In meeting this obligation, Monsanto took the lead within the Chemical Manufacturers Association to develop EX P-3334 Page 2 of 5 PCB-ARCH-EXT0381701 -3- an industry-wide program for assessing the safety of a widely used family of chemicals, phthalate esters.

It vaa concluded that under the conditions of the present experiments - VCi at a level of 1,3 ng/kg body velght/day Induces neoplastic and oon-neoplaatlc changes in the liver of rats, " VO{ at a level of 0.13 ng/kg body valght/dsy may lead to more female rats bearing foci of cellular alteration in tha liver, - VCM at levels of 0.011 or 0.13 mg/kg body weight/day may result in an increased incidence of basophilic foci of cellular alteration in the liver of female rats, - 0.13 mg VCM/kg body waight/day Is a "no-obssrved"edverse--effectlevel' with raepect to the induction of tumours In rata. 33 99 03 O oro 07 fO ' v d3.285 9- Silk eatlaaclon baaed on chi reiulta of the preient rat scudy and Caking into account tha prudence of the linear model applied and a lener aertiitlvity of huaani to the catcinogenlc action of VCH in compariion with rati, iodieatea that the cancer riilc of a likely maximum oral daily intake of 0.1 fig VCH per penoa per day can be practically neglected. 33 U) O O to O) 03 v--1--i--> Meeting October 5, 1984 Present: C.

This should lead to a reaffirma tion of PVC's suitability for all food contact applica tions and ultimately ATF approval of PVC liquor bottles.

The employer may not use the pre-place ment medical examination data to speculate on the long-term possibility that the conditions will progress or lead to inability to work or to perform a specific task.

The discussions leading up to the settlement agreement, however, focused on the 1 ppm TWA for EDC.

C1006 REQUESTOR NAME: EAR/MTE DEPARTMENT: 0535 PROJECT NO: 9970012600 DATE RECEIVED: 01/03/1985 DESC: ENVIROMENTAL SCREENS ON FX-1001(FC-26) CONTRACT LAS(S): EXP COMP DATE: 02/18/1985 DATE COMPLETED: 02/14/1985 PROJECT LEAD: ST WOLF PHONE NO: 651-778-4048 3M FAX NO: 651-778-6176 NEUTRALIZE PRODUCT WITH NAOH PRIOR TO BOD + FISH TEST.

As we have determined from talking to companies within the chemical industry, and as EPA's economic consultants recognize, the expense involved in the EPA proposals may lead many operators to choose retrofill or removal even if such actions are not mandated, Serious questions for which the record offers no firm answers are raised by these proposals: PCB-ARCH-EXT0371941 TSH21-J - 3 - -- Will fires involving transformers be more, or less, likely should any of these controls be imposed?

Included chest X-rays, pulmonary function te s ts , a re sp lrato ry /neurobehevloral questionnaire and, fo r a ll chealcal products employees, blood samples fo r lead analysis..

Denner, Jr. 450-72-5479 1/25/88-2/1/88 Extravasation of blood from venipuncture done in plant dispensary for blood lead determination (OSHA-required examination).

Work that has been labeled as menial and is poorly paid is unlikely to lead to a satisfied work force.

To the extent that accidents have occurred in food and feed manufacturing plants leading to PCB contamination, this retro-fitting require ment may be justified.

The Thermal Insulation Manufacturers Association, commonly known as TIMA, has taken a proactive approach to ensuring that fiber glass is safe by sponsoring health studies, which are conducted by leading scientists at Independent U.S. national laboratories and universities.

. & Recommend F,lare Pit-Investigate draining standing water on walkway leading to east stair way -into the flare pit.

Clapp asked a number of "leading and provoking" questions about the work practices and exposures at the plant.

Our informal talks with the FDA staff lead us to believe that the potential problems with these issues and those noted in our February 4 letter should not be difficult to resolve and need not occasion any long delay in finalizing the February 3 rulemaking proposal.