You are quite right in assuming that both experimentation and experience have shown that the absorption of lead from petrol containing the commer cial quantities of tetraethyl lead, is negligible.

I have occastion to fly airplanes powered with Hornet motors, which are fuled with tetraethyl lead gasoline and this has aroused my curiosity, I shall be greatly obliged if you can furnish me with any information regarding the inhalation of exhaust gas of this type.

June 10, 1935 Dr* Graham Edgar Ethyl Gasoline Corporation Chrysler Building Hew York City New York Dear Edgars Within the next ten days I hope to have completed the studies which we have been making on the absorption of tetraethyl lead out of lubricating oil W studied this question, making use of experimental animals frequently exposed to various concentrations of lead In oil# Some of the work is already finished but I am waiting for the analytical data on the lower con centrations# 411 the indications are that the rate of absorption out of oil is somewhat lass than out of gasoline I am expecting to leave Cincinnati the last week in June or the first week in July to be gone on a, vacation for some weeks# However, I shall make it a point to got the report on these studies Into your hands before I go away# If there are any other matters pending which may" require my attention before I go away, I would be glad if you would bring them to ray attention at once# With kindest personal regards, Cordially yours, RAKsTS HE 0015537

June 29, 1933 University of Cincinnati, College of Medicine, General Hospital, Cincinnati, Ohio Gentlemens In reply to your letter of June 27th, we do not have any chemical cartridge respirator that we would recommend for use in a lead tetraethyl atmosphere.

June 10, 1935 Dr, Graham Edgar Ethyl Gasoline Corporation Chrysler Building Hew York City New York Dear Edgars Within the next ten days I hope to have completed the studies which we have been making on the absorption of tetraethyl lead out of lubricating oil We studied this question, making use of experimental animals frequently exposed to various concentrations of lead in oil# Some of the work is already finished but I am waiting for the analytical data on the lower con centrations e All the indications are that the rate of absorption out of oil is somewhat less than out of gasoline I am expecting to leave Cincinnati the last week in June or the first week in July to be gone on a vacation for same weeks * However, X shall make it a point to get the report on these studies into your hands before I go away# If there are any other matters pending which may require my attention before I go away, I would be glad if you would bring them to my attention at once# With kindest personal regards, Cordially youra, RAKsIS XE 0015537

In the course of the past several years I have seen several fatal oases of lead poisoning in children *3 the result of Ingesting lead from toys, play pens, and in one instance contaminated food, I have also seen several cases of fatal encephalopathy in eonneotlon with the manufacture of white lead, I have also had direot knowledge of ala or seven deaths from acute organic lead poisoning in connection with the cleaning of storage tanks heavily contaminated with tetraethyl lead or its decomposition products, I can not con ceive of these as having muoh significance in relation to the general question of mortality.

In the course of the past several years I have seen several fatal oases of lead poisoning in children *3 the result of Ingesting lead from toys, play pens, and in one instance contaminated food, I have also seen several cases of fatal encephalopathy in eonneotlon with the manufacture of white lead, I have also had direot knowledge of ala or seven deaths from acute organic lead poisoning in connection with the cleaning of storage tanks heavily contaminated with tetraethyl lead or its decomposition products, I can not con ceive of these as having muoh significance in relation to the general question of mortality.

This, I am sure, is because actual lead absorption has been reduced practically to the vanishing point in men engaged In this work, I am sure that this will be the case everywhere if the work is don properly* You will note that the initial symptoms of significant exposure to tetraethyl lead differ quite appreciably from the customary clinical picture of lead absorption.

We have had several thousand men under our care in this country for years without having had a single case of lead poisoning* This, I am sure, is because actual lead absorption has been reduced practically to the vanishing point in men engaged In this xtork, I am sure that this will be the case everywhere if tho work la done properly* Tou will note that the Initial symptoms of significant exposure to tetraethyl lead differ quite appreciably from the customary clinical picture of lead absorption* On the other hand, there is every reason to believe that prolonged slight exposure would result in the usual clinical manifestations of chronic lead poisoning* Accordingly wo make It a practice to examine every man carefully with reference to suggestive acute symptoms, as well as the blood and other clinical evidences of chronic lead absorption* Our studies on the lead excretion of men In this work have demonstrated that there occupational load absorption is insignificant if the conditions of their work are as they should be.

We have had several thousand men under our care in this country for years without having had a single case of lead poisoning* This, I am sure, is because actual lead absorption has been reduced practically to the vanishing point in men engaged In this xtork, I am sure that this will be the case everywhere if tho work la done properly* Tou will note that the Initial symptoms of significant exposure to tetraethyl lead differ quite appreciably from the customary clinical picture of lead absorption* On the other hand, there is every reason to believe that prolonged slight exposure would result in the usual clinical manifestations of chronic lead poisoning* Accordingly wo make It a practice to examine every man carefully with reference to suggestive acute symptoms, as well as the blood and other clinical evidences of chronic lead absorption* Our studies on the lead excretion of men In this work have demonstrated that there occupational load absorption is insignificant if the conditions of their work are as they should be.

Fishbeln: I am sending you herewith an article v/hich contains the results of several years experi mentation with tetraethyl lead.

Kehoe University of Cincinnati College of Medicine Cincinnati,Ohio Dear Dr, Kehoe Thank you for your instructive letter on tetraethyl lead.

Fishbeln: I am sending you herewith an article v/hich contains the results of several years experi mentation with tetraethyl lead* I am sending It to the American Medical Association because 1 think there are some matters In it that are of interest and importance to the medical profession at large.

The tests in question were repeated using gasoline colored red but containing no tetraethyl lead.

The tests in question were repeated using gasoline colored red but containing no tetraethyl lead.