SL 110707 -1- THE MUTAGENICITY AND CARCINOGENICITY VINYL CHLORIDE :A HISTORICAL REVIEW AND AS S ESS M ENT OF SUMMARY In 1974 the first evidence that occupational exposure to vinyl chloride (VC) could lead to a rare type of liver cancer in man, angiosarcoma, was published.

t NCI/ICRDB/OK-80/04 PB80-922904 ONCOLOGY OVERVIEW SELECTED ABSTRACTS ON i i THE CARCINOGENICITY OF VINYL CHLORIDE AND RELATED COMPOUNDS March 4, 1980 U.S.

Asbestiform Fibers Nonoccupational Health Risks Committee on Nonoccupational Health Risks of Asbestiform Fibers Board on Toxicology and Environmental Health Hazards Commission on Life Sciences National Research Council NATIONAL ACADEMY PRESS Washington D C. 1984 i National Academy Press 2101 Constitution Avenue, NV Washington, DC 20418 NOTICE: The project that Is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

Members of the ECETOC Scientific Committee 141 142 144 146 147 SPI-00682 T -1- THE MUTAGEN ICI Y AND CARCINOGE N I C I T Y VINYL C H L OR I D E : A HIST 0 R I C A L REVIEW AND ASSESSMENT OF SUMMARY In 1974 the first evidence that occupational exposure to vinyl chloride (VC) could lead to a rare type of liver caicer in man, angiosarcoma, was published.

1 IN THE UNITED STATES DISTRICT COURT 2 FOR THE WESTERN DISTRICT OF TE, NESSEZ 3 EASTERN DIVISION 4 5 6 WOODROW STERLINGp at alp 7 Plaintiffs, 8 Vs . 9 VELSICOL CHEMICAL CORPORATION* 10 Defendant . 11 ) . 78-1100 12 13 14 15 TRANSCRIPT OF THE EVIDE 16 VOLUME LVIII 17 SEPTEMBER 20, 1983 18 19 20 21 22 23 24 25 )7 8690 1 IN0EX 2 DIRECT 3 Raymond D .

REGULATORY TOXICOLOGY AND PHARMACOLOGY 7, l --20 { \ 987> Criteria for Identifying and Classifying Carcinogens, Mutagens, and Teratogens Developed Jointly by an International Working Party of Experts, Organized under the Auspices of the Safely ofChemicals Committee ofCEFIC InternationalAffairs Group ofCMA/SOCMA and Canadian Chemical Producers Association' Received May 29, 1986 AUTHORS Cochairmen B.

39615-621 missing 8:30-8:35 a.m. 8:35-8:40 8:40-8:45 8:45-9:30 9:30-9:45 9:45-10:25 10:25-10:50 10:50-11:05 11:05-11:20 11:20-11:40 11:40-11:45 11:45 AGENDA CMA EXECUTIVE COMMITTEE MEETING 8:30 a.m., Wednesday, March 5, 1986 Grand Hyatt Hotel Music Box/Morocco Rooms New York City, Nev York __________________ TAB 1.

IN THE CIRCUIT COURT 1 TWENTIETH JUDICIAL CIRCUIT OF ILLINOIS ST.

CHEMICAL MANUFACTURERS ASSOCIATION \ March 13, 1985 'V Dear Vinyl Chloride Panel Member : An article on the "Occupational Hazards of vinyl Chloride and Styrene" was sent to you wit:h every other page inadvertanly missing.

1 HEALTH PAC Health Policy BULLETIN Advisory Center Volume 11, Number 3 January February -, 1980 HPCBAR 1-40 ISSN 0017-9051 1 Bakke - ing Up the Wrong Tree: NEW MYTHS FOR OLD RACISM AND SEXISM: The second in a two part study of medical school admissions in the post Bakke - era. 3 Vital Signs 17 Columns URBAN: Health and Hospitals in Critical Condition WORK ENVIRON / : Merchants of Death and the Global Dumpground WOMEN: Not Teaching Old Dogs New Tricks THE FIFTH COLUMN: Human Rights for FNGs 29 Media Review The Cultural Crisis of Modern Medicine by John Ehrenreich 35 Peer Review Bakke - ing Up the Wrong Tree NEW MYTHS (This is the second article in a series on affirma- RACISM FOR AND OLD tive action in U.S. health professional schools.

In addition I was co-author of a publication of a study of lead solder workers.

. ( * vivif: DIOXIN REPO RT B A C&EN SPECIAL ISSUE G03718 ti In the annals of environmental con widely varying toxicity.

CHEMICAL MANUFACTURERS ASSOCIATION March 13, 1985 Dear Vinyl Chloride Panel Member: An article on the "Occupational Hazards of Vinyl Chloride and Styrene" was sent to you with every other page inadvertanly missing.

REGULATORY TOXICOLOGY AND PHARMACOLOGY 7, l --20 { \ 987> Criteria for Identifying and Classifying Carcinogens, Mutagens, and Teratogens Developed Jointly by an International Working Party of Experts, Organized under the Auspices of the Safely ofChemicals Committee ofCEFIC InternationalAffairs Group ofCMA/SOCMA and Canadian Chemical Producers Association' Received May 29, 1986 AUTHORS Cochairmen B.

And in 1953, Doctors Birmingham and Denton were 16 recommending a basic research that would allow Monsanto or 17 whoever does the research that they say it might well lead to 18 being able to predict whether or not other chlorinated 19 hydrocarbons would be hazardous in future operations, isn't 20 that correct, sir?