This will lead to an increase in the level of reactive metabolites and result in an increased reaction of these metabolites with intra cellular macromolecules.

Use of temperatures above 2GQ"'C to spaed vaporisation into the chromatograph column lead to cracking of ethyl ana dichloride and ethyl chloride with subsequent above theoretical reccvru.7/ of vinyl. chloride*.

This will lead to an increase in the level of reactive metabolites and result in an increased reaction of these metabolites with intra- cellular macromolecules. 0000^ If -2- Chemical carcinogenesis has been attributed to the reaction of electrophiles with intracellular macromolecules (Miller and Miller, 1971).

T (DraTt) / ` A /- AS33ST0S TEXTftLE INSTITUTE Minutes - GENERAL MEETINGV^Beifruary I)., 1971 The RED CARPET INN, Charlotte, N.C.

ft} 1977 ANNUAL REPORT D10004Q4 President Daniel C* Braun, M.D, Director of Office Services Sally Jo Carlysle Director of Engineering Services Michael Brian, M.S.

PC3s do not occur naturally but ore wholly synthetic substances which are generally very stable (stability increasing with degree of chlorination) and which persist in the environment for very long periods* Their high fat-solubility and the fact that some are metabolised and excreted only very slowly leads to their concentration and accumulation in the fatty tissues of living organisms.

o hydrosphere, the transfer processes will lead to a w:_e distribution of these compounds, wnli aerial uatwpur: playing a major part.

One suggested that it was for hazardous substances control and perhaps the Committee should he called ~ the Hazardous Substances Committee.2 A Committee member pointed out _ , D that "lead and silica have problems, perhaps not on the sane scale with ^ asbestos, but they are of concern in the work placed.

General conditions, (a) That all dis charges or deposits shall be consistent with the terms and conditions of this permit; the discharge or deposit or any material or sub stance not specifically identified and author ized herein or the discharge or deposit of any material or substance more frequently than or at a level in excess of that identified and authorized herein shall constitute a violation of the terms and conditions of this permit; any violation of the terms and con ditions of this permit shall be unlawful and may result in the institution of such legal proceedings as the Government may consider appropriate, whether or not this permit has been previously modified, suspended or re voked; a violation of any of the terms and conditions of this permit may also lead to the modification, suspension or revocation of this permit.

J " W I I H .J H .................................V9JM.

Although the mechanism of formation was not investigated, we felt that acetaldehyde, a known dissociation product of Sj-vinylcysteinederived S^vinylcysteine-S-oxide (4) might undergo concerted condensation with N-acetyl-S-(2-methoxyethyl)cysteine leading to elimination of thermodynamically stable glyoxylate.

Gehring* The metabolism of inhaled vinylidene chloride in rati represents a balance of biotransformation path ways leading to the formation of a reactive alkylating species which is normally detoxified by conjugation with glutathione.

UNIVERSITY <).!'

BENZENE AND HEALTH VJOEKBOOK 1973- Howell Corporation, Training Division CONTENTS Page Number Introduction ....................................................................................................................................

Environmental Health Perspectives Vol. 17, pp. 11,5-152,1976 Dose-Dependent Fate of Vinyl Chloride and Its Possible Relationship to Oncogenicity in Rats by P.