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^/ REVIEW OF THE NATIONAL AMBIENT AIR QUALITY STANDARDS FOR LEAD ASSESSMENT OF SCIENTIFIC AND TECHNICAL INFORMATION DRAFT OAQPS STAFF PAPER BRIEFING FOR CASAC MARCH 11, 1986 N 31045 TEH 0413108 PURPOSE 0 Re v ie w r e v is io n s t o f ir s t d r a f t s t a f f p a p e r 0 Re v ie w s t a f f f in d in g s a n d r e c o mme n d a t io n s 0 Dis c u s s imp l ic a t io n s o f r e c e n t a d u l t d a t a o n b l o o d pr essur e 0 Re v ie w e x p o s u r e /r is k a s s e s s me n t me t h o d o l o g y TEH 0413109 DUP050454164 AIR STANDARD MULTI-DIMENSIONAL Co n c e n t r a t io n Le v e l Av e r a g in g Time Fo r m Al l In t e r a c t t o De t e r min e Le v e l o f Pr o t e c t io n Cu r r e n t St a n d a r d Se t in 1978 - Pr ima r y 1.5 u g /m5, q u a r t e r l y me a n - Se c o n d a r y 1*5 u g /m5, q u a r t e r l y me a n TEH 0413110 DUP050454165 MAJOR REVISIONS TO FIRST DRAFT STAFF PAPER New s e c t io n o n e x p o s u r e t o l e a d -b a s e d p a in t - Be t w e e n 6-2 a n d 13-6 mil l io n c h il d r e n u n d e r 7 l iv e d in l e a d -b a s e d p a in t e d h o u s in g in 1980 - 235-842 t h o u s a n d in h o me s w it h d e t e r io r a t in g c o n d it io n s - Emp h a s iz e s t h a t h ig h e x p o s u r e t o l e a d in p a in t w il l n o t BE SIGNIFICANTLY INFLUENCED BY CHANGES IN AIR LEAD EMISSIONS - NO ATTEMPT TO ESTIMATE EXPOSURES OF CHILDREN WITH IDENTIFIED EXPOSURES TO PAINT LEAD Re c e n t l y a v a il a b l e h e a l t h s t u d ie s - Ne u r o l o g ic a l e f f e c t s (e -g -, a l t e r e d a u d it o r y f u n c t io n , SMALL IQ DEFICITS) ASSOCIATED WITH LEAD POSSIBLY BELOW 25-30 u g /d l - Da t a o n c a r d io v a s c u l a r a n d g r o w t h e f f e c t s n o t y e t INCORPORATED AS A KEY CONSIDERATION In c o r p o r a t e d CASAC'S r e c o mme n d e d r a n g e f o r ma x imu m ACCEPTABLE PbB LEVEL FOR INDIVIDUAL CHILD OF 15~20 UG/DL Re s u l t s o f e n c o d in g e x p e r t j u d g me n t o n l e a d -in d u c e d HEMOGLOBIN AND IQ DEFICITS Ex p a n d e d d is c u s s io n a n d r a t io n a l e f o r mo n t h l y a v e r a g e , STATISTICAL FORM, AND SAMPLING FREQUENCY CONSIDERATIONS Qu a n t it a t iv e p r e d ic t io n s o f l o n g -t e r m l e a d d e p o s it io n IN RURAL AREAS TEH 0413111 DUP050454166 STEPS IN ESTABLISHING PRIMARY STANDARD LEVEL 0 Se l e c t "ma x imu m a c c e p t a b l e " Pb B f o r s e n s it iv e p o p u l a t io n 0 Ch o o s e "mo d e l " o r mo d e l s f o r e s t ima t in g p o p u l a t io n me a n BLOOD LEAD UNDER ALTERNATIVE AIR LEAD LEVELS 0 Se l e c t p e r c e n t a g e o f c h il d r e n t o p r o t e c t f r o m e x c e e d in g "ma x imu m a c c e p t a b l e " Pb B 0 Ca l c u l a t e p o p u l a t io n me a n b l o o d l e a d r e q u ir e d t o p r e v e n t A GIVEN PERCENTAGE OF CHILDREN FROM EXCEEDING "MAXIMUM a c c e p t a b l e " Pb B 0 Ev a l u a t e ma r g in o f s a f e t y c o n s id e r a t io n s - RANGE OF BIOLOGICAL SENSITIVITIES (E*G., DEFICIENCIES IN NUTRITION,; CAREGIVING) - WIDE VARIABILITY IN EXPOSURES FROM NON-AIR SOURCES, ESPECIALLY PAINT LEAD TEH 0413112 DUP050454167 RISK ASSESSMENT: EXPERT JUDGMENTS ON IQ AND HEMOGLOBIN DOSE-RESPONSE 0 In g e n e r a l , j u d g me n t s t e n d t o s u p p o r t r a n g e o f 15-20 u g /d l AS APPROPRIATE FOR DECISION ON MAXIMUM ACCEPTABLE PbB 0 Me t h o d o l o g y , p r o t o c o l d e v e l o p me n t s , e x p e r t s c o n s u l t e d , WILL DISCUSS TOMORROW 0 He a l t h e n d p o in t s a s s e s s e d n o t n e c e s s a r il y in d iv id u a l EFFECTS MOST CRUCIAL IN DETERMINING MAXIMUM ACCEPTABLE Pb B 0 Ju d g me n t s o f s o me e x p e r t s s u g g e s t s ma l l p r o b a b il it y OF EFFECTS ON IQ AND HEMOGLOBIN < 15 UG/DL TEH 0413113 DUP050454168 APPROACHES TO ESTIMATE Pb B LEVELS UNDER ALTERNATIVE AIR LEAD LEVELS In t e g r a t e d Le a d Up t a k e /Bio k in e t ic Mo d e l - Es t ima t e s o f d a il y u p t a k e f r o m d if f e r e n t e x p o s u r e me d ia (e .g *, a ir , d u s t , d ie t ) - NYU b io k in e t ic c o mp a r t me n t a l mo d e l Ag g r e g a t e Mo d e l - Re l a t io n s h ip s b e t w e e n b l o o d l e a d a n d "t o t a l a t mo s p h e r ic " l ead - Ad d n o n -a ir "b a c k g r o u n d " Pb B c o n t r ib u t io n CD Dis a g g r e g a t e Mo d e l - Re l a t io n s h ip s b e t w e e n b l o o d l e a d a n d in d iv id u a l e x p o s u r e MEDIA (E.G., INHALATION, DUST, SOIL, FOOD INGESTION) - Co mb in e in p u t s , a d d t o b a c k g r o u n d Pb B TEH 0413114 DUP050454169 SUMMARY OF ESTIMATED BLOOD LEAD LEVELS UNDER DIFFERENT AIR LEAD LEVELS USING THREE MODELLING APPROACHESA TEH 0413115 /-s y**v *=r o LU o* ia CD l h o CO < Lf\rH OTr--1 cc r-- OJw IAw Ui > < >- J oc LU T C 3 a ---1 orv cr * CC o * rH o cnrv r^i-H rHw Ol'--' > -j X H z o z N ia Z V o y--V SI c t o j Ln ooco -1 o=r p a ia o rH'W rH w Ui > Ui ___1 o < UJ * -J V. - UJ Z -J ha 0or < < z a: -* CQ CC 3 =c os 3 o o 0-00 CQ a CJ UJ -4 h- K <^.

S.V. 243 ,/g44~j < AUTOMATED') BATE PRINTED: 6/25ZS2 CG 03 CODE J< Y-7S7-D PKG Jj52 < BATE > _G2Jfi9 3404* < LOT ) // ( EST UGT ) PROCESSES A.PPROV ffeY ~ ( ) KY-7S7-D <T> FUP 06/25/82 COMTYP JOB NAME: 03KY787BMT LOCATN CG CODE PQ LOT DRY WEIGHT jktL DRY NO.