fire is $) up to u4n0c,o0n0w0olglead,lmolafoysgnreeasqutifroer a a substantial large frame quantity of ircraf fire aolorne)etarnodectlhseeaenif-nfuflpuaeeunrctaetiwsisodnairsectheaoxrpegoeisdeetdohatnh2de7t,aht2em0os0si1pthemeierseete.iffnegEc.vt)eedn faofrtedretchaedefsi.re(iNsotoeu:t, Trheiscsuei.s If the exposure issue is not of tbe this specific medical responaibiliy of your maocntiitvoir;in1gwooufldfirgerefaitglhytearpsprfeocriaotcecuypoautsiodinraelcthieoanlth tne appropriate activity. 1 will follow-up onany lead you provide.

The study also has reported an association between benzene exposure and AML, but interpreted the results to indicate that average benzene exposures of around 5 ppm could lead to AML.

Introduction The University of Michigan Dioxin Exposure Study (UMDES) was undertaken in response to concerns among the population of Midland and Saginaw Counties (Michigan, USA) that the discharge of dioxin-like compounds from the Dow Chemical Company facilities in Midland, Michigan (USA) has resulted in contamination of soils in the Tittabawassee River flood plain and areas of the City of Midland, leading to an increase in residents' body burdens of PCDDs, PCDFs and PCBs1.

qrr Charles Auer 05/16/2000 11:11 AM RECEIVED O P P T HC1C 2000S E P -6 PH 12: 57 e2G 0 6 2 - 3 To: cc: Subject: Barbara Leczynski/DC/USEPA/US@EPA, Mary Dominiak/DC/USEPA/US@EPA, Frank Kover/DC/USEPA/US@EPA, Ward Penberthy/DC/USEPA/US@EPA, Karen Lannon/DC/USEPA/US@EPA Phaseout of PFOS fyi Forwarded by Charles Auer/DC/USEPA/US on 05/16/2000 11:17 AM Charles Auer 05/16/2000 11:06 AM To: Charles Auer/DC/USEPA/US@EPA, blnetti@iss.it, John.Bucdnl@ec.gc.ca, "IMCEAFAX-3001+5ECHADJICHRISTIDI+2C+20Konstantina-fax+5E3A23+5E3018662968+5E"@oecd.or g, shchung@me.go.kr, theresa.gilgallon@cec.eu.int, addeke@lss.it, karen_florlnl@edf.org, amst@baua.do.shuttle.de, bjorn.hansen@jrc.it, hasa@env.cz, mark.hyman@ea.gov.au, "IMCEAFAX-3001+5EICONOMOU+2C+20Maria+5E3A23+5E3016465123+5E"@oecd.org, geir.jorgensen@sft.telemax.no, Rainer-Kurt.Koch.RK@bayer-ag.de, Thaly.Lakhanisky@iph.fgov.be, ivarl@kemi.se, majka@bware.imp.lodz.pl, matejova.jana@flora.lifeenv.gov.sk, TM-TNG@mhw.go.jp, laurence.musset@environnement.gouv.fr, jrn@mst.dk, esa.nikunen@vyh.fi, caria.piccinni-leopardi@cec.eu.int, raimund.quint@bmu.gv.at, rosenbaum@biac.org, esilber@epi.umaryland.edu, urs.staempfli@buwal.admin.ch, nagata-reiko@miti.go.jp, roger_tregunno@detr.gsi.gov.uk, Hty@mst.dk, ungvary@elender.hu, kees.van.Leeuwen@rivm.nl, vickersc@worksafe.gov.au, jwillis@unep.ch, younesm@who.ch, Dian.TURNHEIM@oecd.org, Naoyuki.YASUDA@oecd.org, Lesley.ONYON@oecd.org, Oscar Hernandez/DC/USEPA/US@EPA cc: robert.visser@oecd.org, robert.donkers@cec.eu.int, Susan Wayland/DC/USEPA/US@EPA, William Sanders/DC/USEPA/US@EPA, Pep Fuller/DC/USEPA/US@EPA, milroy.breck@epamail.epa.gov, ig232001@wp-gate.bmu.de, Priscilla Flattery/DC/USEPA/US@EPA Subject: Phaseout of PFOS I would like to draw your attention to an important development in the US which concerns a persistent, bioaccumulative, and toxic chemical.

As issues are put on the Chemicals Global Issues List, the affected country external affairs representative and the lead Chemical person in that country should be notified promptly by a Chemicals external affairs representative.

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Polyurethane insulation Ceramic fibers "Sick building" conditions Potential for mine subsidence Lead paint exposure Ventilation/heating/cooling systems Sanitary systems (discharge and ventilation) Fire protection systems Drinking water system Cooling tower systems Present and past chemical use Waste disposal practices both past and current Cleaning materials use and disposal Designate Smoking area ventilation systems Medical Department waste handling practices and X-ray exposure Impact of operation of past and current tenants 5.

Any increment of conversion above this value leads to unstable products.

Because of the cytotoxic effect of hydrocarbons, they can cause injury to the soft tissues, fat and nervous system and may lead to systemic intoxication.

The condition leads to abnormally large amounts of glycogen in the liver, hypoglycemia, increased dependence on fat metabolism, and increased levels of lactate and pyruvate in the blood.

The ultraviolet light end lead to the forma or sampling and analysis.

It was discovered that 50% of miners who developed radiological silicosis did so after exposure to dust had ceased - a finding which should lead to renewed efforts to reduce silica exposure and a review of medical surveillance in ex miners.

As specified in the Haskell Laboratory animal health and environmental monitoring program, the following procedures are performed periodically to ensure that contaminant levels are below those that would be expected to impact the scientific integrity o f the study: Water samples are analyzed for total bacterial counts, and the presence of coliforms, lead, and other contaminants.

PtfLSL&6 - ///3 15 July 2002 CCUWhhSaaesErmhlPeiinscAgaMlt-oC.OnAo,PnDuPterCTroS,l2DD0i4irv6ei0cstioorn Ref.

.; Mike Johnston to work with John on issue (J) I m r r sI : () () r C ;a G) oI c..n -.....J AUTOPATH o o (J) Page 3 of 12 BHRC OVERSIGHT COMMITTEE & COMMITTEE CHAIR CALL ACTION ITEM TABLE Last updated 1115/04 OC lead on lab transition/turnover plan development; work with I M.