Document QdxEjXdoZ7o85V2861Kw70bL

EEEEEE EAVIRGNAENTAL CONSULTANTS ENVIRONMENTAL COnSULtANTS Ome: Fabruay 17,2008 Date: February 17, 2006 To: Dole Bacon, 3M To: Dale Bacon, 3M From: John Giesy, ENTRIX nc. From: John Giesy, ENTRIX lnc. Ret Follow up to February 2, 2006 meoting rovisod memo) Re: Follow up to Februarf 2, 2006 meeting (revised memo) ENTRIX, Inc_ 1255 Okmos Roec, Seutt101 4295 Okemos Road, Suite i01 eos, Wl e004 Okemos, MI 48864 P5171 1404 P 517.381.1434 Fax 517.391 1495 FAX 517.381.1435 ~So o1I paaimms.wwrriittHiinangtgettoo1 ffuoolllloowrweucuappp.oomnnyoouuurrndrreaecrceesnnattndmmieeneegttiionnfgg tiinnhEEtaaossptitcLLsaanansnsidinngg.Q.ueDDsuburoriinnnsgg ttthhhaaat wmmeeeeretetiinnGggiwewceuedsidsesisdccuuassnssdeeddhessoetvvaeesrrkaasll tt7oh5npay1itcwwwsa.eey.wwHeeePrrreioesadItriwreeeicclclttoeorneddtcattacoopt uuumnnswddyoeirurihtnaadvkleee.rr.sftaPPcnlaeedtainossgen of the topics tof aeddknoonw let me know and questions that were discussed draancytoofnsIn assgned sks need fo if any of the assigned tasks need to be changed in and the tasks be changed in any way. Please contact us with clarification or additional directions. 1. 1. FW Weee fhhaarvveee ccwoonsnffiiwrrmimleeddbotthheattrttahhene ssfttoaanntddaayrrddssYooorruddeeorrfeeddpbbmyye33nMMtiinnsNNaoovvleemmbnbeerrmddaiiddraasrrrinveelaaytt MMmSSaUnU_n.erIi.nn SSopenreryfycutoffuorrrpelnrawonttenffoowlalliololcwwbeiinenggocuuepmpr.ot.avineMMyytfooffranwuuaotlrttidfeaynrwtiyiiroeheullyS.o.hf eI|sjhsuusispatmtlooenssnatttrtarbaarerccivk.kaoolsff K sinc wodi not have & in a more timely manner, it since we did not have a specific plan in place to move forward with studies at that time. w ls were sowed a he eas dove n ha Gt (10 MKD) precuced bong a 10 aQQuueiestsitbiooenn:r:epSSeahotoeuudldtotthhbeelaccihhnrroonniiNccossitOuudbdyyseooffrttvhheee ppAotdtevenentrtasialel Eefffefeeccctttsss CoofofnPPceFFnOOtrSSatooinnonrree(ppNrrOooddAuuEccCtt)iioo?nn Iiinnn he previously conducted sy the experimental design and th fact rat some equocal quail be repeated to obtain a No Observable Adverse Effects Concentration (NOAEC)? In the previously conducted study the experimental design and the fact that some equivocal effects were observed at the least dose in the diet (10 mg/kg) precluded being able to acrely assan a NOAEC. If the sucy wero repeated, de. uncoramy n nok accurately assign a NOAEC. If the study were repeated, the uncertainty in risk Esessmants with irswou be decreased by between &and 10-0. We wil send you a assessments with birds would be decreased by between 5 and I 0-fold. We will send you a Hors detaded analyse 5 hat ou Can cela reposting hs lucy Wowk be user more detailed analysis so that you can determine if repeating this study would be useful. <>] 3.) aQQusueeissntti?oon::seSShhdoouoludn aathccehhriroonnfnoiicrcmffaetoeiadoininnsggvassituuaddbyyibebenecdeoonnoeewrwiaittthuraaenn, taahdddedtiithtioornenasalhlosslppdeeccfoiireeass,fssuuccchhsaaessettmhhese tkc1Cfo0aaeacrsmtbbntiooerirveoorlss?reimemsuisB,is,alaaersrdbbeuunidnntt oaeaeanaaktnntthuuSasemmesebebisenedoedfrsossr.,rsoommffvvaaeesnstgigppsoeeee.ntctcaaiaiteetIiivssooa.d.nnialataHaHbanonwloedwdeweirenvvinvooetvehrrerae,t,rvetlessbaitiibrelnnraracacatteotteeuessttrfh,eh,oe,eaothqaqnneuunaaaatimiihmloroeaaonsnnnnghddgao-smslmldppaaeefllsocclapariieerreedcssiffeaeauusrrc,nenotscucennscooroetthrateiaotmno2typpsy UX, faiT3uannocc0tcotisoepprrrttaiipapsnrinrneeuttoddyysbaeatffdtoacaorccuri,no,tmoro,rraani.snntkTTaasahrrshguigssuueemmwwseseoanmcnutodtlendncccetoorrsneuue.tlssldrduuIaltfttbbdiieieanonntammsasbabwaiooddeuueertbteitt8aodaoev22arr-ef.fielodada0lubduncclegeeninofcooobrrrrrseaaaaesnswsiliaemmaidtiiinnnhdnaaeittthtiheooTeenRttahTTYhleeRRsYaVpaa,ne,mmdcwowioehnrhnsigeig,ccs-shhstspupiewwcnecohogciuuieeall1dsdss wTiVrhcaian~h,zeze'ea.ai'thrhLreiddervirnieqqtuuhhh,ooe,etticvveeucananroltlurtsneientootwwfaf octolfeiuestsulsdsossusebbttehaehtacaousnun~fup,if11~fca0i.ec0i.nni,e~edrnnatcTTttohiht1noousdnsou,os,cfffitsSseneuuutctcbcihhItrhhhdeea~accss,ooetakusks,altdtu.idynyg.SSwwubuooeIcucunlhhlloddCawaohhnsltaakthuvvneudeecylvvocacalanaluunnewe..bbieedTTcChhhooeesennssufistsrr.stuuic.ucuieget.eeddiifsi.s W wwWoeoeuuclhldoauvbbdeee tdqqheuueriiitcsevoessnii8tmamppcpltelseecttitooosscc-eoostnnadudnupucscatitni6ed9gyc9godcniindijiebucucottlionosnun,csshttuuwaddhiiieescstsuhwdwicyi.tohhuId5n conjunction with this study, it boe 6usbedd tspoacveaslsrotmheWnheiecdh or 6 bird species from which w2oforersaacmymoouonldnpgged-GaseppsroievecceiiJoeoasts mssspeeaencKsniientdisov-iwystyeanffnaasdccitttiowvorrietssycaadalllinstotorgdigboeetuvththieoeelnrr,offop8worrhbcbiiocirdshdsts.fc.oouIflCdyyooonbuudeuwwcutiissihehndgttoothoppeorroobtcceveseiaetetddaenwwtdhiitehhwrnsSeuuieccthdh pepo a study please up the report. let me know and we can develop a cost for conducting the test and writing J x DV Question: Shou a toxisty tes be conducted wih Ghicromus fetard? ENTRIX fess Question: Should a toxicity test be conducted with Chironomus tentans? ENTRIX feels at isshouks be done, soener han ate. Theanestuy ats publshed in th erature that this should be done, sooner than later. The one study that is published in the literature reports averylow hrshold value, hl dives the vals calcuatd fo water qual ria reports a very low threshold value, that drives the values calculated for water quality criteria. Becineavaluue1ss muech overthan tht observedfor other space. is ely thal ho ttBeeesscttaiissusrreeeppteheaaetteevddaluuuennddieesrrmGGuLLcPPh,, thal th values lower than that that the values il bo geste. Thi wil haavreoat observed for other species, it is likely will be greater. This will have a great bene 1 that if the benefit in Teducing certainly in ecoiogiel ok assessments for Squalc vertabratos I such a fost reducing uncertainty in ecological dsk assessments for aquatic invertebrates. If such a test 26055..000001 Exhibit 2605 MAS13749 3MA02513749 is conducts, must clude tn same exons measures nh revue sy and aso is conducted, it must include the same endpoints measured in the previous study and also esate Sandars ecdogealy evan endzan, sich sa Sma Gow 3d measure standard ecologically-relevant endpoints, such as survival, growth and Tetatusion aly ard Heung) 30a. oud be Use 1s esas PEOS reproduction (fertility and fecundity). In addition, it would be useful to measure PFOS anon ba he ora oe a5 wel 3 n Dh Seament The Ane concentration in both the overlying water as well as in the sediment. The Aquatic ona Labia 3 onan Ste Uris has Grporens naming So oss Toxicology Laboratory at Michigan State University has experience in running such tests a Govan rochcal est on wich he. care EPA and GED methods and in fact developed the prototypical test on which the current EPA and OFCD methods So asad. ENTRI can aang avs he Ses corded snr a averosr8 are based. ENTRIX can arrange to have these studies conducted either at a university or a oma Aon: ar ie th Sion a7 ADL hs foots ard prepare poe: contract laboratory and oversee the studies and interpret the results and prepare a peerened espaon n heraeas ease mi 308 rowyouwant reviewed literature publication based on the results. Please inform us if and how you want procs to proceed. 5, Questom_ Can ENTRIX praare whe paper on ecologel k assesaments cf PFCs Question: Can ENTRIX prepare a white paper on ecological risk assessments of PFCs, iving PEGS and PEGA The arower & yes. he ov asad coveted 3 of including PFOS and PFOA? The answer is yes- We have already collected all of the on nr rar, rt ct ofr 541 sy on, ich i che res pertinent literature, so that part of the task is already ongoing, which will facilitate preparing ei pop wi reper a is and oes SAAS for HEPA Sch 8 YE the white paper. We will prepare an outline and cost estimate for preparing such a white ep an end 110001 yo ok ncn paper and send it to you for you to make a decision. Ye. ueston: Con ENTRIX wt a saper on ne impact of the 2000 phcautsween Question: Can ENTRIX wdte a paper on the impact of the 2000 phase out with ionsto othr chamicas sue of DO tak had pscon sopper Th vers comparisons to other chemicals such as DDT that had production stopped? The answer is Oe aes au yo wks 8 pa on olin acot ss 1 Sh yes. Please inform us if you would iike us to prepare an outline and cost estimate for such paper a paper. 7. Question, Gan ENTRIX moni R&D and envionment! sve and nate voviog 7. Question: Can ENTRlY, monitor R&D and environmental issues and initiative involving YUbFroEpose ntoeveinorPalarceepeosoa nsu1e0s. a6ia3or3fo1rmdatwiohnBbaegcoimesaakvamleaantd yprepTahree t~~k~1prPoFpCossien tthoegAivseiao-rPaal criefipcorretsgiaosn?issYueess, awrerivceanorainndfowrmeawtioillnbbeegcinomtheisstaavsakilaimbmleeadniadteplyre. pWaree at win 1050 we 55 aking 1 aren documents alan fo 3. Th quarterly written reports as well as making all pertinent documents available to 3M. This Te tora ns ante a unobpaie mat Towad hs a,we wil ani 10 will be done in a discrete and unobtrusive manner. Toward this end, we will continue to lia wring sso inn Koy anor andagence nA. In i wa establish working relationships with the key laboratories and agencies in Asia. In this way, a ast kh enc ht3 l6 3sEE QU we can assure that the science that is done will be of the highest quality. Questor. Should 150 Gevlop siancarized methods for te stunts asses of 8. Qtestion: Should 1SO develop standardized methods for the instrumental analyses of Eh Se hse rd. 1 aria .,,PFCs? The answer is yes and such an initiative is already underway. Dr. N. Yamashita of AST 1 ap a a bo i ot. av vane provoe oman ~ AIST in Japan has taken the lead on this initiative. ~ have already provided information on hate si5 hnon frocees. HW Goss. | a sre toy wh oe hed 3 the first meeting to begin this process. If 3M desires, I can assure that they will be invited to panne ns mae participate in this initiative. =X Wo il contintuo yack ras on pafucenated compeurds. We ilprovide amon ,~9'~. We will continue to track literature on perfluorinated compounds. We will provide a monthly Ie Topo fat Inches he satu and rons of lesion rags. Wo wh ori 1 letter report that indicates the status and trends of publication rates. We will continue to ~, aia oe Reorene Manager Hasire Go 59. maintain the Reference Manager literature data base. 10. yr havs complet h data baseon conceniaoif PaEnCs itehnvionment. Weil 10. V~e-have completed the data base on concentrations of PFCs in lhe environment. We will Rn dora th kaa eo ao 1 rs er 0 Sache ,~ot continue to develop the referential retrieval data base. If in the future there is a specific Teed i Go Ho cam pts at are need ,or thi~ dam &e, vie can update it at that t' e. rors isd ty plans and buorttosps ars ake. Tho st skis to !~l.,~.~will prepare revised study plans and budgets for two separate tasks. The first task is to Five on th NCHA msl wa, programa ana rem fo 3 args of ,~_=~llect mussels from the NOAA mussel watch program and analyze them for a range of PFE and aan a on Geng dy of te Sis nd vend of ese compoince 1 te ~,./z PFCs and maintain an on-going study of the status and trends of these compounds in the ON rte ti: Th aon lok po near-shore marine environment of North Amedca. The second task is to look at methods to eee are snd crates of he ta PE fas I ronan. Tha vale assess the nature and characteristics of the total PFC load in the environment. This will be Sot roe nt wi I ih Uhr of Sascha an can be 16d 33.3 a joint project that will involve the University of Saskatchewan and can be used as a machete io oh key labore and tutors n Asso man 3 wot mechanism to involve key laboratories and institutions in Asia to maintain a working tarp ot howesnes ston nd 1 Huan 0 Quof cyio 1 a relationship that allows access to information and to influence the quality of studies in Asia. Quesion: Gan C*:C* atsbs us 0 ently SourofcPeFCss i the envionment? is Quest=on: Can C :C rabos be used to identify sources of PFCs in the environment. It is hbo deimin the Sts of amropogs eric nh aman an he i~ossible to determine the source of anthropogenio chemicals in the environment using the EE 20s hen manors ov ahem eu alr Hom arent ob ~',?~12:C13 ratios when the manufacturers obtain carbon source materials from different global cations ENTRX can aad shove 8 a condocied a asain hs wo be 2 locations. ENTRIX can arrange to have a study conducted to determine if this would be a TA abun Como ou ECL aia Psi om3 viable method for determining sources of PFCs in the environment. Please inform us if and IV roviasani mosses how you want to proceed. 2605.0002 2605.0002 awsozsta730 3MA02513750