ACUTE CONTACT TOXICITY TO TERRESTRIAL INVERTEBRATES (HONEY BEE) TEST SUBSTANCE Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks field: The 3M production lot number was 217.

BACK TO MAIN TOXICITY TO AQUATIC PLANTS (Freshwater Diatom, Navicula pelliculosa) TEST SUBSTANCE_______________________________________ Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: Sample obtained from 3M production lot number 217.

3M General Offices 3M Center St.

M n -IW Benchmark Doses for Liver Tumors in Sprague Dawley Rats fed Perfluorooctane Sulfonic Acid Potassium Salt (PFOS) David W.

3M M edical Department Study: T-6295.22 Analytical Report: FACT-TOX-160 LIMS E00-1668 3M Medical Department Study: T-6295.22 Analytical Report: FACT TOX-160 LIMS E00-1668 Study Title 36> Extended Recovery Study Following a 26-W eek Capsule Toxicity Study (FACT-TO X-030) with Perfluorooctane Sulfonate Acid Potassium Salt (PFOS; T-6295.22) in Cynomolgus Monkeys IIO 3 A nalytical Laboratory Report Title Determination of the Presence and Concentration of PFOS in Serum and Liver Samples of Cynomolgus Monkeys Data Requirem ent Not Applicable A u th o r 3M Environmental Laboratory Study Completion Date May 3, 2002 Performing Laboratories Sera and Liver Analyses Sera and Liver Extractions 3M Environmental Laboratory Building 2-3E-09,935 Bush Avenue St.

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3M Specialty Materials 3M Center St.

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3M Specialty Materials 3M Center St.

Katherine E.

Estrous Cycling and Natural Delivery/Litter Observation Data FI Estrous Cycling Data, From Data Analysis Presented at EPA on August 30,2002" APFO Dose Group (mg/kg/day) 0 1 3 10 30 All 4-Day 14/30 19/29 9/30 15/29 15/30 Cycles 3-5 Day Cycles 24/30 26/29 21/30 25/29 27/30 Cycle Length (Days) 2 3 4 5 6 7 8 Mean Cycle Length (Days) S.D. 1 2 75 18 5 1 2 4.3 0.8 Incidence of Cycle Length Per Group 0 1 80 16 2 1 0 4.2 0.5 5 7 57 32 5 0 1 4.3 0.9 2 5 84 14 3 0 0 4.1 0.6 5 5 86 17 0 0 2 4.1 0.8 Aberrant Cycles Parental > 4 Days Diest. 2 1 14 1 > 3 Days Est. 17 13 15 16 13 FI > 4 Days Diest. 5 3 3 5 3 > 3 Days Est. 25 25 29 11 14 P E M D End in Estrous Distribution of Cycle Status at Start of 21-Day Evaluation Period, FI 14 12 8 10 11 14 6220 15 13 16 13 Distribution Rats in Estrous at End of 21-Day Evaluation Period, FI 13 17 18 19 5 11 2 12 19 Mean Implantations, Liveborn, and Stillborn S.D. per Litter by Group c Parental Litters Implantations 15.3 1.9 15.6 2.1 15.2 2.3 15.6 2.0 15.3 2.0 Liveborn 14.2 2.2 14.2 2.6 13.4 3.6 13.8 3.0 13.4 3.3 Stillborn 0.1 0.3 0.4 1.4 0.2 0.4 0.1 0.4 0.2 0.6 F I Litters Implantations 14.8 3.0 15.8 2.1 14.7 2.8 15.0 2.9 14.5 2.9 Liveborn 13.6 2.9 13.7 2.4 13.8 3.0 13.5 3.1 13.3 2.8 Stillborn 0.2 0.5 0.2 0.5 0.2 0.6 0.2 0.5 0.1 0.2 "Original analysis counted cycles from the day following estrous (or proestrous if diestrus followed proestrous without observation of estrous) to the day following the end of the next estrous.

f l& 2 6 -1 6 f t FFOS: A PILOT REPRODUCTION STUDY WITH THE NORTHERN BOBWHITE FINAL REPORT WILDLIFE INTERNATIONAL, LTD.

TherImmune R esearch C orporation smosso. 3M Corporate Toxicology Building 220-2E-02, 3M Center St.

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