UNITED SIERRN B O X 1201 T R E N T O N , NEW J E R S E Y 08606 DIVISION CYPRUS MINES CORPORATION T E L E P H O N E 609*883-5111 TWX 510*685-9585 December 21, 1973 Hearing Clerk Food & Drug Administration Room 6-86 5600 Fishers Lane Rockville, Md. 20852 Subject: Asbestos particles in Food and Drugs, the subject of proposed rulemaking of the Food and Drug Administration, Federal Register, Vol. 38, No. 168, 9/28/73, (21 CFR P arts 121, 128 and 133) Dear Sir: As a. major talc producer, this division is vitally concerned with this subject.

THE UPJOHN KALAMAZOO, MICHIGAN 49001 TELEPHONE (616) 382-4000 COMPANY May 20, I976 OHfAfiRcReYofR ALLEN, M D Manager, FDA Liaison Domestic Pharmaceutical Medical Affairs Hearing Clerk Food and Drug Administration Room L-65 5600 Fishers Lane Rockville, Maryland 20852 Dear Sir: In compliance with the Federal Register Notice, Volume Lo, Number 51, March lL, 1975, page 11865, titled "Asbestos-form Particles in Drugs for Parenteral Injection", we are supplying the attached memo as an updated report for replacement of asbestos filters.

COLGATE-PALMOLIVE COMPANY 909 River Road Piscataway, N.J. 08854 Norman F.

MEMORANDUM oe . _^<- DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE PUBLIC HEALTH SERVICE FOOD AND DRUG ADMINISTRATION T O George H.

ifetrch 5, 1973 M$* liarjorie &*K* Inservice Education Coordinator Edgamoor Geriatric hospital Horth Mgemoor Drive Santee, California 92071 Dear He* Briggsi Vour letter o February 6, 1973 to the attention of the Food and Drug Administration hm been referred Iso me for reply* We are at present cxapilta$ information on various talc products, but this is not yet ready for release* Inhalation of large rraomat of eshastee, a# in occupational exposure, is kno&tt to increase the incidence of lung cancer and pwseothelfossa, e&peeially in heavy sobers of cigarettes* Aabeafcos is often found- as a. natural contaminont of talc; both are magnesium silicates, end aro geochemicalXy Infcercoarvcriifele* Taleoei* if seaa only tmder conditions of heavy exposure and talc has not been demonstrated of itself to bo careino^onic* the levels of the various types of asbestos found in talc vary depending upon the source frm. which the talc comas, and: the use for Which it is intended, i.s* ties in heavy Industry, food UqpmUmdt, cosmetic* Generally* the bat-tar grades of commtc and food talcs are reportedly free of ae~ bastes* Iveadlcss to- ay, the suppliers and cotaaercial users of talc are aware of the potential problems presented cad in the last year or so the industry lias made an effort to reduce or eliminate asbestos in talc as required* Two statements from 1971 report on Asbestos by the national Acatoay of Sciences are of interest there are levels of asbestos exposure that will not he associated vlth any detectable risk.

'ooocoouooe TRcrr M r.

October l i , 1973 Ernest F , Fullam Associates P.

The Cosmetic, Toiletry and Fragrance Association, Inc. 1133 15th STREET, N.W..

h' April 26, 1976 T0: R.

FILE NAME: Kentile (KEN) DATE: 1978 Apr 7 DOC#: KEN032 DOCUMENT DESCRIPTION: Confidential Memo to Distribution RE Chicago Trip for Air Sampling and Inspection of In-Plant Environment STRICTLf COfiflbENTIAL I cj listributicn April 7, 1978 Fresa : J- Sorgi Sui-3 Trip to Chicago for CSFv Sampling 2n d Inspection of In-Plant Environment The purpose of this trip was two-fold.!

FILE NAME: Riverside Cement (RVC) DATE: 1974 Aug 5 DOC#: RVC007 DOCUMENT DESCRIPTION: Memo m Johns-Manvle Internal Correspondence To: J.

FILENAME: Flintkote (FLK) DATE: 1976 Oct 8 DOC#: FLK022 DOCUMENT DESCRIPTION: Memo RE Product Liability Private Labels } Mr.

FILENAME: Flintkote (FLK) DATE: 1977 Mar 21 DOC#: FLK113 DOCUMENT DESCRIPTION: Memo RE Compensation Claims Involving Asbestos THE FLINTKOTE COM PANY INTEROFFICE CORRESPONDENCE Mr.

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1973 Jan 22 DOC#: API192 DOCUMENT DESCRIPTION: Memo from Division Headquarters RE OSHA Compliance with Discussion of Timelines of Various Companies for Transferring to Asbestos-Free Products Q ftLIC/AltJ/Wo Mwlalon Headquarcara January 22, 1973 f . 3, SOLON - 1 Woat ac: R.

FILE NAME: Philip Carey (PC) DATE: 1977 July 8 DOC#: PC045 DOCUMENT DESCRIPTION: Memo-Asbestos Warning Labels v /> , 3 ' * - <f to: Peter Reiser from: AB Bagenstose SUBJECT: INTERNAL CORRESPONDENCE DATE: July 8th, 1977 CC: Peter, Charles Wilson, V.