rd Otr
4th Otr
(Adjusted 4003: $48,839 attributed to UCHSC in 3003 Report has been reallocated to Contingency: $25,000 preconsortium gran tin 2001; $3,600 for IRB Review in 2002; $20,239 for EMBSI "feasibility $8,389,790 study" in 2002)
(Adjusted 4003: 2001 costs had been double expensed in 2002 column; ($523,807) adjusment $8,088,596 made in 4003)
$301,194
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UCHSC (x81 05) Cost Centers
Benzene Health Research Consortium UCHSC Grant 2Q04 Financial Report
2006
2nd Olr.
3r.d Olr.
4lh Olr.
2007
2nd Olr.
3r.d Olr.
4lh Olr.
LT 8/6/04
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LT 8/6/04 BJ 8/04/04
"Actual expenses" from UC Office of Grants & Contracts report.
Benzene Health Research Consortium UCHSC Subcontract 2Q04 Financial Report
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Cost Centers
1st & 2nd
Benzene Health Research Consortium Irons Field Expenses 2Q04 Financial Report
4Q03 ADJUSTME NT2001/2002 expense underrecord ed; -0$114,289 adjustment
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$728,806 of 06/30104
Amt Irons
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$651,624
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Cost Centers
2nd Olr.
3r.d Olr.
4lh Olr.
Benzene Health Research Consortium Irons Field Expenses 2Q04 Financial Report
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Amt. In Irons bank acct:
$77,182
Benzene Health Research Consortium Irons Field Expenses 2Q04 Financial Report
3rd Otr 4th Otr 1st Otr 2nd Otr 3rd Otr 4th Otr
1st Otr
2nd Otr
3rd Otr
4th Otr
1st Otr
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IRONS T&E (X81 06) Cost Centers
LT 7/19/04 BJ 7/22104
2007
2nd OIL
3rd OIL
4lh OIL
Benzene Health Research Consortium Irons Field Expenses 2Q04 Financial Report
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Cost Centers
1st & 2nd
Benzene Health Research Consortium AHS 2Q04 Financial Report
LT 7/19/04 BJ 7/14/04
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Adjustment: expense reduced by $52,634; transferred to contingency since these were preconsortia expenses
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Cost Centers
2nd Ole.
3rd Ole.
4lh Ole.
Benzene Health Research Consortium AHS 2Q04 Financial Report
LT 7/19/04 BJ 7/14/04
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Benzene Health Research Consortium Fudan 2Q04 Financial Report
LT 7/19/04 BJ 7/1104
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Benzene Health Research Consortium Fudan 2Q04 Financial Report
LT 7/19/04 BJ 7/1104
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Benzene Health Research Consortium
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Benzene Health Research Consortium SRP + ERP 2Q04 Financial Report
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. . .:~i#.ri\MM~#li~~:#'ii~~W~WW~:iii@:@iiii:iiiH~\#'@?(::::::::::.:
LT 7/19/04 BJ 7/22104
1Q04 budget ajustments to zero our variance to develop more useful budget projections for remainder of program. Change approved by OC at 4/21/04 meeting.
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Benzene Health Research Consortium SRP + ERP 2Q04 Financial Report
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LT 7/19/04 BJ 7/22104
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Cost Centers
Benzene Health Research Consortium Communications 2Q04 Financial Report
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Cost Centers
Benzene Health Research Consortium Communications 2Q04 Financial Report
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* budget adjustment to lower program budget from $500K to $1 OOK, as approved by OC on 11 III 103
LT 7/19/04 RT 7/16/2004
Benzene Health Research Consortium Legal 2Q04 Financial Report
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* budget adjustment to lower program budget from $500K to $1 OOK, as approved by OC on 11 III 103
LT 7/19/04 RT 7/16/2004
Benzene Health Research Consortium Legal 2Q04 Financial Report
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Benzene Health Research Consortium QA-QC 2Q04 Financial Report
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Benzene Health Research Consortium QA-QC 2Q04 Financial Report
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Cost Centers
Benzene Health Research Consortium API Administration 2Q04 Financial Report
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T&E and Other $15K for Annual Meeting (3rd Quarter)
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Cost Centers
Benzene Health Research Consortium API Administration 2Q04 Financial Report
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T&E and Other $15K for Annual Meeting (3rd Quarter)
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funds for consultant
Benzene Health Research Consortium API Administration 2Q04 Financial Report
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2006
2nd Olr.
3rd Olr.
Benzene Health Research Consortium API Administration 2Q04 Financial Report
4lh Olr.
1s101r.
2007
2nd Olr.
3rd Olr.
4lh Olr.
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Benzene Health Research Consortium Contingency Fund 2Q04 Financial Report
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4Q03 Adjustment - per Technical Committee, transfer $48,839 from UCHSC expense detail to contingency because expenses not part of UCHSC grant budget:
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Benzene Health Research Consortium Contingency Fund 2Q04 Financial Report
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Benzene Health Research Consortium Contingency Fund 2Q04 Financial Report
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Benzene Health Research Consortium Contingency Fund 2Q04 Financial Report
J-\n0 - t:Xpt:II:::;t;:: lIdll:::;It:1 VI
$52,634 from AHS expense detail to contingency because expenses not part of AHS full study budget
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UCHSC; seed money exhausted (API & sponsor), expense not included in final grant cost estimate L. ".50UU ltil:) Tees IO U or lJU (this will be a yearly fee, since IRB must review at least once per year) j. LUUL inVOice (~LU,Lj8) trom EMBSI for final feasibility study work (very late billing to API)
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LT 7/19/04 RT 7/1 6/2004
Benzene Health Research Consortium Income 2Q04 Financial Reoort
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Benzene Health Research Consortium
Income 2Q04 Financial Reoort
2007
i ..........
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Company Name BP
(Seed Money)
$15,000 $22,500
Inv, # 522922 528453
Date Paid 8-Nov-00 19-Jun-01
Benzene Health Research Consortium
Sponsor Invoice Detail 2Q04 Financial Report
2001
2002
3rd - 4th Qtr,
22-Aug-01 $768,941
Inv, # Date Paid 529301 4-0ct-01
9-Jan-02 $806,441
Inv,# Date Paid 532263 22-Feb-02
27-Aug-02 $1,344,069
$112,008
Inv, # 535033
Date Paid 11-0ct-02 2-0ct-02
2003
23-Sep-03
Inv,# Date Paid
$1,431,041.00 544951 4-0ec-03
ChevronTexaco
$15,000 522923 7-Nov-00
$522,627 529302 9-0ct-01 $537,627 532244 22-Feb-02 $896,046 535034 5-Nov-02 $1,028,700.00 544953 19-Nov-03
ConocoPhillips
$15,000 522924 31-0ct-00 $7,500 528574 31-Jul-01
$246,314 529309 17-Sep-01 $268,814 532245 16-Jan-02 $448,023 535035 26-Sep-02
$514,349.00 544954 27-0ct-03
ExxonMobii
$0 523540
$1,612,882 $806,441 $806,441
532246
23-Jan-02 11-Feb-02
$1,344,069 535036
13-Sep-02
$1,543,049.00 $771 ,524.50 $771 ,524.50
544956
3-0ct-03 22-Mar-04
Shell Marathon
$15,000 523054 24-0ct-00 $15,000 528333 15-May-01
$15,000 528541 14-Aug-01
$507,627 529305 25-Sep-01
$537,627 532247 7-Feb-02
$896,046 $448,023 $448,023
535037
25-Sep-02 10-Feb-03
Marathon Ashland
Marathon Oil
$1,028,700.00 544958 $514,350 $514,350 $150,000 548582 $50,000 548581
28 Oct 03 14 Jan 04 20-Jan-04 3-Feb-04
Total LT 7/19/04
$120,000
$2,045,509
$5,376,273
$5,936,307
I
$8,317,588,00
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Benzene Health Research Consortium Sponsor Invoice Detail 2Q04 Financial Report
TOTAL $4,500,000 $3,000,000 $1,500,000
$4,500,000
$3,000,000 $215,000
$16,715,000
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Benzene Health Research Consortium Sponsor Payment Detail 2Q04 Financial Report
3Q03
$-
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RT 5/5/04 LT 7/19/0 4
Benzene Health Research Consortium Sponsor Payment Detail 2Q04 Financial Report
(note - does not include interst income)
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Company
Date Paid Amount
American Petroleum Institute
1/17/2003 $
(I am trying to get this $1.09
1.09 I emoved from the books)
BP International Limited
11/8/2000 $ 15,000.00
BP International Ltd
6/19/2001 $ 22,500.00
BP p.Lc.
10/4/2001 $ 768,941.00
BP p.Lc.
2/22/2002 $ 806,441.00
BP p.Lc. BP p.Lc. BP p.Lc.
10/2/2002 $ 112,008.00 10/11/2002 $ 1,344,069.00
12/4/2003 $ 1,431,041.00
$
BP Total 4,500,000.00
Chev ronTexaco Chev ronTexaco Chev ronTexaco Chev ronTexaco Chev ronTexaco
11/7/2000 $ 10/9/2001 $ 2/22/2002 $ 11/5/2002 $ 11/19/2003 $
15,000.00 522,627.00 537,627.00 896,046.00 1,028,700.00
ChevronTexaco Total $ 3,000,000.00
ConocoPhillips
10/31/2000 $ 15,000.00
ConocoPhillips
7/31/2001 $
7,500.00
ConocoPhillips
9/17/2001 $ 246,314.00
ConocoPhillips
1/16/2002 $ 268,814.00
ConocoPhillips ConocoPhillips
9/26/2002 $ 448,023.00
ConocoPhillips Total
10/27/2003 $ 514,349.00 $
1,500,000.00
ExxonMobil Research and Engineering 1/23/2002 $ 806,441.00
ExxonMobil Research and Engineering ExxonMobil
2/11/2002 $ 806,441.00 9/13/2002 $ 1,344,069.00
ExxonMobil ExxonMobil
10/3/2003 $ 771,524.50 3/22/2004 $ 771,524.50 $
ExxonMobil Total 4,500,000.00
Marathon Ashland Petroleum, LLC.
8/14/2001 $ 15,000.00
Marathon Ashland Petroleum, LLC. Marathon Oil Company
1/20/2004 $ 150,000.00 Marathon Ashland Total
2/3/2004 $ 50,000.00 $
215,000.00
Shell Chem ical
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10/24/2000 $ 5/15/2001 $ 9/25/2001 $ 2/7/2002 $ 9/25/2002 $ 2/10/2003 $
10/28/2003 $ 1/13/2004 $
15,000.00 15,000.00 507,627.00 537,627.00 448,023.00 448,023.00 514,350.00 514,350.00
Shell Chem ical Total $ 3,000,000.00
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SH ELL-MCCLU RG-056586
BHRC OVERSIGHT COMMITTEE & COMMITTEE CHAIR CALL ACTION ITEM TABLE Last updated 8/4/04
Budget - Document with UCHSC that API requested interest for 2001,2002 and 2003 unspent funds and was denied, indicating that consortium still feels that it is owed this interest incomesend letter to UCHSC (4/21/04 & 6/21 Outreach - find out relevant professional meeting dates locations and presentation/abstract deadlines via internet (4/21/04 & 6/21/04 Review organizations & contacts with Matt (6/21/04)
Budget - Pursue possibility of SHS clinical laboratory income beina used to defrav studv costs Outreach - 2004 Benzene International Symposium
o review attendee list for potential follow-up o venue for USEPA, EU and German MAK update o get extra copies of proceedings (Chem. BioI.
Interaction special issue and individual SHS reprints)
J. Wagner & B. Jarnot
M. Todd/L. Russo
Outreach Contacts J. Wagner
Technical Committee
Outreach - outreach coordination, make sure circulate
summaries as contacts are made
2004 Annual Meeting - Develop a robust closing session for the 2004 mootinn
M.Todd P. Clegg
Drafted
Due 6/30/04
ongoing In progress
Updates will be posted to readsheet on website
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BHRC OVERSIGHT COMMITTEE & COMMITTEE CHAIR CALL ACTION ITEM TABLE Last updated 8/4/04
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BHRC OVERSIGHT COMMITTEE & COMMITTEE CHAIR CALL ACTION ITEM TABLE Last updated 8/4/04
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BHRC OVERSIGHT COMMITTEE & COMMITTEE CHAIR CALL ACTION ITEM TABLE Last updated 8/4/04
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Draft 6/2/04
BHRC Regulatory & Technical Outreach Plan
Action
Outcome/Comments
Patrick & I Set up meeting with EPA
Stuart
contacts (probably in DC)
3004
I Pending
Technical Contact Jerry Rice for advice on Committee how to contact
4004
I Pending
Email to organizers of
International Benzene
EU Environment DG
Patrick
Symposium (Dr. Greim)
I recommending that they consider I
3004
I Pending
whether EU or other Europe
- lators should be invited.
Contact by phone or in pers
Anticipate attendance at
German MAK
International Benzene
I Symposium, where investigators
4004
I Completed
will be presenting SHS
information
Health Canada (Betty Meeks)
Contact Geoff Granville (Shell
P t B . I Canada) and Roger Keefe
a sy & nan (Imperial Oil) for advice for
3004
Pending
contact
OSHA
Technical Committee
Identify OSHA contact and offer briefing
1/2005
Pending I Need to identify BHRC lead
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ACGIH (Jim Pierce)
Stuart (on TLV committee)
ACGIH is not currently working on benzene; seek opportunity to inform as an FYI
2005
Pending
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Australia
(info@nohsc.gov.au or
_r_ "'="- _"_
BHRCOC members
Pursue company contacts in Australia
2004
Pending
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