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AR226-3192 DuPont-6541 TRADE SECRET Study Title H-24951: Biopersistence Screening 10-Dose Oral Gavage Study in Rats Laboratory Project ID: DuPont-6541 AUTHOR; Carol Finlay, B.A.

Perfluorooctanesulfoinate: PK During Pregnancy in Recovery + Analytical Protocol I i I I Li FINAL REPORT PROTOCOL 418-015 ORAL (GAVAGE) PHARMACOKINETIC RECOVERY IN RATS STUDY OF PFOS SPONSOR'S STUDY NUMBER: T-6295.14 FINAL REPORT DATE: 23 JULY 1999 PROTOCOL 418-015 ORAL (GAVAGE) PHARMACOKINETIC RECOVERY IN RATS STUDY OF PFOS SPONSOFRS STUDY NUMBER: T-6295.14 TABLE OF CONTENTS SUBJECT PAGE 1.

FinalReport Salmonell-aEscherichicaoli/N4ammalian-Microsome ReverseMutationAssay withPFOS PREPARED FOR: 3M CorporateToxicology COVANCE STUDY NUMBER: 20784-0-409 C 0 V A14-@EC@- THE DEVELOPMEW SERVW.ESCOMPAW FINAL REPORT SALMONELLA ESCHERICHIACOLI/MANUAALIAN-MICROSOME REVERSE MUTATION ASSAY WITH PFOS AUTHOR Michael S.Mecchi,MS PERFORMING LABORATORY Covance LaboratorieIsnc.

EFFECT OF SELECTED PERFLUORO-COMPOUNDS P-OXIDATION KendalBl.WallaceP,h.D.

BIOCONCENTRATION TEST SUBSTANCE Identity:N-ethylperfluorooctasnuelfonamidoethanolm;ay alsobe referredto as N-ETFOSE Alcoholor FM-3422. (1-OctanesulfonamideN,-ethyl1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-(2-hydroxyethyl)-, CAS # 1691-99-2) Remarks: Materialisan off-whitwea,xy solidofuncharacterizepdurity.

ACUTE TOXICITY TO FISH TEST SUBSTANCE Identity: Perfluorooctanesulfonyflluoridem;ay also be referredto as POSF, or FX-8. (1-Octanesulfonylfluoride, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluCoArSo-#, 30735-7).

Experiment No.: Conducted At: Dates Conducted: Conducted By: Reviewed By: Acute Oral Toxicity Screen with T-3494 in Albino Rats 0884AR0013 Safety Evaluation Laboratory Riker Laboratories, Inc.

coming HazletonInc.

WATER SOLUBILITY TEST SUBSTANCE Identity: PFeCr-f9l5u.or(o1o-cOtacnteasnuelsfuolnfaotnei;c macaidy,a1l,s1o,2b.e2,r3e,f3e,r4r,e4d,5t,o5,a6s,6P,7F,O7.S8,o8r,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder.

AR226-0191 OES `Compound-Specific, Quantitative Characterizationof Organic Fluorochemicals in Biological Matrices Kcisen) Hae;LisA.Clemens; Mark .

FY1-050-0 1378 At t achments Studies to Letter to C.

ems ttn pvr nin 00 FIRA9e 030M Studies and Other Information on Certain Perfluorooctane Sulfonate-Related Compounds [iwoasrosen|eippeorossass somemitostpt ene Acute Toxicity 1) Acute Oral Toxicity Screen with T-3493 in Albino Rats, Safety Evaluation Laboratory, Riker Laboratories, Inc., Project No. 0884AR0010, 3M Reference No.

Interim Report #2 Epidemiology, 220-3W-05 Medical Department 3M Company Paul.

Morea ore CoMmGTONKENTUGRY ore SE, aS pp TAFT, STETTINIUS & HOLLISTER LLP ven 425 WALNUT STREET, SUITE 1800 CINCINNATI, OHIO 45202-3957 assiiavnass Rbo(osiremo)r5t7A..a3B83oc0orme January 14, 2003 CERTIFIED MAIL NO. 7002 0860 0006 6119 4491 RETURN RECEIPT REQUESTED Ee ARRaG 2a6m-_o1u212r44 apmmCsae cow nes i ooore Pron i MR # 265382 Mary Dominiak United States Environmental Protection Agency Office of Pollution, Prevention and Toxics Chemical Control Division 1200 Pennsylvania Avenue, N.W.