Housekeeping in this area is poor, however, aid sloppiness In this respect may eventually lead to serious industrial hygiene problems where any of the dlIsocy anates are handled.

Willtarns and Hugh-Tones**0 showed wide disparity in the opinions registered by 11 experienced observers in assessing the roentgenograms ot patients with established asbestosis The roentgenographic changes in the lungs may be divided into three stages:** (1) a fine reticulation occupying pre dominantly the lower lung zones, asso ciated with a "ground-glass" appearance which has been attributed to pleural thickening although without absolute justi fication;**0 (2) a stage in which interstitial reticulation becomes more marked; a com bination of parenchymal and pleural changes leads to partial obscuration of the heart border--the so-called "shaggy-heart" sign--and of the diaphragm (Figure iz-idj; and (3) a late stage in which reticu lation becomes visible in the mid and upper lung zones and the cardiac and diaphragmatic contours become more ob scured.***' ** Hilar lymph-node enlarge ment is seldom if ever notable.*31 r The vlettral manifestations dominate the pjrhirp rrtpntc'pnngraPtlicallV:Jl,*` Ot cases described by Freundlich and Greening,**7 nw cent chewed pleural thickening alone. 41 per cent showed com bined pleural and narenchvmal manifesta tions,and only 11 per cent showwl parenchymal changes alone; the shaggy- heart sign was observed in 20 per cent A similar predominance of pleural over parenchyma] changes was reported by Anton:*30 of 40 patients with proved asbes tosis, only five had parenchymal changes in the lung bases, pleural plaques being the sole manifestation of the disease in the other 35.

t Medical News January IS. 1900 Experts cite paralysis of asbestos * a#: :x ::jcy **a*?.

POWift a DIRKCTORY POR MOOBRNIZATIO N --1 f S ) Qrlnmll C4 le, )M W tulM** V.

ChcM radiograms were screened bv a physician and repealed if they appeared tvchnicallv mivtiislaciory lor evaluation of pneumoconiosis bv ltd (Inlcrnuiion.d I alxMir (Irganizationl criteria Iherc.liter, thiee e\|vrieuced readers with at least ")i" re.nler qualifications for leading pneumoconiosis las established by Ihe American College of Kmliology) independently read (lie postcroanteriiw radiograms of all three groups for presence ami profusion of in egttlar opriciliex and presence and extent of pleural abnormalities (dillitse thickening, plaques, and ealcilication) They used the criteria of the 19110 revision of Ihe II.O classification for pneumoconiosis" which grades ihe profusion of opacities from absent (grade 0) lo few (grade It. to moderate (grade 21. ami numerous (grade 1).

** sA 1 BROWN, Todd & Heyburn RUCKER TOOO GEORGE OUOlCY EOWARO $ BONNiC joseph a hclm MARK B DAVtS wc MSh*.

PLAINTIFF'S EXHIBIT Experts cite paralysis of asbestos exposure control efforts One hears that considerable trouble is now taken to prevent the inhalation of asbestos dust, so therefore the disease is not likely to appear in the future " So proclaimed a British public health official in 1906 concerning the major health problem posed by the fledgling British asbestos industry Since that time, in the United States alone, 30 million tons of asbestos, "the wondrous mineral fiber with the strength of steel," has been nonetheless employed in many products.

After sectioning the tissue was stained on the grids with lead citrate {Reynold, 19G3) before being examined in the electron microscope.

Jones: Cardiovascular disease is our leading cause of death today.

by EUZABCTH N.

MOOUCTS APPLICATION LABORATORY B.T.GOODRICH CHEMICAL COMPANY Avon Lnk, Ohio Cuitoon Sorvico tof prt for Goon.

Nineteen Seventy-One Annual Report go CD CD CD cn CO 1897 1901 1916- 1U?

From this Cartier concluded that the factor enuring nbrtori* is not the same ns the factor thnt leads to pleural rnlrjfirntinn.

-ing nsbedodi is not the same ns the factor that leads to pleura!

/ l vox Fl < TRICHLOROETHYLENE.