Purpose: AR226-2366 DRAFT *' J-- t> I--V^.

AR226-2503 George Woytowich 0 8 /0 6 /2 0 0 1 0 9 :1 6 AM To: H David Ramsey/SE/DuPont@DuPont cc: Dawn D Jackson/CL/DuPont@DuPont Subject: Re: Lubeck Testing B l (1 ) Yes, 1992 data is. from the New Lubeck location

FOR DU PONT USE ONLY AR226-2962 Du Pont HLO 432-91 Study Title Skin Sensitisation Test with A n p f l H H n i n Guinea Pigs Study Completed On July 31, 1991 Contracting Laboratory Pharmakon Research International, Inc.

AR226-3043 Study Title Eye Irritation Test with H-2I987 in Rabbits Laboratory Project ID Haskel!

tFM recherche $. v i MJ C-W'At OS 5 5>0 000 c A R226-3134 CONFIDENTIAL SPONSOR Elf Atochem S.A.

CORNING Hazleton MUTAGENICITY TEST ON T- 6294 EER IN AN IN VIVO MOUSE MICRONUCLEUS ASSAY. 225500 | May14 1995 FINALREPORT A aM a Qtrc010> AUTHOR Hemalatha Murli, Ph.D.

Study Tite #R226_ 1092 ORAL (GAVAGE) TWO-GENERATION (ONE LITTER PER `GENERATION) REPRODUCTION STUDY OF AMMONIUM PERFLUOROOCTANOATE (APFO) IN RATS SPONSOR'S STUDY NUMBER: T-6889.6 Data Requirement U.S.

ACUTE TOXICITY TO AQUATIC INVERTEBRATES (E.G.

: AR 226 _ 08ST TOXICITY TO AQUATIC PLANTS IESTSUBS ~~ T0 A0 N0C 0E 0 Identity: A mixture containing perfluorooctanesulfonate, which may also be referred to as PFOS, FC-95, or as a component of FC-603EF.

Test Substance: Toxicological Summary Pros Dietary Acute Northern Bobwhite Study Perfluorooctanesulfonate (PFOS) Structure: Remarks: p1o-tOacstsaineusmuslaflot,niCcASa#cid2,7951,.13,92..32.3,3,4,4,5,5,6,6,7,7.8,8,8-heptadecafluoro-, The test substance is stored under ambient caonwdhiittieonpsoawndderpuGriMty wloats#o21r7g)i.nallTyhedestaemrpmlienewdatso bteechn9i0q.ue4s9.% determined Ibny 10 a LsCu/bMsSeq,uen'tH-aHnaMlRy,sis "oFf-tNhMeRestandsubcslteamnecnet,alpuraintaylwysaess be 86.9%.

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AR226-3003 '-- ' ;a -'.?""

AR226-3094 TRADE SECRET FINAL REPORT Study Title H-23005: IN VITRO MAMMALIAN CELL GENE MUTATION TEST WITH AN INDEPENDENT REPEAT ASSAY LABORATORY PROJECT ID: HLO-1998-01211 AUTHORS: Richard H.C.

Corporate Health-Physics CorporateOccupationalMedicine CorporateProduct Responsibility Corporate Toxicology 3M Medical Department 3M Center,220-2E-02 PO Box 33220 St.Paul,MN 55133-3220 651733 1110 Working Memorandum on Data QualityAssessment(oftheMean and Range of PFOS (ppb)LevelsinCurrent and HistoricaHluman Populations) ThisreportdocumentsBattellee'vsaluatioonfthestatistiqcuaallitaynd defensibiliotfy 12 datasourcesof serum perfluomoctanesulfona(tPeFOS) levelsfound innonoccupationahluman populations.These datawere summarized inthe3M whitepaper, "PerfluorooctanSeulfonate:CurrentSummary ofHuman Sera,Healthand Toxicology Data" providedtotheEPA inJanuary,1999.The purposeof thisinitiaclollectioonf human non-occupationaslerum samplesby the3M Medical Department was to determinethepresenceor absenceofPFOS inhuman blood from currentand historical samples. 3M requesteda reviewofthesedata by Battellteo determinewhat additional inferencescouldbe obtainedby analysesofthesedata.Battellsetatisticiafneslthatonly thepooled serum from the 18 U.S.blood banks was judged defensiblefora statistical analysis.Of thesedata,thegeometricmean PFOS blood levelwas 28.2ppb (95% confidenceinterva2l3.9-33.3).Regionaldifferencecsouldnotbe explainedwithout additionadlata and analyses.

ACUTE TOXICITY TO FISH (FATHEAD MINNOW) TEST SUBSTANCE Identity:Perfluorooctanesulfonylamido(ethyl)acemtaaytea;lso be referredto as PFOSAA, FC-128 or as the major component of FC-1 27, FC-1 29, FC-1 09, FC-1 09-X or Rl 904.